@article{ author = {Shamshirgaran, Marzieh and Maleki, Asma and Askari, Parvin and Yousefi, Masoud and MalakiMoghadam, Hakimeh and Aramjoo, Hamed and Zare_Bidaki, Maji}, title = {Antibacterial effects of the aqueous extract of Lycopersicon esculentum mill native in South Khorasan of Iran against four species associated with gastrointestinal infections}, abstract ={Introduction: Raising antibiotic resistance has led the human community to more frequent application of herbal medicines. The tomato fruit, scientifically called Lycopersicon esculentum mill, is an important source of vitamins, minerals, and antioxidants, all with beneficial effects on human health. The present study aimed to evaluate the antibacterial effects of tomato aqueous extract on four species of common bacteria associated with gastrointestinal infections. Materials and methods: After preparing the aqueous extract of native tomato, its minimum inhibitory concentration (MIC) was determined against Staphylococcus aureus (S. aureus) (TCC116538), Klebsiella pneumonia (K. pneumonia) (ATCC700603), Shigella flexneri (S. flexneri) (ATCC12022), and Proteus vulgaris (ATCC6380) species using micro dilution broth method based on the Clinical and Laboratory Standards Institute guidelines. Each of the experiments was repeated three times. The results were subdivided into normal and abnormal variables by one-sample Kolmogorov-Smirnov test. One-way Analysis of Variance (ANOVA) was used for examining normal variables. Results: The results of this study showed that the most significant effect of the tomato extract is on S. aureus. The MIC of tomato extract for S. aureus was 31.25 mg/ml, while for Proteus vulgaris, K. pneumoniae, and S. flexneri was 62.5 mg/ml. The mean MIC of the extract was significantly different between the studied bacteria (P < 0.05). The LSD post hoc test showed that the MIC for S. aureus (0.0599 ± 0.001) was significantly higher than that of Shigella flexinari (S. flexneri) (0.351 ± 0.009) (P < 0.001), K. pneumoniae (0.469 ± 0.062) (P = 0.001), and Proteus vulgaris (0.492 ± 0.005) (P = 0.003). Moreover, the MIC for S. flexneri was significantly lower than that of K. pneumoniae (P = 0.002) and Proteus vulgaris (P = 0.001). The mean MIC values for K. pneumoniae and Proteus vulgaris (P = 0.394) were not significantly different. Conclusion: The current study revealed a significant antibacterial effect of tomato extract against different bacterial species. Therefore, the extract can be used as an antiseptic agent in pharmaceutical and food industries.}, Keywords = {Lycopersicon esculentum mill, Antibacterial effect, Micro dilution broth}, volume = {7}, Number = {3}, pages = {1-6}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-502-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-502-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2020} } @article{ author = {Nazari, Somayeh and TaheriChadorneshin, Hossein and Marefati, Hamid and Abtahi‑Eivary, Seyed‑Hosei}, title = {The effect of rope jump training on serum levels of lipocalin-2, anthropometric parameters, and aerobic power in obese adolescent boys}, abstract ={Introduction: Lipocalin-2 derived from adipose tissue is associated with insulin resistance, systemic inflammation, and cardiovascular disease in obese people. The current study aimed to investigate the effect of rope jump exercise training on serum lipocalin-2 levels, anthropometric parameters, and maximal oxygen uptake (VO2max) in obese adolescent boys. Materials and methods: Twenty obese adolescent boys participated voluntarily in the study and were equally assigned to control and rope jump groups. Rope jump exercise protocol was practiced in 8 weeks, 3 days per week. Blood samples were taken before and after the program. The VO2max of each participant was estimated using Cooper's 12-minute run test. Serum lipocalin-2 levels were measured using a commercial ELISA kit. Results: Within-group comparisons revealed that rope jump exercise training resulted in a significant reduction in weight (P = 0.005), BMI (P = 0.002), abdominal circumference (P = 0.001), body fat percentage (P = 0.001), and serum levels of lipocalin-2 (P = 0.002). In contrast, lean body mass (LBM) (P = 0.047) and VO2max (P = 0.007) increased significantly in the rope jump group. After the intervention, abdominal circumference (P = 0.001), body fat percentage (P = 0.001), weight (P = 0.001), and BMI (P = 0.001) were significantly lower in the rope jump group than in the control group. VO2max in the rope jump group was significantly higher than in the control group at the end of the exercise training protocol (P = 0.001). However, no significant differences were found between the groups concerning lipocalin-2 level (P = 0.105), waist-to-hip ratio (P = 0.461), and LBM (P = 0.053) at the end of the protocol. Conclusion: While rope jump exercise training enhanced anthropometric parameters and aerobic power in obese adolescents, it failed to significantly alter the serum lipocalin-2 level, as an inflammatory marker.}, Keywords = {Rope jump training, Lipocalin-2, Adolescents, Obesity}, volume = {7}, Number = {3}, pages = {7-18}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-459-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-459-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2020} } @article{ author = {Aria, Behzad and Salegi-abarghui, Amin and Lotfi, Mohammad Hasan and Mirzaei, Masou}, title = {Effect of exercise, body mass index, and waist to hip ratio on female fertility}, abstract ={Introduction: Infertility is a common problem among many couples. Exercise and weight loss seem to be among the effective factors on fertility. Therefore, the aim of this study was to investigate the effect of exercise, body mass index (BMI), and waist to hip ratio (WHR) with female fertility. Materials and methods: This cross-sectional study was conducted on the data collected from Shahedieh Cohort. In this research, 1445 women (717 infertile and 728 fertile) were selected using the multi-stage cluster sampling method. Data on exercise, BMI, and WHR were compared between the infertile and fertile female groups. Independent t-test and logistic regression were used to analyze the data. Results: A significant difference was found between the two study groups regarding BMI, WHR, and exercise levels (P <0.05). The results of regression test showed that pysical activity had a significant effect on fertility (P <0.01), but BMI and WHR had no significant effect on it (P = 0.38 and 0.35, respectively). Conclusion: Based on the findings, it seems that exercise, regardless of changes in BMI and WHR, can increase fertility.}, Keywords = {Exercise, Body mass index, Waist to hip ratio, Fertility, Women}, volume = {7}, Number = {3}, pages = {19-25}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-531-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-531-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2020} } @article{ author = {Kalani, Navid and Shahrbanian, Shahnaz and Riahi, Zahr}, title = {Effects of resistance training with theraband on pain and quality of life in patients with knee osteoarthritis}, abstract ={Introduction: Joint pain, especially pain in the knee joint, is one of the most important problems that people with osteoarthritis report.The aim of this study was to determine the effects of resistance training with theraband on pain and quality of life in patients with knee osteoarthritis. Materials and methods: Twenty five patients with knee osteoarthritis with age range of 38 to 65 years’ old who had no history of any exercise during the past six months, and had no chronic conditions affecting on study outcomes were selected as study sample and randomly divided into two groups including experimental (n = 13) and control (n = 12) groups. The experimental group performed 8 weeks of resistance training, and the control group did not receive any intervention. SF-36 and Numeric pain rating scale were used to assess quality of life and pain, respectively. Finally, data were analyzed using SPSS software and independent t-test analysis. The level of significance was considered to be equal or less than 0.05. Results: The results of this study showed that after using intervention in the experimental group pain had a significant decrease compared to the control group (p=0.012). Also, eight weeks of intervention indicated a significant difference in the quality of life of patients with knee osteoarthritis between the control and experimental groups as it was increased in the experimental group compared to the control group(p=0.001). Conclusion: The findings of this study indicated that resistance training with theraband can reduce pain and enhance quality of life in patients with knee osteoarthritis.}, Keywords = {Resistance Training, Knee osteoarthritis, Pain, Quality of Life, Theraband}, volume = {7}, Number = {3}, pages = {26-35}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-525-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-525-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2020} } @article{ author = {Shanbehzadeh, Mostafa and Basati, Gholam and Kazemi-arpanahi, Hadi}, title = {Determining a suitable technical architecture for COVID-19 information exchange infrastructure: A case for Iran}, abstract ={Introduction: Improving the quality, safety and effectiveness of health care services is the most important advantages of using the Public Health Information Exchange (PHIE) infrastructure. This infrastructure has three centralized, decentralized, and hybrid architectures. This study sought to identify the most appropriate technical architecture for the coronavirus disease (COVID-19) Information Exchange (CoVIE) based expert panels. Materials and methods: In order to identify the desired CoVIE technical architecture, a qualitative approach was used and a number of meetings were held with experts in Health Information Technology and Management (HITM) and Health Informatics fields working at Iran, Tehran and Shahid Beheshti University of Medical Sciences (IUMS, TUMS and SBUMS). Basic concepts, including the type of technical architecture and exchange context, were categorized and discussed in terms of themes, sub-themes, and codes. Finally, the results were evaluated using content analysis and descriptive statistics. Results: The universities of Iran and Tehran had chosen hybrid model in national context and Shahid Beheshti University selected regional centralized model as the optimal technical architecture for CoVIE.  Conclusion: Hybrid model with implementation at national context was selected for CoVIE in Iranian health system. Implementation of this architecture improves the effective management of information exchange in the context of CoVIE.}, Keywords = {COVID-19, Public Health Information Exchange (PHIE), Technical architecture, Hybrid model, Centralized model, Decentralized model}, volume = {7}, Number = {3}, pages = {36-46}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-511-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-511-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2020} } @article{ author = {Kyriazi, Vasiliki}, title = {The role of von Willebrand factor alterations in thyroid disorders}, abstract ={Thyroid hormones are mediators of various metabolic processes including haemostasis. Von Willebrand is a multimeric glycoprotein with a major role in blood coagulation, participating in platelet adhesion to subendothelial collagen. It is also a carrier protein and stabilizer of circulating factor VIII and a marker of endothelial activation. This review aims to summarize the available data with regards to changes of von Willebrand factor in thyroid disorders, possible pathophysiological mechanisms, and their significance in clinical practice. PUBMED database was used for literature search in the English language over the last 20 years. Von Willebrand factor and coagulation factor VIII seem to have a key role in the pathogenesis of bleeding and thrombosis in thyroid disorders. Clinical hypothyroidism is associated with acquired von Willebrand syndrome due to the reduction of von Willebrand factor synthesis and release into the circulation. The implication of the von Willebrand factor in the prothrombotic environment induced by subclinical hypothyroidism is not clear. Hyperthyroidism increases the thromboembolic risk by increasing the levels of procoagulant agents including the von Willebrand factor. However, the available studies are highly heterogeneous in design and most of them investigate the laboratory changes of von Willebrand factor in patients with thyroid disease without any clinical implication. Patients with haemostatic disorders should be screened for underlying thyroid disease. Von Willebrand factor changes are corrected by restoring thyroid function. However, the implementation of early treatment in subclinical thyroid disorders has not been established.}, Keywords = {Haemorrhage, Hyperthyroidism, Hypothyroidism, Thrombosis, von Willebrand factor}, volume = {7}, Number = {3}, pages = {47-61}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-507-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-507-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2020} } @article{ author = {Ghodsi, Alireza and Mirimoghaddam, Mohammad Mobin and Sarabi, Mehrdad and DehghanTarazjani, Amirreza and Omranzadeh, Alireza and MahdaviRashed, Masoud and Rahimi, Hamid Rez}, title = {Neutrophil-to-lymphocyte ratio as a novel and valuable marker for assessing disease severity in Ulcerative colitis, Multiple sclerosis, and Kawasaki disease: A review}, abstract ={Ulcerative colitis (UC), multiple sclerosis (MS), and Kawasaki disease (KD) are three autoimmune diseases that involve the colon mucosa, myelin of the central nervous system neurons, and vascular epithelium. All these diseases need invasive, expensive, and complex modalities or criteria in order to monitor the disease severity. Recently, the neutrophil-to-lymphocyte ratio (NLR) has been proposed as a valuable, cheap, and easy marker of systemic inflammation. As all the above-mentioned diseases involve neutrophils and lymphocytes as the two major cell lines, it may be applicable to assess their severity according to the NLR. Here, we review the available literature with this regard.}, Keywords = {Neutrophil to lymphocyte ratio, Ulcerative colitis, Multiple sclerosis, Kawasaki disease}, volume = {7}, Number = {3}, pages = {62-70}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-527-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-527-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2020} } @article{ author = {Ghodsi, Alireza and Dadpour, Bita and ShokriToroghi, Zahr}, title = {Aluminum phosphide poisoning, an unusual presentation}, abstract ={Aluminum phosphide (ALP) is a very toxic compound commercially accessible as "rice tablet" in some markets in Iran. Although this toxin is used as a pesticide to protect grains from pests, it may be used for committing suicide. The poisoned patient experiences gastrointestinal problems as the first clinical manifestations in case of oral use, then develops acid-base disturbance, shock, and death in many cases. Intoxication with ALP can also affect the patient's hemodynamic status and cause electrocardiograph alterations, dysrhythmias, and even myocardial necrosis. In the current study, we introduce a young man who consumed an ALP tablet in a suicidal attempt and developed myocardial infarction even before metabolic acidosis and hypotension.}, Keywords = {Aluminum phosphide, Myocardial infarction, Phosphine, Poisoning}, volume = {7}, Number = {3}, pages = {71-74}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-529-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-529-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2020} }