en پژوهشي Research <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Introduction</b>: Since the onset of the COVID-19 pandemic in December 2019, various global measures have been adopted to curb its spread. Pharmacy staff are at the forefront of disseminating health information to the public. This study evaluates the knowledge, attitude, and anxiety levels regarding COVID-19 among pharmacy staff in Iran.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Materials & Methods</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: </span></span></b>This cross-sectional study was conducted between May 10, 2021, and September 20, 2021, involving pharmacy staff from the Ilam province in Western Iran. A semi-structured questionnaire, including sections on knowledge, attitude, and anxiety related to COVID-19, was used to collect data. Statistical analysis was performed using SPSS V.26, with a significance level of P<0.05.<span lang="FA" dir="RTL" style="font-family:"Times New Roman",serif"></span></span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Results</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: &nbsp;</span></span></b>Most of the pharmacy personnel (94.67%) knew a lot about the symptoms and (84.46%) how COVID-19 spreads. Also, 86.7% of the people who took part said they would be prepared to stay in quarantine if they showed signs of illness. 20.4% of the pharmacy personnel said that anxiety over COVID-19 got in the way of their everyday tasks.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Conclusion</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: &nbsp;</span></span></b>The findings show that pharmacy staff in Iran have adequate knowledge and a positive attitude toward COVID-19, with low levels of anxiety. Ongoing education and mental health support are essential to further improve their role in pandemic response.</span></span><br> &nbsp; Attitudes, Knowledge, Anxiety, COVID-19, Pharmacy Staff 52 63 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-970-1&slc_lang=en&sid=1 Hamid Heidarzadeh hheidarzadeh20@gmail.com 10031947532846008053 10031947532846008053 No Psychosocial Injuries Research Center, Department of Nursing, Faculty of Nursing and Midwifery, Ilam University of Medical Sciences, Ilam, Iran , Mohammad Reza Kafashian m_r_kaffashian@yahoo.com 10031947532846008054 000000015340690X No Psychosocial Injuries Research Center, Department of Clinical Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Kamyar Kazembeigi kamyar.kazembeigi1@gmail.com 10031947532846008055 0009-0006-8574-1300 No Non communicable disease research center, ilam university of medical sciences, ilam, iran Sara Mohammadnejad saranursing68@yahoo.com 10031947532846008056 10031947532846008056 No Department of Nursing, Faculty of Nursing and Midwifery, Ilam University of Medical Sciences, Ilam, Iran Seyed Salman Zakariaee salman.zakariaee@gmail.com 10031947532846008057 10031947532846008057 No Psychosocial Injuries Research Center, Department of Medical Physics, Faculty of Paramedical Sciences, Ilam University of Medical Sciences, Ilam, Iran Fakhredin Taghinezhad taghynejad@yahoo.com 10031947532846008058 10031947532846008058 No Department of Nursing, Faculty of Nursing and Midwifery, Ilam University of Medical Sciences, Ilam, Iran Younes Parvaz parvaz.younes21@gmail.com 10031947532846008059 10031947532846008059 Yes Psychosocial Injuries Research Center, Department of Clinical Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran