@article{ author = {Tabrizi, Jafar Sadegh and Partovi, Yeganeh and Bahrami, Amir and Asghari, Mohamm}, title = {Quality assessment of care provided to patients with type 2 diabetes based on Clinical Practice Guidelines}, abstract ={Introduction: Diabetes is one of the usual medical problems that had an important negative effect on patient’s health. Researches demonstrate that there is a wide gap between recommended medical actions and received care by patients with diabetes. The aim of study was to assess the quality of care provided to patients with type 2 diabetes. Materials and methods: A cross-sectional study was carried out among 180 people with type 2 diabetes in diabetic’s clinics using convenience sampling method in Tabriz, Iran in 2011. Using a questionnaire we assessed the reported adherence to minimum recommended annual care for 23 processes indicators based on Iranian Diabetes Guidelines.  Results: The proportions of the participants who received recommended annual care for all three top clinical and all six top lifestyle indicators were 82.26% and 43.96%, respectively. For lifestyle and management indicators, reported adherence rates to guidelines were low (38.9% for medication review, 67.7% for self-management evaluation, 55% for physical activity review, and 58.3% for nutrition consultation). From the participants' perspective, most of the participants (87%) had well-controlled diabetes. Conclusion: A substantial proportion of people with type 2 diabetes indicated receiving suboptimal care and there is a notable gap between their expectations and what they have actually received in most aspects of the provided care.}, Keywords = {Type 2 diabetes, Quality assessment, Clinical practice guideline }, volume = {4}, Number = {1}, pages = {1-7}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.18869/acadpub.jbrms.4.1.1}, url = {http://jbrms.medilam.ac.ir/article-1-105-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-105-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {AzamianJazi, Akbar and Abdi, Hadi and HaffeziAhmadi, Mohammad Reza and Cheraghi, Jav}, title = {Effect of endurance exercise training on morphological changes in rat heart tissue following experimental myocardial infarction}, abstract ={Introduction: Cardiac remodeling after myocardial infarction, is associated with progressive ventricular dysfunction and cardiovascular death. The purpose of this study was to examine the effect of endurance exercise training on morphological changes in rat heart tissue following experimental myocardial infarction. Materials and methods: Rats used in this experiment (8-10 weeks old, 235 ± 5 g body weight) after homogenization according to body weight, were randomly divided to three groups: Healthy (Sham), control (Sedentary) and endurance training groups. Myocardial infarction was induced by subcutaneous injection of isoprenaline (150 mg/kg) in two consecutive days with an interval of 24 hours. Endurance training initiated 2 days after infarction and continued for 4 weeks. In order to assess the necrosis lesion and fibrosis tissue, Hematoxylin–Eosin and Masson's trichrome staining were used, respectively. Data were analyzed by using one-way analysis of variance (ANOVA) at P< 0.05 level. Results: The results indicated that subcutaneous injection of isoprenaline, induced myocardial infarction in rat heart tissue. Rate of necrotic lesion in the Endurance training group was significantly higher than Sedentary (control) group (P=0.005).        Also, the size of fibrosis tissue in the Endurance training group was significantly higher than the sedentary         (control) group (P= 0.001). Conclusion: In general, results of this study showed that 4 weeks of endurance exercise training after myocardial infarction exacerbate tissue injury in rat heart.}, Keywords = {Endurance training, Myocardial infarction, Morphological changes, Rat }, volume = {4}, Number = {1}, pages = {8-16}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.18869/acadpub.jbrms.4.1.8}, url = {http://jbrms.medilam.ac.ir/article-1-130-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-130-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Bimanand, Lida and Sadeghifard, Norkhoda and AziziJalilian, Farid and Hossainzadegan, Hassan and MohammadiDarbidi, Sattar and Hemahian, Ali and Ghafourian, Sobhan and Pakzad, Iraj}, title = {E-test antibiotic susceptibility of E.coli strains isolated from hospital acquired infections of Imam Khomeini hospital, Ilam, Iran}, abstract ={Introduction: Escherichia coli (E.coli) as a main cause of both nosocomial and community-acquired infections in humans have a relative potential to develop resistance. Nowadays, most infections caused by ESBL-producing E.coli (ESBLEC) had mostly been described as nosocomial acquired or nursing home related. In this study, we employed E-test assay to detect antibiotic resistance of E.coli strains and determine MIC of antibiotics. Materials and methods: Thirty E.coli strains gathered from Imam Khomeini hospital of Ilam, and cultured on TSB and bacterial suspension prepared by 0.5 µF concentration for E-test. Mueller Hinton agar and E-test strips of Amikacin, Cefepime, Ceftazidime, Ceftriaxone, Gentamicin, Meropenem, Nitrofurantoin, Piperacillin/Tazobactam, Tetracycline, Ticarcillin/ Clavulanic acid, Tobramycin, Trimethoprim were used Results: Resistance to Ceftriaxone, Tobramycin, Gentamicin, Ticarcillin/ Clavulanic, Amikacin were 19.8%, 26.4%, 23.3%, 62.7%, 70.3%, respectively. Conclusion: the results indicated, E.coli strains in this study were high sensitivity to Meropenem ,Nitrofuratoin, Ciprofloxacin , Ceftazidime, Cefepime.}, Keywords = {E-test, Antibiotic susceptibility, E.coli, Ilam, Iran}, volume = {4}, Number = {1}, pages = {17-21}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.18869/acadpub.jbrms.4.1.17}, url = {http://jbrms.medilam.ac.ir/article-1-158-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-158-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Mokhtari, Tahmineh and FaghirGhanesefat, Hedyeh and Hassanzadeh, Gholamreza and Moayeri, Ardeshir and Haeri, Seyed Mohammad Jafar and RezaeeKanavee, Alireza and MousaviMovahed, Seyyed Maji}, title = {Effects of Flaxseed oil supplementation on renal dysfunction due to ischemia/reperfusion in rat}, abstract ={Introduction: This study was designed to evaluate the effects of treatment with flaxseed oil (FSO) on renal ischemia-reperfusion (RIR) injuries in rats. Materials and methods: In this study, 32 Wistar rats were randomly studied in four groups: Co+NS (Control group with normal saline administration), Sh+NS (sham group with normal saline administration), RIR+NS and RIR+FSO. FSO (0.2 ml) was administered orally (gavage) for 14 days (~ 800 mg/kg body weight).  Blood samples were collected for the detection of blood urea nitrogen (BUN) and creatinine levels.  Malondialdehyde (MDA) and superoxide dismutase (SOD) levels were evaluated in the renal tissue. Tubular damages were examined using histopathological studies. Results: Significantly elevated MDA (P<0.05) and depressed SOD levels (P<0.05) Comparison between RIR+NS group and Control+NS and Sh+NS groups revealed in the condition of RIR. Treatment with FSO, however, significantly lowered the MDA (P<0.05) and enhanced SOD levels (P<0.05) after RIR injury. Histopathological results confirmed the biochemical studies and tubular necrosis score was reduced in the RIR+FSO group. Conclusion: This study therefore suggests that the aqueous flaxseed oil may be useful agents for the prevention of renal ischemia-reperfusion (RIR)-induced oxidative injury in rats.}, Keywords = {Flaxseed oil, Renal ischemia-reperfusion, Oxidative injury, MDA, SOD}, volume = {4}, Number = {1}, pages = {22-29}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.18869/acadpub.jbrms.4.1.22}, url = {http://jbrms.medilam.ac.ir/article-1-265-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-265-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Heidarizadi, Somayeh and Abbasi, Naser and Asadollahi, Khairollah and Rezaei, Sara and Moayeri, Ardeshir and Azizi, Monireh}, title = {Effect of olfactory ensheathing cells (OECs) transplantation on functional recovery in acute phase of spinal contused rats}, abstract ={Introduction: Spinal cord injuries (SCI) lead to permanent irreversible functional deficits.  Poor prognosis of patients is the motivation of searching a treatment for the chronic injury.  Planting stem cells provides us with a promising strategy. In the meanwhile, the use of olfactory ensheathing cells (OECs) has shown very good results.  This study aims at evaluating the effect of transplanted OECs on functional recovery of acute SCI in rats. Materials and methods: In this study, eighteen adult male Wistar rats weighting approximately 210 ± 10 gr were used to study spinal cord injury. They were randomly divided into four groups: Sham (n = 3), Control (n = 6), Vehicle (n=3) and Treatment (n=6). In the Sham Group, only laminectomy was performed in the area of T9 spinal cord. In three groups of Control, vehicle and Treatment, after laminectomy, spinal cord contusion model was performed using the Weight drop technique. Immediately after the injury, 10μl Dulbecco's Modified Eagle Medium (DMEM) alone or with 106 cells were injected to vehicle and Treatment Group animals. For culturing cells, the olfactory mucosa of 7-day-old male Wistar rats was used. Motor function of animals in all groups, was evaluated in the first 48 hours daily and then weekly for eight weeks. Results: Comparing the results of the second to eighth week of the study showed significant differences in the group receiving the OECs with the control group (P<0.05). Conclusion: The results indicate a positive influence of the olfactory ensheathing cells in functional improvement of spinal cord injury in the acute phase of injury.}, Keywords = {Spinal cord injury, Olfactory ensheathing cells }, volume = {4}, Number = {1}, pages = {30-36}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.18869/acadpub.jbrms.4.1.30}, url = {http://jbrms.medilam.ac.ir/article-1-192-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-192-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Soheili, Bahareh and Mirzaei, Amin and Sayemiri, Kourosh and Ghazanfari, Zeinab}, title = {Predicting the behavioral intention of pregnant women’s choice of delivery method based on the theory of planned behavior: A cross-sectional study}, abstract ={Introduction: Cesarean, as a major abdominal surgery, if done without a medical indication, may impose numerous complications on the mothers and the babies and increase frequency of cesarean deliveries in subsequent pregnancies. This study aimed to predict the behavioral tendencies of pregnant women in selecting their delivery approaches, based on the theory of planned behavior (TPB). Materials and methods: This cross-sectional study was performed on 100 pregnant women referred to healthcare centers of Kermanshah city (western Iran). A researcher-made questionnaire was applied, based on TPB constructs including attitudes, perceived behavioral controls, subjective norms, and behavioral tendencies. To analyze the data, Pearson correlation, Spearman, s regression, and ANOVA were used via the SPSS statistical software, version 20. Results: The average age of pregnant woman was 23.7±3.93 years old. The results demonstrated a significant correlation between the subjective norms and behavioral tendencies (r=0.335, P=0.001). A significant relationship was seen between the perceived behavioral controls and tendencies (r=0.277, P=0.004). A significant relationship was found between the perceived behavioral control and the attitude (r=0.293, P=0.002). The results of the regression results demonstrated that the subjective norms and perceived behavioral controls can significantly predict 14.1 percent of changes in the variable of tendencie. Conclusion: The findings indicate the strength of the variable of subjective norms as the most effective factor in predicting the delivery approach; therefore, systematic and planned training seems necessary, not only for the pregnant women, but also the individuals affecting this group. Thus, to reduce caesarean sections, physicians, as an effective factor, need to be urged to boost natural childbirth.}, Keywords = {Natural childbirth, Cesarean section, Theory of planned behavior, Pregnant women}, volume = {4}, Number = {1}, pages = {37-44}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.18869/acadpub.jbrms.4.1.37}, url = {http://jbrms.medilam.ac.ir/article-1-225-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-225-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Aryaie, Mohammad and Khombehbini, Zahra and Bakhsha, Fozieh and Yousefi, Zahra and Behravesh, Omi}, title = {Psychological factors related to musculoskeletal pain among Iranian female adolescents}, abstract ={Introduction: Musculoskeletal pain accompanied by psychological problem lead to reduce the efficiency of adolescents; so, this study aimed to determine the prevalence of musculoskeletal pain and its association with psychological factors among female adolescents. Materials and methods: The target population of this cross sectional study was female students (3625 in total) from both private and state funded high school children in Gorgan, northern Iran. Self - assessment questionnaires were distributed to 255 students across 8 female high schools. Self-report version of the Strengths and Difficulties (SDQ) questionnaires was used to screen adolescents with Psychiatric symptoms. To evaluate musculoskeletal pain Nordic questionnaire and numeric pain rating scale was used. Data were analyzed by binary logistic regression and the cumulative odds ratio (COR) was carried out for the ordinal level of musculoskeletal symptoms. Results: The prevalence rate of neck, shoulder and low back pain was reported, 23.1%, 27.8% and 27.7%, respectively.  Hyperactivity-inattention (OR=2. 82; CI: 1.14-6.97) and peer problem (OR= 2.72; CI: 1.01-7.32) had significant relationship with neck pain, and prosocial behaviors (OR= 3.11; CI: 1.09-10.73) were associated with low back pain in the multivariate model. Ordinal regression showed that the increasing numbers of musculoskeletal symptoms related only to prosocial behavior (COR= 2.78; CI: 1.12-6.91). There was no significant association between shoulder pain and psychological factors. Conclusion: Based on the results, psychological factors were associated with musculoskeletal pain; so, it seems suffering from musculoskeletal pain need to be concurrently noticed with mental feeling for more effective response to attenuate pain.}, Keywords = {Psychological problems, Neck, Shoulder, Low back pain}, volume = {4}, Number = {1}, pages = {45-52}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.18869/acadpub.jbrms.4.1.45}, url = {http://jbrms.medilam.ac.ir/article-1-76-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-76-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Mohsenzadeh, Yousof and Motedayen, Morteza and Hemmati, Farhad and Sayehmiri, Kourosh and Sarokhani, Mohammad Taher and Sarokhani, Di}, title = {Investigating the prevalence rate of hypertension in Iranian men and women: A study of systematic review and meta-analysis}, abstract ={Introduction: Based on the serious complications which are followed, hypertension is a common and asymptomatic health problem. This study aims to present a general statistics of the rate of the prevalence of systolic and diastolic hypertension in Iranian men and women based on the age range through the systematic review and meta-analysis method. Materials and methods: In this study of systematic review and meta-analysis, some databases such as Google Scholar, Scope.com, Magiran, Iran Medex, Medlib, Sid, and Pubmed were searched by using keywords such as hypertension, men and women, Iran, and prevalence. The first and the last published articles in this field were in 1999 and 2012, respectively. Data were combined by random effects meta-analysis model and they were analyzed by STATA11. Results: From 100 articles which were found in the searched references, 22 of them were finally analyzed. Among the selected final articles from 1999 to 2012, 96689 subjects were used in this study. The mean prevalence of hypertension was 17% (confidence coefficient of 95%, 17-17%). The prevalence rate of hypertension among the people above 20 was between 10-32% and its mean was 24% (confidence coefficient of 95%, 23-24%). The mean prevalence of hypertension among the people below 20 was 5% (confidence coefficient of 95%, 4-5%). Conclusion: In the studies done in Iran, the prevalence rate of hypertension was high. Noticing that hypertension is an important and dangerous factor for cardiovascular diseases, it is a worrying issue in Iran and it is necessary to be programmed in order to control and prevent this disease.}, Keywords = {Hypertension, Men and Women, Iran, Prevalence }, volume = {4}, Number = {1}, pages = {53-62}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.18869/acadpub.jbrms.4.1.53}, url = {http://jbrms.medilam.ac.ir/article-1-195-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-195-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Naghshineh, Elham and Mostaghaci, Mehr}, title = {Successful treatment of thrombotic thrombocytopenic purpura during pregnancy: A case report}, abstract ={A 28 years’ pregnant woman with 24 weeks’ gestational age referred with petechiae and purpura from previous day without any trauma. She had an occipital headache from last night. Overt petechial and purpuric lesions were seen in the mouth and skin. There was neither hepatosplenomegaly nor lymphadenopathy. She was conscious and oriented. The patient was febrile, anemic and thrombocytopenic with stable vital signs. All liver enzymes were elevated. Coagulation profile was normal. WBCs were normal. RBCs were reduced, and she had polychromatosis. Overt shistocytosis was seen. Platelets were significantly decreased. The first diagnosis was TTP. All necessary laboratory tests were done to rule out the secondary rheumatologic causes of TTP; which all were normal. Coombs tests were negative. ADAMTS 13 Ab was elevated. Fetal ultrasonography was normal. Treatment started with plasmapheresis and corticosteroid. After treatment, platelets count begins elevated, and LDH decreased. The patient discharged with a good general condition and normal lab tests. She continued her pregnancy until term, and born a normal infant without any complication. She did not have a recurrence of TTP until September 2014.}, Keywords = {TTP, Pregnancy, Treatment }, volume = {4}, Number = {2}, pages = {1-3}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.18869/acadpub.jbrms.4.2.1}, url = {http://jbrms.medilam.ac.ir/article-1-88-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-88-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Boustani, Hasan and Anvari, Enayat and SaiadiSartang, Sedighe and Omidi, Mehdi and Rostami, Esmaeil and Mohamadi, Zahr}, title = {Prevalence of HIV, hepatitis B and C infections among volunteer blood donors at the blood transfusion center of Ilam city, Iran}, abstract ={Introduction: Blood derived products have been known as an effective treatment for many years. However, this treatment is not without risk of infections transmission including hepatitis B virus (HBV) and hepatitis C virus (HCV) and human immune-deficiency virus (HIV) in people who received the blood. Nevertheless, due to a high risk of blood born diseases through blood transfusion, screening for these viruses according to the World Health Organization (WHO) is mandatory. The main aim of this research was to assess the prevalence of HBV, HCV and HIV infections among healthy blood donors of Blood Donor Center of Ilam (BDCI). Materials and methods: In this study we used the information from first and repeated blood donors who referred to BDCI within February 2009 to January 2013. Demographic characteristics of donors including marital status, age, gender and blood donation pattern was extracted. Routine donor laboratory screening tests for HBV, HIV and HCV were performed. Results: HBV infection had the highest prevalence (0.14%) while HIV had the lowest ones (0.006%). The highest prevalence was among male blood donors. The prevalence of HBv, HIV and HCV infections were more common among men and first time donors (P < 0.01). The prevalence of  HIV and HCV infections were more common among married donors than singe ones (P < 0.01) HBV prevalence in singles was more (P < 0.05) compared to married blood donors. The highest and the lowest subjects with HBV, HCV and HIV infections were in range of 51 to 60 years and 18-35 years old, respectively. Conclusion: It is estimated that the prevalence of HBV, HCV and HIV infections are low in voluntary blood donors than general population which confirmed the effectiveness of education and examination of blood donors. This usually arising from the pre donation screening for risky behaviors, so deleting the high risk people. Since unsafe blood products are not used for blood transfusion, they are not considered as risk for blood safety system, but identification of these blood units is a problem for blood transfusion centers.}, Keywords = {Blood donor, Ilam City, Hepatitis B virus, Hepatitis C virus, HIV}, volume = {4}, Number = {2}, pages = {4-8}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.18869/acadpub.jbrms.4.2.4}, url = {http://jbrms.medilam.ac.ir/article-1-222-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-222-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Aryaie, Mohammad and Bakhsha, Fozieh and Jafari, Seyyed Yaghub and Yousefi, Zahra and Heidari, Ali Reza and Esmaeili, Zahra and Sobhani, Sakineh and Aghili, Shim}, title = {The short-term survival following acute myocardial infarction: A prospective observational study}, abstract ={Introduction: To investigate 28 days survival rate following first acute myocardial infarction (AMI) associated with the presence of classical risk factors and treatment modalities in Gorgan, north of Iran. Materials and methods: Our cohort including all patients hospitalized due to AMI from 2010 to 2013. Data were collected on demographic, prophylactic drugs and classical coronary risk factors. Data were analyzed using Kaplan-Meier and log rank tests. Cox proportional hazard model was built to estimate relative risk by taking into account other variables. Results: Median age of subjects was 58 and 64 for men and women, respectively; moreover, the occurrence of diabetes was 52.5 and 24.5 for them. A poorer outcome was detected in survival rate for women in the final model. Excess death occurrence in Fars or non- Persian ethnicity, and those who were not prescribed statin was detected in the adjusted model. Conclusion: A better survival rate for those who were prescribed statin suggest that it could be beneficial in treatment modality and non-Persian ethnicities needed to be considered as a group of at risk for earlier screening programs. In spite of some other studies a poorer outcome following AMI for women was found even after taking into account age and comorbidity.}, Keywords = {Acute myocardial infarction, Survival, Risk factor, Treatment}, volume = {4}, Number = {2}, pages = {9-16}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.18869/acadpub.jbrms.4.2.9}, url = {http://jbrms.medilam.ac.ir/article-1-78-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-78-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Rezaei, Sara and Bakhtiari, Salar and Asadollahi, Khairollah and Heidarizadi, Somayeh and Moayeri, Ardeshir and Azizi, Monireh}, title = {Functional recovery assessment of spinal cord contusion model in male rats without therapeutic interventions}, abstract ={Introduction: Spinal cord injury (SCI) is one of the most serious clinical diseases, which not only affects the patient's physical and mental status, but its effects will be spread to family and community. After severe spinal cord injury, astrocytes of the central nervous system (CNS) become reactive astrocytes, and play the main role of glial scar formation. The scar is a major obstacle to regeneration of axons in the spinal cord. However, the studies have found that over time, a spontaneous partial motor recovery is observed in animals with injury without intervention. Thus, in this study, the recovery of animals with spinal cord injury was assessed after 12 weeks. Materials and methods: In this study, 12 adult male Wistar rats weighing approximately   265±15gr were used to assess spinal cord injury and randomly divided into 3 groups: normal control (n = 3), sham (n = 3), injury (n = 6). Healthy animals in the normal control group received no laminectomy or injury, and laminectomy with or without contusion model using weight drop in segment T10 of spinal cord were carried out in injury and sham groups, respectively. Locomotor function of animals in all groups were evaluated by BBB test at the first 48 hours per day and then weekly for 12 weeks. Results: Comparison of the results of motor evaluation from the second week to the twelfth week of the group with injury without treatment showed a relative functional recovery as the BBB score of animals from 1.4 in the second week after the injury reached to 6.5 in the twelfth week. Conclusion: The results indicate a spontaneous partial recovery in injured animals without intervention.}, Keywords = {Spinal cord injury, Glial scar, Functional recovery, Rat}, volume = {4}, Number = {2}, pages = {17-23}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.18869/acadpub.jbrms.4.2.17}, url = {http://jbrms.medilam.ac.ir/article-1-193-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-193-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {LoueiMonfared, Ali and Shamsi, Mortez}, title = {The effect of lansoprazole administration during pregnancy on the placenta}, abstract ={Introduction: Lansoprazole is one of the proton pump inhibitor drugs widely used in the treatment of gastro-duodenal ulcers and disorders. However, there is not enough data about unexplored adverse effects of lansoprazole on the integrity of the placental barrier. Therefore, the present study was conducted to determine whether placental structure could be affected by lansoprazole administration. Materials and methods: A total of 24 pregnant Balb/C mice were randomly divided into one control and three experiment groups (n=6).The experimental animals were given 25, 50 and 100 mg/kg of lansoprazole intraperitoneally on days 6-16 of pregnancy. At the end point and on the day 17 of gestation all animals were sacrificed. Then, the placentas specimens were taken and processed for histological examinations. Histological sections were stained with hematoxylin-eosin and were examined under light microscopy. Results: The histological examinations showed remarkable cellular changes in the placenta after treatment with lansoprazole. The placentas from drug administrated mice exhibited conspicuous decrease in the spongy layers size when compared with controls. Also, both polymorph and mononuclear cell infiltration into placental parenchyma were seen in the animals treated with 100 mg/kg lansoprazole. In addition, dilation of the intervillous space, massive vasculature congestion, increased giant cell population and fibroblastic proliferation were seen in the placental tissues from experimental groups. Conclusion: The findings of the present study led us to investigate the effect of the lansoprazole administration on the mouse placenta. Taken together, this drug should not be prescribed during pregnancy.}, Keywords = {Histology, Placenta, Mouse, Lansoprazole, Health}, volume = {4}, Number = {2}, pages = {24-28}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.18869/acadpub.jbrms.4.2.24}, url = {http://jbrms.medilam.ac.ir/article-1-268-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-268-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Nademi, Mohsen and KeshavarzMoraveji, Mostafa and Mansouri, Mohse}, title = {Investigation of UV/TiO2-N photocatalytic degradation of AR 40 using response surface methodology (RSM)}, abstract ={Introduction: Advanced oxidation processes (AOPs) suggest a highly reactive, nonspecific oxidant namely hydroxyl radical (OH•), that oxidize a wide range of pollutants fast and non-selective in wastewater and water. Materials and methods: In this work, the nitrogen-doped titanium dioxide nanoparticles were primed by sol-gel method, characterized by X-ray diffraction and Scanning Electron Microscopy (SEM), for the degradation of Acid Red 40 (AR 40) solution in water. The effectiveness of the treatment method applied for the degradation of AR 40 based on AOPs was investigated. Results: The three various key parameters were optimized by using response surface modeling, namely: pH, TiO2-N concentration and the initial AR 40 concentrations. The optimized values were obtained at pH = 11, TiO2-N concentration = 0.09 g/L, and the initial AR 40 concentration = 19 mg/L. Conclusion: Under the optimum conditions, performance of photocatalytic degradation reaches 92.47% in 1 hr. Kinetic constant was evaluated using first-order equation to obtain the rate constant, K.}, Keywords = {Photocatalytic degradation, AR 40, TiO2-N nanoparticles, Response surface modeling}, volume = {4}, Number = {2}, pages = {29-40}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.18869/acadpub.jbrms.4.2.29}, url = {http://jbrms.medilam.ac.ir/article-1-260-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-260-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Ebrahimi, Himan and Shahrokhi, Mehdi and Barmar, Zahra Toktam and Balouchi, Rami}, title = {The impact of fatigue on balancing in creating re-injuries in mountaineers with chronic ankle sprain}, abstract ={Introduction: Sensory-motor control and in general gaining balance will be impaired after an ankle injury and in fatigue situations. The aim of this research was to study the effect of exercise-based fatigue on static and dynamic balance in mountaineering athletes who were successful in returning to a suitable level of physical activity after an ankle sprain injury. Materials and methods: 25 active mountaineering athletes between 20 and 40 years were recruited on a voluntary basis. 12 persons with severe ankle sprain in the past were selected as experimental group and 13 healthy mountaineering athletes were selected as control group. Because balance test measuring was under the influence of evaluation time; fatigue test measurement running on the treadmill was performed in 2 sessions. Changes or fluctuations in the pressure Center or static balance were evaluated by Sharpened Romberg balance test and dynamic balance was evaluated by stability time after side jumping (the first session) and the maximum distance in the balance test Y (second session) were evaluated in the pre-test and post-test immediately after fatigue resulted by running on a treadmill. Data were analyzed using covariance test. Results: before fatigue condition, there were a few differences between the two groups in stability time while doing side jump test (P<0.014). After the fatigue and in balance test Y and stability time while doing side jump test; there were more differences (P<0.001). In this case, there was a similar increase on static swing in both groups. Fatigue was considerably reduced the static and dynamic postural control of the athletes who had a history of injury. Changes related to fatigue was significant in dynamic postural control in athletes with previous ankle sprain history. Conclusion: Even after the successful return to sport for athletes with previous damages, abnormalities in sensory-motor control and balance may lead to an increase the risk of ankle re-injury.}, Keywords = {Ankle sprain, Balance, Fatigue, Mountain climbers}, volume = {4}, Number = {2}, pages = {41-49}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.18869/acadpub.jbrms.4.2.41}, url = {http://jbrms.medilam.ac.ir/article-1-183-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-183-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {MirzaeeKhalilabadi, Roohollah and Yari, Fatemeh and Amirizadeh, Naser and Nikougoftar, Mahin and Oodi, Arezoo}, title = {Mesenchymal stem cells as a reference cell for HLA-typing}, abstract ={Introduction: Recognition of human leukocyte antigens (HLA) is of importance for hematopoietic stem cell transplantation. Any HLA-mismatches between the donor and recipient can cause graft rejection or other complications. In HLA-typing experiments, usage of HLA-known reference cells accompany with HLA-unknown samples is obligatory. Some international centers represent these cells with high expenses. On the other hand, transferring of these cells is problematic and in some instances is not practical.  