en پژوهشي Research <span style="font-size:9pt"><span style="font-family:&quot;Minion Pro&quot;,&quot;serif&quot;"><b>Introduction</b>: Brucellosis is a highly prevalent disease affecting both humans and animals in Iran. Given the significant role of animal husbandry in Ilam province, it was important to conduct a spatiotemporal analysis of the disease in the region between 2014 and 2019.</span></span><br> <span style="font-size:9pt"><span style="font-family:&quot;Minion Pro&quot;,&quot;serif&quot;"><b>Materials & Methods</b><b><span style="font-size:11.0pt"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">: </span></span></b>This study is a descriptive-analytical study. Information about all individuals infected with Brucellosis was collected through a census method. Moran&#39;s I was employed to determine the clustering of the disease; Getis-Ord Gi analysis was utilised to identify hotspots; and the Cochran-Armitage test for trend was used for time analysis. Stata and GIS software were applied for data analysis.<span lang="FA" dir="RTL" style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"></span></span></span><br> <span style="font-size:9pt"><span style="font-family:&quot;Minion Pro&quot;,&quot;serif&quot;"><b>Results</b><b><span style="font-size:11.0pt"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">: &nbsp;</span></span></b>In total, 703 cases of Brucellosis were studied. The highest incidence rates were witnessed in Malekshahi (258.97 per 100,000 people) and Dehloran (256.93 per 100,000 people). The highest incidence of the disease by year was in 2014 (26.2 per 100,000 people), by age group was in people aged 41-60 years (213.87 per 100,000 people), and by sex was in men (133.72 per 100,000 people). According to the results of the Getis-Ord Gi analysis, Chardavol city in 2015 and Mehran city in 2016 were identified as hotspots at a 99% confidence level (p<0.01). Nevertheless, no clustering pattern was observed along the study years based on Moran&#39;s I results (p > 0.05 for all years). Further, the time trend of brucellosis from 2014 to 2019 was not significantly associated with p>0.05.</span></span><br> <span style="font-size:9pt"><span style="font-family:&quot;Minion Pro&quot;,&quot;serif&quot;"><b>Conclusion</b><b><span style="font-size:11.0pt"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">: &nbsp;</span></span></b>The study indicated that Malekshahi and Dehloran had the highest risk of brucellosis infection over the six-year period</span></span> Brucellosis, Ilam province, GIS, spatiotemporal analysis, Incidence Rate 66 76 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-901-1&slc_lang=en&sid=1 Faezeh Mohammadshahi fa12.mohamadshahi@gmail.com 10031947532846008542 10031947532846008542 No Department of Epidemiology, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran Parviz Shahmirzalou pshkhoei@gmail.com 10031947532846008543 10031947532846008543 No Department of Biostatistics, Khoy university of Medical Sciences, Khoy, Iran Ali Amarloei amarloei@yahoo.com 10031947532846008544 10031947532846008544 No Department of Environmental Health Engineering, School of Health, Ilam university of Medical, Ilam, Iran Ali Nazari dralinazari@yahoo.com 10031947532846008545 10031947532846008545 No Department of Infectious Diseases, School of Medicine, Ilam University, of Medical Science, Ilam, Iran Kourosh Sayehmiri Sayehmiri@razi.tums.ac.ir 10031947532846008546 10031947532846008546 No Department Biostatistics, faculty of health, Ilam university of Medical, Ilam, Iran Ali khorshidi Ali_482002@yahoo.com 10031947532846008547 10031947532846008547 Yes Department of Epidemiology, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran