@article{ author = {Akhlaghi, Mahmoo}, title = {Anisocoria under general anesthesia with Propofol}, abstract ={Anisocoria during anesthesia is very rare, but may indicate life-threatening neurologic injuries and create tremendous condition. A 23-year-old male patient was anesthetized with fentanyl and propofol. Thirty minutes after inducing anesthesia, unilateral mydriasis was detected. The duration of surgery was shortened for prompt evaluation of the pupils. At the end of the operation neither vision problem nor obvious anisocoria was detected in the recovery room. Ophthalmological and neurological consultations revealed no pathological finding and the patient was discharged. Evaluation of the size of the patient;#39s pupils before operation would mitigate the fearful condition resulted from anisocoria.}, Keywords = {Anisocoria, General anesthesia, Propofol}, volume = {3}, Number = {4}, pages = {1-3}, publisher = {ilam university of medical sciences}, doi = {10.18869/acadpub.jbrms.3.4.1}, url = {http://jbrms.medilam.ac.ir/article-1-116-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-116-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2016} } @article{ author = {Bakhsha, Fozieh and Yousefi, Zahra and Aryaee, Mohammad and Jafari, Seyyed Yaquob and Derakhshanpoor, Firoozeh}, title = {Comparison effect of Lavender and Citrus aurantium aroma on anxiety in female students at Golestan University of Medical Sciences}, abstract ={Introduction: Test anxiety is a common phenomenon and the problematic concern of the educational system. Scented essentials like lavender (angustifolia) oil and Citrus aurantium (orange flower) oil have positive impact on people;#39s physical and mental condition and anxiety. This study was designed to compare and evaluate the effects of lavender essential oil aroma and Citrus aurantium essential oil aroma on test anxiety. Materials and methods: This double-blind clinical trial study was carried out on 80 female students from the Faculty of Paramedics Sciences, Gorgan city in 2013. Students were randomly and equally assigned to the two lavender or Citrus aurantium groups. All students smelled oil for a period of 60 seconds. To stay scents, some oil was rubbed on the candidates foreheads using an applicator. To evaluate the level of anxiety and stress before the intervention, Sarason Anxiety Test, and to measure the effect of essence after intervention, Visual Analogue Scale (VAS) questionnaire were used. Data were analyzed using SPSS16 software and the independent and paired T-tests. Results: The mean anxiety in students in lavender group dropped from (5.67±2.05) to (3.9± 1.82) and in Citrus aurantium group decreased from (5.25±2.06) to (3.97±2). This difference was statistically significant (P <0.001). The intervention had a significant effect on heart rate; however, had no effect on the blood pressure. Conclusion: According to the results, lavender and citrus aurantium scents had positive effects on students;#39 test anxiety and can be used as a cheap and good psychological care in treatment support systems to control and reduce anxiety with least side effects.}, Keywords = {Lavender, Anxiety, Citrus aurantium}, volume = {3}, Number = {4}, pages = {4-11}, publisher = {ilam university of medical sciences}, doi = {10.18869/acadpub.jbrms.3.4.4}, url = {http://jbrms.medilam.ac.ir/article-1-93-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-93-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2016} } @article{ author = {Azizi, Monireh and Bakhtiari, Mehrdad and FarahmandGhavi, Farhid and Zandi, Mojgan and Imani, Mohammad and Joghataei, Mohammad Taghi}, title = {Purity determining of cultured OECs from olfactory mucosa of rats\' pups}, abstract ={Introduction: Cell transplantation is one of the main strategies for spinal cord injury repair. As OECs of the olfactory mucosa can be obtained by simple biopsy in all individuals without affecting their smell sensation, OECs considered as a promising candidate for autologous transplantation in the nervous system injury, especially for spinal cord repair. Thereby in the current study OECs were cultured from olfactory mucosa of 7 days old rats' pups and their purity was examined by flow-cytometry after simultaneous double staining for p75 and GFAP markers. Materials and methods: 7 days old Wistar rats' pups were deeply anesthetized by ketamine / xylazine (60/6mg/Kg). Then the nasal cavity was opened sagittally and the olfactory mucosa was separated from posterior part of nasal septum and at last OECs were obtained from lamina properia of olfactory mucosa and were cultured. The cultured cells were simultaneously immunolabeled for p75 and GFAP markers and finally purity of cultured cells assessed by flow-cytometry. Results: cultured OECs demonstrated two different morphologies, a spindle shape Schwann-like and an astrocyte-like OECs with flat sheet-like morphology. In addition, simultaneous immunolabeling for p75 and GFAP markers of OECs exhibited   OECs were positive for both markers at the same time. The flow-cytometry results  displayed that 87.9±2.4% of cells were p75/ GFAP double positive cells,1.05±0.4 only p75 positive and 5.8±1.5% were single positive for GFAP. Conclusion: Purity of cultured OECs in our study is probably more than 87.9% by flow- owing to p75+/S100+ and GFAP+/S100+ olfactory ensheathing cells were not counted. Thus the culture procedure of this study seems to be a good protocol for OECs purifying and cell therapy in CNS damages.