In this study, we introduced umbilical cord-derived mesenchymal stem cells (MSCs) as reference cells for HLA genotyping. These cells are national and can be prepared locally. Materials and methods: We isolated MSCs from three umbilical cord and after their growth and proliferation, these cells were characterized by flow cytometry technique using antibodies to CD29, CD34, CD44, CD45, CD73, CD90 and CD105. HLA-typing was then carried out by PCR-SSP kits for HLA-A, -B and -DRB allele’s identification. Results: Isolated MSCs were positive for MSCs markers; CD29, CD44, CD73, CD90, and CD105 and negative for hematopoietic stem cell markers; CD34 and CD45. HLA alleles were determined. One of the samples was homologous for HLA alleles and the others were heterologous. Conclusion: We can develop a reference panel for HLA-typing by obtaining MSCs from available sources like umbilical cord.}, Keywords = {HLA-typing, Mesenchymal stem cells, Reference panel, Umbilical cord}, volume = {4}, Number = {2}, pages = {50-57}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.18869/acadpub.jbrms.4.2.50}, url = {http://jbrms.medilam.ac.ir/article-1-227-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-227-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Nemattalab, Mehran and Shenagari, Mohammad and Mojtahedi, Ali and Aghasadeghi, Mohammad Reza and Pouriayevali, Mohammad Hassan and Taheri, Mojtaba and Mondannizadeh, Mahdieh}, title = {Design, cloning and expression assay of oipA gene in a bicistronic vector harboring mice IL-18 gene: potential implications for Helicobacter pylori vaccine investigations}, abstract ={Introduction: Helicobacter pylori (H. pylori) infection has remained as a global health problem. Animal studies demonstrated the role of H. pylori oipA gene in the development of gastric cancer. The aim of this study was the cloning and expression of Helicobacter pylori oipA gene in a bicistronic vector harboring mice IL-18 gene. Materials and methods: The target gene encoding oipA was amplified from a codon-optimized clone by PCR, and then double-digested by restriction enzymes. The pIRES-Igk/mIL18/Fc plasmid was simultaneously digested by BstXI/NotI enzymes to elicit the eGFP segment. PCR product of oipA was inserted into pIRES-Igk/mIL18/Fc plasmid using T4 ligase. Transformation into DH5α strain was done. Cloning was confirmed by PCR, enzymatic digestion and sequencing. Expression of the oipA and IL-18 mRNA was assessed by means of TaqMan Real-time PCR. Results: Electrophoresis of PCR product, enzymatic digestion and sequencing showed that the H. pylori oipA gene was successfully cloned into pIRES-Igk/mIL18/Fc to generate mIL-18-pIRES2-oipA plasmid. The results of Real-time PCR confirmed the successful expression of both oipA and IL-18 in mouse macrophage cell line. Conclusion: Considering the role of oipA in pathogenesis of H. pylori and potent activity of IL-18 as a molecular adjuvant, the results of the present study showed that the expression of codon-optimized oipA gene in bicistronic vector including mouse IL-18 is successful. So, it could be considered as an appropriate genetic vaccine candidate for H. pylori in future investigations.}, Keywords = {Cloning, Codon-optimization, oipA gene, Mouse IL-18, Bicistronic vector }, volume = {4}, Number = {3}, pages = {1-7}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.4.3.1}, url = {http://jbrms.medilam.ac.ir/article-1-255-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-255-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Mohammadi, Iman and Thaghinejad, Hamid and Suhrabi, Zainab and Tavan, Hame}, title = {The correlation of learning and study strategies with academic achievement of nursing students}, abstract ={Introduction: One of the most important problems in student's education is academic failure. Identifying factors that affecting academic achievement and pay attention to these factors is a stride toward success. Students' academic achievement and related factors have priority in education research. This study aimed to determine the relationship between learning study strategies and academic achievement of nursing students in 2013. Materials and methods: This descriptive- analytic study was performed among 85 nursing students of Ilam University of Medical Sciences. By using the learning and study strategies inventory (LASSI), the main three components of study and learning strategies, including items of skill, will and self-regulation were examined. The Pearson correlation was used to measure students' academic achievement correlation with the mentioned above components. Results: The sample consisted of 50.6% female and 49.4% male. The mean grade of nursing students was scored 15.60. Pearson correlation coefficient showed that the three main components of learning strategies and study skills component, respectively skill (P=0.001, r=0.349), self-regulation (P=0.009, r=0.280) and the component of will (P=0.045, r=0.218) with student achievement (mean grade of last term) had a positive and significant relationship. Conclusion: Considering positive and significant correlation between learning and study strategies with academic achievement in nursing students, so, we suggest that students and teachers use these strategies to improve academic achievement and reduce the academic loss of students.}, Keywords = {Study strategies, Learning, Nursing students, Academic achievement }, volume = {4}, Number = {3}, pages = {8-13}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.4.3.8}, url = {http://jbrms.medilam.ac.ir/article-1-217-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-217-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {AlipourParsa, Saeed and Saki, Behzad and Ebrahim, Khosrow and Raeisolsadat, Seyed Ahm}, title = {The rehabilitation training and antioxidant status in patients with myocardial infarction}, abstract ={Introduction: Myocardial infarction (MI) is associated with increased oxidative stress and reduced antioxidants. Some studies have shown that exercise training increases the serum level antioxidants. Therefore, this study investigated the effect of rehabilitation training on antioxidant status in patients with myocardial infarction. Materials and methods: In this study, 20 patients with myocardial infarction were selected and randomly assigned to training group (n=10) or control group (n=10). Training program included 3 sessions of concurrent training per week for eight consecutive weeks. To measure the values of malondialdehyde (MDA), protein carbonylation (PC) and total antioxidant capacity (TAC), 10 ml of blood were taken pre- and post-training in each patient. The t-test was used to analyze the data. P<0.05 was considered significant in all tests. Results: The data showed that 8 weeks of rehabilitation training significantly reduces MDA (2.37±0.59 µM and 3.74±1.34 µM in training and control groups, respectively; P=0.000) and PC (9.15±1.77 nmol/mg protein and 11.48±1.60 nmol/mg protein in training and control groups, respectively; P=0.006) levels and significantly increases TAC (10.09±1.70 U/ml and 8.34±1.56 U/ml in training and control groups, respectively; P=0.031). Conclusion: Since the findings of the present study show a reduction in oxidative stress markers (MDA, PC) and an increase in total antioxidants capacity, it seems that eight weeks of concurrent training may improve the antioxidant capacity in patients after myocardial infarction.}, Keywords = {Rehabilitation, Oxidants, Antioxidants, Myocardial infarction}, volume = {4}, Number = {3}, pages = {14-18}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.4.3.14}, url = {http://jbrms.medilam.ac.ir/article-1-279-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-279-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Musavimoghadam, Seyed Rahmatollah and Sari, Tahereh and Heidarihasanabadi, Shiri}, title = {The relationship of spiritual understanding and self-esteem with suicidal thoughts}, abstract ={Introduction: Spirituality, as with the knowledge of the whole universe, is a force beyond the material aspects of life. Self-esteem is generally a component of evaluation of self-concept and the suicidal thoughts is a condition that implies on the occurrence of any self-destructing thoughts. Materials and methods: Methodology of the present study was descriptive and correlational. The study population included all graduate students of Azad University of Ilam from which 235 persons (138 men and 97 women) were selected through stratified random sampling. The measuring tools of data were as follow: Kings spiritual understanding questionnaire, Eysenck self-esteem questionnaire and Beck suicidal ideation scale. The data was analyzed with using the statistical software SPSS the statistical methods, Pearson correlation coefficient, analysis of variance, multiple regression analysis and structural equations. Results: Spiritual understanding and self-esteem reversely and significantly predicted the thoughts of suicide with the coefficients -0.194 and -0.077, respectively. Conclusion: Individual factors such as spiritual perception and self-esteem are important and effective on the mental aspects of students. By increasing the impact of these factors, it could be expected to reduce the number of suicides.}, Keywords = {Suicidal thoughts, Spiritual understanding, Self-esteem, Students }, volume = {4}, Number = {3}, pages = {19-25}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.4.3.19}, url = {http://jbrms.medilam.ac.ir/article-1-263-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-263-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Yaftian, Morteza and Yari, Fatemeh and Ghasemzadeh, Mehr}, title = {Induction of apoptosis in human tumor cell lines by platelets}, abstract ={Introduction: It has been reported that platelets can eradicate tumor cells in vitro, although the mechanism of this effect has not been determined. The effect of platelets on the induction of apoptosis in tumor cells is largely unknown. Materials and methods: To investigate this effect, two human hematologic cell lines, K562 and Daudi, were independently faced with unstimulated and thrombin-activated platelets. After the elapsed co-culture time, the levels of caspase-3 and CD95 were evaluated as a sign of cell death and apoptosis. In addition, immortalized cells were evaluated using trypan blue, 7-AAD and WST-1 methods. Results: CD95 and caspase-3 levels were significantly increased in both cell lines compared with the control cells (P<0.05). Beside, considerably lower number of living cells were shown by trypan blue, 7-AAD and WST-1 in the treatment groups compared with the control group (P<0.05). Conclusion: This study demonstrated the role of apoptosis in tumor inhibition and implied the ability of platelets to induce apoptosis in tumor cell lines.}, Keywords = {Apoptosis, Platelet, K562, Daudi, CD95}, volume = {4}, Number = {3}, pages = {26-33}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.4.3.26}, url = {http://jbrms.medilam.ac.ir/article-1-257-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-257-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Khayyati, Zahra and Yari, Fatemeh}, title = {Isolation and purification of HLA-DR antigen from Daudi cell line by immunoaffinity chromatography}, abstract ={Introduction: The major histocompatibility complex (MHC) is a group of cell surface proteins that are essential for recognizing foreign molecules in human and other mammals. The physiologic function of MHC molecules is the presentation of peptides to T cells. In this study, we evaluated the purification of a class II MHC molecule (HLA-DR) from a human Burkitt′s lymphoma cell line; Daudi. Materials and methods: We described a simple procedure for purifying human HLA molecules from the cells lysate. As a representative model, HLA-DR was purified from Daudi cell line. The cell membrane was solubilized by a buffer contained NP-40 detergent. Subsequently, the isolation of the membrane antigen was carried out by affinity chromatography method using mouse anti-human HLA-DR monoclonal antibody. The size and the specificity of the purified antigen were determined by Bradford and ELISA methods, respectively. Results: The purified HLA antigen was obtained in approximately 20-30 micrograms in each run of chromatography. Additionally, ELISA method demonstrated the HLA-DR specificity of the purified protein.   Conclusion: The results indicated that affinity purification of HLA-DR antigen by means of specific monoclonal antibody is a simple and fast procedure for obtaining the purified antigen.}, Keywords = {HLA-DR, Affinity chromatography, ELISA}, volume = {4}, Number = {3}, pages = {34-38}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.4.3.34}, url = {http://jbrms.medilam.ac.ir/article-1-281-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-281-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Keshavarzi, Fatemeh and Ashtari, Parviz and Ebrahimi, Pirooz}, title = {Evaluating the serological applications of Toxoplasma gondii rhoptry protein 1 (ROP1) antigen}, abstract ={Introduction: Toxoplasma gondii (T. gondii) is distributed worldwide and infects most species. The serious incidence and severe or fatal injury caused by T. gondii infection clearly indicates the necessity for the event of a vaccine. The current study goals were to evaluate serological applications of Toxoplasma gondiirhoptry protein 1 (ROP1) antigen. Materials and methods: We created a polymer vaccine by using the eukaryotic plasmid, pROP1. Purification by one-step metal affinity chromatography allowed recovery of milligram amounts of purified recombinant proteins per liter of culture. The quality of this matter for diagnosing of human infections was provided and tested on 77 serum samples which were obtained during routine diagnostic tests. A panel of 20 serum samples from patients with acute toxoplasmosis was compared to a panel of 35 serum samples from individuals with chronic toxoplasmosis. Results: Results of the study indicated that antibodies detected from patients with acute and chronic infections were 96% and 17%, respectively, by using of pROP1 recombinant antigen. Conclusion: According to the present study an immunoglobulin G antibody against ROP1 antigen is made throughout the acute stage of toxoplasmosis infection, but not in the chronic phase of toxoplasmosis.}, Keywords = {Toxoplasma gondii, ROP1, Recombinant antigen, Acute toxoplasmosis}, volume = {4}, Number = {3}, pages = {39-41}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.4.3.39}, url = {http://jbrms.medilam.ac.ir/article-1-261-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-261-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Mahmoudi, Mohammad-Reza and Bandepour, Mojgan and Kazemi, Bahram and Mirzaei, As}, title = {Detection and enumeration of Cryptosporidium oocysts in environmental water samples by Real-time PCR assay}, abstract ={Introduction: The protozoan parasite, Cryptosporidium Spp., widely spreads in both raw and drinking waters. It is the causative agents of waterborne diarrhea and gastroenteritis in the world. In the present study, a molecular assay was used for the detection and quantification of Cryptosporidium oocysts in environmental water samples. Materials and methods: Thirty surface water samples were collected from Rasht City rivers and lagoons during 2009-2010. The samples were analysed for Cryptosporidium oocysts using Real Time PCR method. Samples were filtrated through a 1.2µm pore size cellulose nitrate membrane filter and then purified and quantified by Real-time PCR technique. Results: Cryptosporidium oocysts were found in 19 of 30 the samples. Oocyst concentration was ranging from 0.007 to 27 oocysts per liter of the examined waters. Conclusion: The present study showed that the investigated water supplies were contaminated by Cryptosporidium oocyst. This study indicated that in this level of oocysts there is a potential risk of waterborne cryptosporidiosis due to direct or indirect consumption of these waters by humans and animals. Real-time PCR is a technique that provides high sensitivity for detection quantitative purposes.