@article{ author = {Barzegari, Amir Abbas and Hashemzaei, Masood and Alihemmati, Ali-Reza and Soltani, Soroush and Naseri, Behrouz}, title = {Effects of Lactobacillus rhamnosus (ATCC 7469) ointment on second-degree burn wound in Wistar rat}, abstract ={Introduction: Burn is among the traumas that impose great physical and psychological damages to the injured people. Scientists still are looking for new treatments and methods for burn management that lack the defects of previous ones. Recently, the potential of probiotic bacteria for the treatment of skin disease and problems has been investigated. Considering that the effects of probiotics are strain-dependent, the aim of current study was to evaluate the effects of Lactobacillus rhamnosus (ATCC 7469) on the process of burn wound healing. Materials and methods: After induction of second-degree burn wounds on the back of rats, they were randomly divided into experimental, vehicle control, and negative control groups. The experimental groups received a bacterial ointment for 1, 3, 7, and 14 days. The vehicle control groups received Eucerin for durations like the experimental groups. The negative control groups received no treatment in the same days. The evaluation of wound healing was conducted macroscopically by computing of the healing percent and microscopically by Hematoxylin and Eosin staining of the tissue samples of the wound area on different days. Results: The wound healing percent in the experimental group, compared with control groups, significantly increased, until the day 7 of the experiments. Moreover, the microscopic results indicate that the bacteria may have some anti-inflammatory effects. Also, the bacteria increased the rate of fibroblastic migration and re-epithelialization in the wound area. Conclusion: Overall, L. rhamnosus (ATCC 7469) when used topically on the burn wounds may have some positive effects on the process of burn wound healing.}, Keywords = {Lactobacillus rhamnosus, Probiotics, Burns, Wound healing, Rats}, volume = {5}, Number = {1}, pages = {1-9}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.1.1}, url = {http://jbrms.medilam.ac.ir/article-1-348-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-348-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Modaresi, Mehrdad and AlasvandZarasvand, Mahnaz and Madani, Mahboobeh}, title = {The effects of hydro-alcoholic extract of Artemisia dracunculus L. (Tarragon) on hematological parameters in mice}, abstract ={Introduction: Artemisia dracunculus L. (Tarragon) is one of the plants that uses as meal and remedy for a long time, and possesses many medicinal properties. In traditional medicine also has mentioned to its beneficial properties. A number of researches through in vitro and in vivo studies showed the pharmacological properties of this plant. This study was done for determining the effect of hydro-alcoholic extract of A. Dracunculus L. on some hematological parameters among mice. Materials and methods: In this study, 40 male mice were divided into five groups: a control, a placebo, and three treatment groups that were injected with 50, 100, and 200 mg/kg doses of hydro-alcoholic extract of tarragon every other day for 20 days. At the end of injections, the levels of WBC, RBC, lymphocytes, monocytes, and neutrophils were measured. Statistical analysis was done using SPSS software and analysis of variance (ANOVA) test. Results: The obtained results showed that there was no significant difference in amounts of WBC, RBC, and monocytes in the treatment groups in comparison with the control group. Lymphocytes showed significant decrease in groups of 100 and 200 mg/kg doses than the control group. The level of neutrophils showed significant increase in two treatment groups (100 and 200 mg/kg) than the control group. Conclusion: It can be concluded that the hydro-alcoholic extract of tarragon stimulates the production of neutrophils in this study which can be used as an immunostimulating agent.}, Keywords = {Artemisia dracunculus L., Blood parameters, Hydroalcoholic, Mice}, volume = {5}, Number = {1}, pages = {10-14}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.1.10}, url = {http://jbrms.medilam.ac.ir/article-1-298-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-298-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Daliri, Salman and Asadollahi, Khairollah and Musavi, Mir Hadi and Karimi, Arezou and Khademi, Gholam Ali and Azizi, Monire and Abangah, Ghob}, title = {The relationship between neonatal factors and involving with glucose-6-phosphate dehydrogenase deficiency (G6PD) and patients\' outcome in Fars Province}, abstract ={Introduction: Glucose-6-phosphate dehydrogenase deficiency (G6PD) or fauvism is the most common enzyme deficiency in human, so that 400 million people are living with this disease worldwide. This study aimed to investigate the role of some neonatal factors among newborns suffering from G6PD deficiency and neonatal outcomes associated with this disease. Materials and methods: In this study, two methods including case-control and retrospective cohort regarding some neonatal factors associated with G6PD deficiency were used. These methods were performed on 142 children with this kind of deficiency and 142 healthy infants in the city of Marvdasht during 2013- 2014. The analysis of data was based on chi-square tests, t-test, logistic regression, descriptive statistics and estimation of odds ratios or relative risks via SPSS16 software. Results: Totally 284 newborns including 132 (46.6%)/ 152 (53.4%) boys/girls and mean weight on birth of 3163 ± 471 (gr) were analyzed. Comparison of case and control samples did not show any significant differences between sex and involving with G6PD deficiency but the chance of having a baby with this defect in pregnancy intervals between 6 to 8 years was increased (95% CI: 1- 4.4, OR: 2). Relative risk of jaundice in infected and healthy infants was estimated as 3.73, which demonstrated a statistically significant association (95% CI: 1.33- 10.4). The frequency of low birth weight, birth order and type of delivery was associated with the disease, but their differences were insignificant compared to the healthy group. Conclusion: The results of this study showed that the number of hospitalization is increased due to jaundice in infants with G6PD. There is also an insignificant relation between low birth weight, rank of birth and type of delivery. Thus, it is recommended that other consequences of this deficiency need to be revealed by screening other populations with more samples.}, Keywords = {Iran, Fars, Favism, Neonate, Newborn, G6PD}, volume = {5}, Number = {1}, pages = {15-21}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.1.15}, url = {http://jbrms.medilam.ac.ir/article-1-289-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-289-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Babaei, Arash and Jafari, Arash and Asadpour, Mohammad and Shamsi, Mortez}, title = {Cucurbita maxima (Pumpkin) seeds: Scolicidal activity and preventive efficacy of its extract on experimental hydatidosis in mice}, abstract ={Introduction: Hydatid Disease (HD), a helminth infection with various clinical complications is a serious economic and public health concern around the world. Nowadays, different agents have been broadly applied as scolicids; these agents have several side effects on patients. Therefore, the aims of this experimental study were to evaluate the scolicidal activity of Cucurbita maxima seeds methanolic extract (ME) against protoscolices of hydatid cyst in-vitro. Also, an in vivo assay was designed to prove the preventive effects of the extract. Materials and methods: For this work, Two different concentrations (25 and 50 mg/ml) of the C. maxima seeds ME were used in various exposure times (10, 20, 30, 40, 50, and 60 min). Additionally, thirty mice were infected intraperitoneally by injection of 1000 viable protoscolices and were divided into three groups with ten mice in each Group I (treated by Albendazole), group II (received 50 mg/ml of C. maxima seeds ME) and group III (untreated controls). Results: Overall, C. maxima seeds ME exhibited significant scolicidal effects in compared with control group (P<0.05). At a concentration of 50 mg/ml, the mortality percentage increased to 84.7%, 96.1% and 100% after 40, 50 and 60 minutes, respectively. Also, the obtain data in necropsy demonstrated that C. maxima seeds ME have an inhibitory effect on the hydatid cyst development. No hydatid cyst formation observed in mice treated with C. maxima seeds ME (50 mg/ml) versus control group which hydatid cyst occurred in 6 (from 10) mice. Conclusion: The current investigation indicated that applying C. maxima seeds ME could be considered as a potential scolicidal agent due to being economical, safer and non-toxic compared to the reference chemical drugs. However, further studies on probably active compounds and also to the determination of its mode of action on parasites are required.}, Keywords = {Hydatid disease, Cucurbita maxima methanolic extracts, Scolicidal, Preventive assay}, volume = {5}, Number = {1}, pages = {22-28}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.1.22}, url = {http://jbrms.medilam.ac.ir/article-1-326-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-326-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {NayebiFar, Shila and TaheriChadorneshin, Hossei}, title = {Aerobic exercise training reduces inflammatory markers involved in atherosclerosis}, abstract ={Introduction: Adipose tissue and inflammatory factors play important role in occurrence of atherosclerosis in overweight women. The present study aimed to investigate the effect of 8 weeks of aerobic exercise training on risk factors involved in atherosclerosis in overweight women. Materials and methods: For this, fourteen overweight women (mean ± standard deviation: body mass index 28.49 ± 3.28 k/m2 and body fat  35.01 ± 3.68%) conducted aerobic exercise training for 8 weeks (at intensity correspond with 65 to 80 % reserved heart rate). Before and after aerobic exercise training, fasting blood samples were taken and anthropometrics characteristics were measured. The data were analyzed using Paired sample t-test (P<0.05). Results: Aerobic exercise training significantly increased maximal oxygen consumption in overweight women (P=0.001). In contrast, aerobic exercise training result in significant reduction in intracellular adhesion molecule 1 levels (P=0.013) and C-reactive protein (P=0.001). In addition, anthropometric measurements of body fat percentage (P=0.006), waist to hip ratio (P=0.01), and body mass index (P=0.001) showed a significant reduction, too. However, no significant change observed in platelet (P=0.127), high density lipoprotein (P=0.107), low density lipoprotein (P=0.095) and cholesterol (P=0.391) levels. Conclusion: Reduction in body fat following aerobic exercise training in overweight women is corresponding with a reduction in inflammatory markers involved in atherosclerosis.}, Keywords = {Aerobic exercise training, Intracellular Adhesion Molecule1, C-reactive protein, Body fat percent}, volume = {5}, Number = {1}, pages = {29-37}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.1.29}, url = {http://jbrms.medilam.ac.ir/article-1-347-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-347-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Yari, Reza and Khodadadi, Iraj and Aliyari, Farshid and Saremi, Zahr}, title = {Influences of combining nano zinc, honey and Aloe vera to accelerate healing the wounds caused by third–degree burn in male balb/c mice}, abstract ={Introduction: Burns are one of the most common household and industrial injuries. There are evidences which demonstrate the therapeutic properties of honey and Aloe vera. We evaluated the topical influences of this material and nano zinc combination on healing the wounds caused by third-degree burns. Materials and methods: 32 balb/c mice divided into a control group (without treatment), group 1 (treated with Aloe vera and nano zinc), group 2 (treated with Aloe vera, honey and nanoz inc) and group 3 (treated with honey and nano zinc). The third-degree burn was created on the back of balb/c mice with general anesthesia observing sterile conditions. Local treatment of burn was conducted once a week during 6 weeks and after the end of treatment, were anesthetized by ether and then killed. After fixation, the practical steps of general histology technique were performed on it. The samples stained with hematoxylin–eosin and they observed with a microscope. Results: We found full tightening of the burn wound and less scar in the group treated with nano zinc and honey compared to control group and other groups. In histological studies, a significant increase was found in the overall thickness of the skin, keratinocyte layer, the epidermis and hypodermis, number and diameter of the hair follicles in a third group versus other groups. Conclusion: The results showed the organic honey and nano zinc combination accelerate the healing process of burn wound in male balb/c mice. While adding Aloe vera to this composition doesn't have an effect on wound healing.    }, Keywords = {Nano zinc, Honey, Aloe vera, balb/c mouse, Burns}, volume = {5}, Number = {1}, pages = {38-46}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.1.38}, url = {http://jbrms.medilam.ac.ir/article-1-314-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-314-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Niroomand, Hassan and Binaafar, Sima and Nasiri, Moein and Mansournia, Nasrin and BagheriBehzad, Atoos}, title = {Sperm abnormalities: Adverse effects of thyroid dysfunction}, abstract ={Introduction: Despite the importance of thyroid hormones in reproduction, there are only a few studies that focus on male infertility. The objective of this study was to evaluate semen parameters in patients with hypothyroidism or hyperthyroidism. Materials and methods: Totally, 28 patients with thyroid disorders were evaluated for the semen parameters. Serum TSH and T4 concentrations were measured by ELISA. Complete semen analyses were performed based on WHO. Results: Pathozoospermia was seen in 32.14% of our patients. Two hyperthyroid patients and seven hypothyroid patients suffered sperm defects. None of pathozoospermia patients showed an alone sperm defects. Sperm multiple anomalies were our main findings. Conclusion: It seems that sperm characterizes strongly were affected. Although, we have a limited sample size, but sperm multiple abnormalities made our interest findings.}, Keywords = {Infertility, Semen, Sperm abnormality, Hypothyroidism, Hyperthyroidism}, volume = {5}, Number = {1}, pages = {47-50}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.1.47}, url = {http://jbrms.medilam.ac.ir/article-1-354-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-354-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Rouhi, Samaneh and Rooshani, Daem and Shakib, Pegah and AhangarKani, Fatemeh and Ramazanzadeh, Rashi}, title = {A 10-year survey on prevalence and occurrence rate of multi-drug resistant Mycobacterium tuberculosis in Latin American and Mediterranean Families: A Systematic review and meta-analysis}, abstract ={Introduction: Latin American and Mediterranean (LAM) is a family of Mycobacterium tuberculosis (M. tuberculosis). Drug resistant in M. tuberculosis LAM family is a major problem in the world population. Our objective of this study was to determine the prevalence of M. tuberculosis LAM family with multi-drug resistant (MDR) in the worldwide by a meta-analysis and systematic review. Materials and methods: Data sources of this study were 68 original articles (2001-2012) which were published in different databases. Research articles with full text in English were selected. Review articles, congress abstracts, studies that were reported in languages other than English and also studies that were not available for us in abstract or full text were excluded. Data that were obtained from prevalence and occurrence rate of MDR M. tuberculosis LAM family were analyzed using meta-analysis random effects models with software package Meta R, Version 2.13 (P < 0.10). Results: During 10 years, lowest rate of prevalence was observed in 2010 and 2006 (95% CI: 5.91%-6.95%) and highest prevalence rate was in 2006 (95% CI: 17.48%- 24.05%). prevalence of MDR- M. tuberculosis analysis showed positive MDR between them (95% CI: 10.30%-11.23%). Prevalence for negative MDR was 9.22% (95% CI: 8.3%- 10.2%). Conclusion: Our study showed that M. tuberculosis LAM family is prevalent in Europian countries. LAM sub lineage was a major focus of studies that carried out in different countries. The proper technique for prevention of transmission of M. tuberculosis is necessary.}, Keywords = {Prevalence, Mycobacterium tuberculosis, Latin American and Mediterranean Family, Multi-Drug Resistant}, volume = {5}, Number = {1}, pages = {51-61}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.1.51}, url = {http://jbrms.medilam.ac.ir/article-1-313-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-313-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} }