}, Keywords = {OECs, Cell therapy, Spinal cord injury, Flowcytometry}, volume = {3}, Number = {4}, pages = {12-21}, publisher = {ilam university of medical sciences}, doi = {10.18869/acadpub.jbrms.3.4.12}, url = {http://jbrms.medilam.ac.ir/article-1-178-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-178-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2016} } @article{ author = {GhanbariAfra, Leila and Zaheri, Azit}, title = {Comparison of depression in diabetic patients with and without foot wound}, abstract ={Introduction: Long-term complications of diabetes leads to physical and mental weakness and reduce their quality of life. One of the complications is the chronic wounds of extremities. Because of its outcome, patient’s adaptation can be reduced. The aim of this study was to compare depression between diabetic patients with and without foot wounds. Materials and methods: The comparative-descriptive study was performed on diabetic patients with and without foot wounds that admitted to the hospitals in Qom University of Medical Sciences in 2014. 100 patients with chronic wounds and 100 patients without the wounds was recruited by available sampling method for the study. We employed the “Demographic and clinical” and "Beck depression" questionnaires for gathering the data. The study data were analyzed by independent t and Chi-square tests using the SPSS (version 13) statistical software. Results: Mean and standard deviation of age in patient with and without chronic wound was 52.1±3.9 and 51.5±4.1 years, respectively. Depressive score of patient with and without chronic wound was also 25.6±9.5 and 8.7±2.1, respectively. Depression score of patient with underlying disease was higher than patients without underlying disease. The depression score rises with age. The depression scores were similar in both male and female gender. Conclusion: The depression in patient with chronic wounds was higher than patient without the wounds. Also, depression in patients with underlying disease and older age, rises.}, Keywords = {Chronic wound, Diabetes, Depression }, volume = {3}, Number = {4}, pages = {22-27}, publisher = {ilam university of medical sciences}, doi = {10.18869/acadpub.jbrms.3.4.22}, url = {http://jbrms.medilam.ac.ir/article-1-184-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-184-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2016} } @article{ author = {Beig-Mohammadi, Hossein and Masoudian, Nahid and Tabibi, Ali and Allameh, Abdolamir}, title = {Diagnostic value of a combined C-reactive protein and haptoglobin tests in new cases of upper tract urothelial carcinoma}, abstract ={Introduction: Serum C-reactive protein (CRP) is believed to be increased in metastatic urothelial cancer of the bladder. However, the changes depend on the stage and grade of the upper tract urothelial carcinoma (UTUC). This study aimed to compare low-range and high-range serum CRP and haptoglobin in new cases of UTUC. Materials and methods: Blood was collected from newly diagnosed patients with UTUC (n=43 patients; 39 male/4 female) and normal individuals (n=26; 24 male and 2 female) with no sign of infection or cancer. All the patients showed clinical symptoms of bladder cancer. Serum CRP and haptoglobin were estimated based on conventional methods. Results: Haematuria and polyuria were common symptoms in 65.12% of the patients suffering from UTUC. The serum level of HAPT in control and UTUC patients was 126±13 and 181±14.5 mg/dl respectively. No significant difference was observed in HAPT level in patients and controls. The HAPT was in the high-range level in 27% of controls and 30% of the patients. The average serum CRP level in patients and controls was 11.87±3.5 mg/l and 11.45±4.2 mg/l, respectively. Serum CRP was above 3.5 mg/l (>3.5 mg/l) in 46% of patients (20/43). The CRP level was significantly higher (P=0.023) in patients having CRP above 3.5 mg/l compared to respective controls. The UTUC patients were separated into two groups based on low-range (<3.5mg/l) and high-range CRP (>3.5 mg/l).Serum CRP was <3.5 mg/l in 69% of the controls, whereas 31% of controls had CRP >3.5 mg/l. However, 46% of UTUC patients had serum CRP > 3.5 mg/l and 54% of UTUC patients had serum CRP < 3.5 mg/l. Conclusion: Although there was no difference in haptoglobin levels in patients and controls, but serum CRP was significantly increased in patients and it was associated with clinical symptoms of UTUC, suggesting that serum CRP can be considered as a complementary test for detection of low-grade UTUC.}, Keywords = {Bladder cancer, Biomarkers, CRP, Haptoglobin, Low-grade }, volume = {3}, Number = {4}, pages = {28-33}, publisher = {ilam university of medical sciences}, doi = {10.18869/acadpub.jbrms.3.4.28}, url = {http://jbrms.medilam.ac.ir/article-1-210-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-210-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2016} } @article{ author = {Ramz, Kholoud and Abbasi, Naser and Hafeziahmadi, Mohammadreza and Azizi, Monireh and Hedayatpour, Azim and Abbaszadeh, Hojjatallah and Moayeri, Ardeshir}, title = {Effect of different concentrations of Aloe vera leave\'s extract on the healing process of rat\'s second degree burn}, abstract ={Introduction: The aim of this work was to evaluate the effects of four different concentrations of Aloe vera extract on healing of second degree burns in male Wistar rats. Materials and methods: By an experimental study 42 male Wistar rats were divided into 7 equal groups. The burn injury was made on the back of all rats, according to standard methods. The burned areas in the group1: were left without any intervention, group 2: were treated topically with eucerin, group 3: were treated with SSD and groups 4-7 were covered with 0.5%, 1%, 1.5%, 2% Aloe vera extract in eucerin (basal cream) twice a day, respectively. 