}, Keywords = {Cryptosporidium spp., Water, Iran, Real-time PCR}, volume = {4}, Number = {3}, pages = {42-47}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.4.3.42}, url = {http://jbrms.medilam.ac.ir/article-1-299-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-299-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Asgari, Parvaneh and Bahramnezhad, Fatemeh and Golitaleb, Mohammad and Salehi, Fatemeh and Mokhtari, Razieh and Rafiei, Fatemeh}, title = {Effect of Glycyrrhiza glabra extract and aerobic exercise on the attitude of postmenopausal women to menopause}, abstract ={Introduction: Menopause is associated with complications that can affect women's attitudes. Women's attitudes toward menopause can help to improve their performance and reduce the severity of its complications. The aim of this study was to evaluate the effect of Glycyrrhiza glabra (G. glabra) plant and exercise on the attitude of menopausal women. Materials and methods: This clinical experimental fourth group was conducted between October and March 2015 in Arak, Iran. 120 menopausal women were randomly selected and divided into four groups each containing 30 women. The first group had three G. glabra tablets daily for one month, the second group had a regular exercise program three times a week for 30-45 minutes for one month and the third group simultaneously took G. glabra like Group1 and followed exercise programs like Group 2 and the fourth group received no intervention. Before and one month after the intervention attitudes of women were compared with a researcher-made questionnaire. ANOVA, Chi-square and Paired t tests were used to analysis the data. Results: The results showed no significant difference between four groups in demographic characteristic. ANOVA results showed no significant difference between four groups in the attitude score of women before the intervention (P=0.937), but after the intervention there were significant differences between the groups (P=0.0001). Conclusion: According to the results, G. glabra consumption and exercise program were effective in controlling the symptoms of menopause attitude of menopausal woman. Therefore, it may proposed as one of the main strategies for health and education interventions.}, Keywords = { Glycyrrhiza glabra, Exercise, Attitude, Menopause}, volume = {4}, Number = {4}, pages = {1-7}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.4.4.1}, url = {http://jbrms.medilam.ac.ir/article-1-243-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-243-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Rostami, Esmaeil and Ayatollahi, Hossein and Boustani, Hassan and Ghotaslou, Abbas and Sadeghian, Mohammad Hadi and Keramati, Mohammad Reza and Zeinali, Elahe and Rad, Abolfazl}, title = {Evaluation of PPP2R5C gene expression in Iranian patients with B-Acute lymphoblastic leukemia and its association with clinical and laboratory findings}, abstract ={Introduction: PPP2R5C is one of the regulatory B subunits of protein phosphatase 2A (PP2A), which is a tumor suppressor. PPP2R5C plays a critical role in cell proliferation, differentiation, and transformation. Considering these vital functions, we investigate the gene expression in Iranian patients with B-Acute Lymphoblastic Leukemia (B-ALL) and its association with clinical and laboratory finding. Materials and methods: In this case-control study, peripheral blood samples were collected from 60 B-ALL patients and 30 healthy controls. PPP2R5C expression levels were determined by Real-time PCR. After calculation of CT for target and control genes, we calculated ΔCT. Finally we compared the PPP2R5C expression levels in patients with control group. Results: Significantly higher expression of PPP2R5C was found in the B-ALL patients (2.15±2. 50) compared with control group. There was no correlation between PPP2R5C expression and clinical and laboratory findings and FAB (French-American-British) subtype of patients. Conclusion: we demonstrated PPP2R5C overexpression in B-ALL patients. Although there was no significant correlation between PPP2R5C expression, clinical and laboratory finding and also with FAB subtypes of patients.}, Keywords = {B-Acute Lymphoblastic Leukemia, PPP2R5C, PP2A, Gene expression}, volume = {4}, Number = {4}, pages = {8-12}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.4.4.8}, url = {http://jbrms.medilam.ac.ir/article-1-287-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-287-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Vosoughi, Pegah and Keshavarzi, Fatemeh and Ashtari, Parviz}, title = {The prevalence of chromosomal translocation t (1; 4) (p21; p14) in Iranian patients with mental disability}, abstract ={Introduction: Intellectual disability or intellectual retardation is a condition in which total mental functioning is distinctively below average and there are disabilities in adaptive behaviors during growth. According to the definition of American Mental Disability Community in 1992 a person is considered intellectually disabled if he or she has an IQ (intelligence quotient) of less than 70 and has a limitation in one or multiple adaptive skills. There are many different causes of intellectual disability that one of them is the genetically and chromosomal abnormalities. The aim of this paper was to study translocation breakout t (1; 4) (p21; p14) in a number of mental retardation patients in Iran. Materials and methods: This descriptive study was carried out on 100 persons with light mental disability by using cytogenetic methods. Lymphocytes were cultured in the dedicated environment by G-Banding karyotype of each person after obtaining patient’s blood sample. The data were statistically analyzed by logistic regression. Results: The findings showed that none of the patients with a mental disability was afflicted to the chromosomal translocation, (1; 4) (p21; p14). Conclusion: The lack of translocation in this study was equivalent with the obtained frequency in the same studies which have been carried out on the subjects suspected to have a translocation. Also, it seems that chromosomal analysis may be a usefulness diagnostic tool for children with mental retardation.}, Keywords = {Mental disability, Translocation, Karyotype}, volume = {4}, Number = {4}, pages = {13-17}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.4.4.13}, url = {http://jbrms.medilam.ac.ir/article-1-275-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-275-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {HesamiArani, Mohsen and Ghaneian, Mohammad Taghi and Halvani, Gholam Hossain and Dakhilpour, Mahmoud and Delavar, Javad and Rezapour, Habib Allah and DehghaniArani, Monireh and Tazik, Moslem}, title = {Identification of hazardous and risk assessment of energy sources for Kavir Steel Complex using ETBA method in 2015}, abstract ={Introduction: The steel industry is known as the most important consumer of energy and fuel. In doing so, ensuring safety of energy sources of a country needs to expect the risks analysis in order to select a comprehensive approach. This study aimed to identify the energy consumption and control measures available in the Hot Rolling Kavir Steel Complex and to conduct risk assessment by Energy Tracking and Barrier Analysis method (ETBA). Materials and methods: In this study, initially a team of experts identified mobilized energies and risks of the system and control measures using ETBA sheet that result of a standard MILSTD-882B. Then, the initial risk assessment was carried out using ETBA method. Finally, the control strategies were proposed and the secondary risk level was calculated. Results: Using ETBA, in total 19 energy types and 74 risk types were successfully identified so that in the first stage, 19 risks were unacceptable, 50 risks were unfavorable and 5 risks were acceptable for which the corrective strategies were required Then, the corrective revisions were proposed to reduce the risk level and calculate RAC2. Conclusion: Corrective controlling measures including safety, health and environmental training, continual monitoring and ongoing visit are effective using the safety equipment and personal protective equipment for reducing the unacceptable risks.}, Keywords = {Kavir Steel Complex, Energy Trace and Barrier Analysis (ETBA), Risk assessment, Energy}, volume = {4}, Number = {4}, pages = {18-27}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.4.4.18}, url = {http://jbrms.medilam.ac.ir/article-1-280-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-280-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Banparvari, Maryam and Salehikia, Abbas and Azarm, Fateme}, title = {The effect of two types exercise therapy on bone mineral density and mechanical strength of osteoporotic male rats}, abstract ={Introduction: Osteoporosis is a systemic skeletal disease with a consequent increase in bone fracture. The purpose of this study was to determine skeletal changes induced by two types of exercise therapy in osteoporotic rats. Materials and methods: Among 30 male rats, 6 of them were selected as healthy group, Then Osteoporosis induced in other rats by intraperitoneal injection of 20% ethanol solution (3g/kg/day) for 3 weeks. Osteoporotic rats divided into 4 groups: Baseline, resistance, endurance and control (n=6). The two exercise groups completed 12 weeks of training, 5 days/week according to protocols. Endurance protocol included running exercise on a treadmill for, 12 m/min, 10 to 64 min/ day. The Resistance training protocol consisted of 8 series of climbing on the 110cm vertical ladder angled at 80º with weights tied to animal tail that was increased from the 50% of the body mass of the animal in the first series to100% in the eighth series. At the end of the training, the animals were euthanized, and the BMD of the femur and the L4 + L5 vertebrae were measured using DXA and tensile max load of the tibia and compression max load of the L5 were measured applying Zwick 2.5 machine. The collected data was analyzed using paired t and one way ANOVA tests. Results: The two groups of the exercises had significantly increased femur BMD compared to controls (P=0.035, P=0.001). L4+L5 BMD in resistance training and control groups was significantly greater than endurance group (P=0.001, P=0.001). The tibia tensile maximum load and L5 maximum load in resistance group were significantly greater than control (P=0.01, P=0.03). Conclusion: Resistance training induces more effective favorable changes in bone mineral status and bone strength as compared to endurance exercise in osteoporotic male rat.}, Keywords = {Osteoporosis, Exercise therapy, BMD, Bone mechanical strength }, volume = {4}, Number = {4}, pages = {28-35}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.4.4.28}, url = {http://jbrms.medilam.ac.ir/article-1-166-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-166-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {TaheriChadorneshin, Hossein and Neyebi-Far, Shil}, title = {Effect of resistance exercise training on biochemical markers and anthropometric characteristics involved in atherosclerosis in obese women}, abstract ={Introduction: Obese individuals have elevated levels of inflammatory and cell adhesion molecules that can critically induce the occurrence of atherosclerosis. Aerobic exercise training reduces biochemical markers and anthropometric characteristics involved in atherosclerosis. However, little is known about the effect of resistance exercise training on these biomarkers. This study aimed to investigate the effect of eight weeks of resistance training on atherosclerosis biochemical markers and anthropometric characteristics in obese women. Materials and methods: Fourteen obese women completed an 8-week resistance exercise training protocol with moderate intensity at 9 stations (exercise involving the major muscle groups: 3 sets of 8-15 repetitions of chest press, leg press, seated pulley rows, overhead press, seated leg press, leg curl, triceps extensions, biceps curls, and calf raises). Fasting blood samples were taken before and after the 8-week exercise training. Intercellular Adhesion Molecule1 (ICAM-1) and C-reactive protein (CRP) levels were measured using commercial kits by ELISA method. The data were analyzed using dependent t-test. Results: Resistance training significantly reduced the levels of atherosclerosis biochemical markers, ICAM-1and CRP (P=0.001). Also, body fat percentage (P=0.001), waist: hip ratio, body mass and body mass index significantly decreased following resistance training (P=0.001). However, no significant change occurred in platelet counts (P=0.922). Conclusion: Resistance training results in reduction of inflammatory biomarkers involved in atherosclerosis as well as body fat.}, Keywords = {Resistance exercise training, Intercellular adhesion molecule 1, Obese}, volume = {4}, Number = {4}, pages = {36-43}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.4.4.36}, url = {http://jbrms.medilam.ac.ir/article-1-301-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-301-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Kamalvandi, Maedeh and Mohammadfam, Iraj and Farhadi, Rozita and Jalilian, Mohsen and Kurd, Nematullah}, title = {Evaluation of work-related accidents among Hamadan construction workers}, abstract ={Introduction: construction is one of the most important industries in which many workers start on activity. Sometimes, these industries workers are victims of different occupational accidents and injuries. Therefore, the aim of this study was to determine the frequency and underlying reasons in construction accidents. Materials and methods: In this descriptive - analytical study, all construction workers (n = 347) who encountered with occupational accident were studied in Hamadan city, west of Iran. The data were extracted from health profiles of injured workers by checklist. Data were analyzed with SPSS 16 by applying of Chi square and Logistic regression tests at the significant level of P < 0.05. Results: During 2007-2010, 347 workers encountered with construction accidents and seven of them were died. Finding showed that fall and slip were cause of 36.59% of accidents. Also, carelessness was major predictor factor related to 80.96% of accidents. According to the results, 36.02% of these accidents were happened at 15.00 and 18.00 PM. Conclusion: Develop and discussion about organizing public policies is suggested to implement work safety programs for construction workers.}, Keywords = {Accidents, Work-related injuries, Construction workers}, volume = {4}, Number = {4}, pages = {44-49}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.4.4.44}, url = {http://jbrms.medilam.ac.ir/article-1-67-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-67-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} } @article{ author = {Aghamohammadi, Akram and Maghsoodlu, Mahtab and TeimoriNaghadeh, Hosein and Ferdowsi, Shiri}, title = {Iron stores in blood donors: A literature mini review}, abstract ={An increase in the frequency of blood donation among the donor population is liable to result in excessive iron loss and development of iron deficiency anemia. In the majority of blood banks, hemoglobin and/or hematocrit measurements are used as screening tests for the ability to donate blood even though iron stores may be depleted in donors with hemoglobin values above the arbitrarily defined limit for anemia. In the present study, we have reviewed the iron deficiency in blood donors and characteristics which predispose to this condition.}, Keywords = {Blood donors, Iron stores}, volume = {4}, Number = {4}, pages = {50-55}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.4.4.50}, url = {http://jbrms.medilam.ac.ir/article-1-273-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-273-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2017} }