21 days later the rats were sacrificed and samples of burnt skin tissue were collected for histological examinations. The parameters were evaluated to be considered for review included the number of hair follicles, sebaceous glands of angiogenesis, acute inflammation (severe infiltration of neutrophils) and the formation of epithelial layers. Results: Diagram of healing levels and reduction rats of wounds' sizes in 3th week indicated that the former was reduced more significantly in groups 3, 6 and 7 than in groups 1 (P<0.005) and 2 (P<0.01). Histological findings showed that burn healing was significantly better in groups 6 and 7 than the groups 1 and 2 at the day 21. Conclusion: It could be concluded that concentration of 1.5% and 2% of Aloe vera extract have an effective role in the treatment of burn wound healing.}, Keywords = { Aloe vera, SSD, Second degree burn}, volume = {3}, Number = {4}, pages = {34-39}, publisher = {ilam university of medical sciences}, doi = {10.18869/acadpub.jbrms.3.4.34}, url = {http://jbrms.medilam.ac.ir/article-1-215-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-215-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2016} } @article{ author = {Afzalpour, Mohammad Esmaiel and Yousefi, Mohammad Reza Yousefi and AbtahiEivari, Hossein and Ilbeigi, Saee}, title = {The comparison of continuous and intermittent training impact on glucose-4 transporter protein level and insulin sensitivity in diabetic rats}, abstract ={Introduction: Diabetes mellitus (DM) is now seen as a worldwide epidemic disease with high prevalence. Exercise training (ET) is known to promote beneficial changes in diabetic patients. The aim of this study was to compare the impact of continuous and intermittent aerobic training on glucose-4 transporter protein (GLUT-4) levels and insulin sensitivity in diabetic rats. Materials and methods: This research was an experimental and interventional study. A number of 60 male rats weighing 180 to 310 grams and 13 weeks old were divided into six groups: healthy control, healthy continuous, healthy intermittent, diabetic control, diabetic continuous, and diabetic intermittent groups. The exercise protocol in both continuous and intermittent groups was aerobic training for six weeks which was conducted considering overload principle. The data were analyzed using one-way analysis of variance test in P< 0.05 level. Results: The results showed that despite the significant difference between insulin resistance and GLUT4 level among diabetic rats in different groups compared to control group, there was no significant difference between the impact of continuous and intermittent training on these indices (P=1.00). Conclusion: Through increasing the GLUT4 protein content, the continuous and intermittent training improved insulin resistance.}, Keywords = {GLUT4, Insulin sensitivity, Continuous training, Intermittent training}, volume = {3}, Number = {4}, pages = {40-48}, publisher = {ilam university of medical sciences}, doi = {10.18869/acadpub.jbrms.3.4.40}, url = {http://jbrms.medilam.ac.ir/article-1-232-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-232-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2016} } @article{ author = {Nafisi, Saeed and Rezazadeh, Leila and Hosseini, Ehsan and Shamsi, Morteza and BahramiMousavi, Anwar and Bahrami, Ali Mohamm}, title = {Citrullus colocynthis fruit extract as an anti-depressant in mice}, abstract ={Introduction: Depression has multifactorial characters including brain-behavioral disorders, alteration in cognitive psychomotor and emotional process. Millions of people are worldwide suffering from this illness. This disease happens in all ages of men and women. This research tries to introduce a traditional medication in comparison with common chemical anti-depressant drugs. This experiment was designed to evaluate probably the antidepressant effect of Citrullus colocynthis fruit extraction. Materials and methods: Thirty-two male mice (Balb/c) was randomly divided to four groups (n=8 each). Animals adapted and treated to diazepam, imipramine, aqueous and hydro alcoholic extract of Citrullus colocynthis fruit. All administrations were done via intraperitoneal 0.2ml/animal. Plant material after grinding was extracted with ethanol and evaporated under reduced pressure. Tail suspension test was carried out to assay the antidepressant effect of plant extraction in animals. The test was carried on before, and as well as 30, 60 and 120 minutes after injections. Results: Our data indicated that after intraperitoneal administration of aqueous and ethanol extract, immobility duration exhibits statistically significant increase compared to agitation phase in all times after injection(P<0.05). Ethanol extract reduced statistically agitation time in 30, 60 and 120 min after injection compared to imipramine. Both aqueous and ethanol extract elevated immobility in minute 60(P<0.5). Conclusion: The present study suggested that Citrullus colocynthis extract could possess potential antidepressant and sedative effects which would be of therapeutic interest for using in the treatment of patients with depressive disorders. We suggest more research in this regard.}, Keywords = {Anti-depressant, Citrullus colocynthis, Herb, Mice}, volume = {3}, Number = {4}, pages = {49-55}, publisher = {ilam university of medical sciences}, doi = {10.18869/acadpub.jbrms.3.4.49}, url = {http://jbrms.medilam.ac.ir/article-1-228-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-228-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2016} }