@article{ author = {Barzegari, Amir Abbas and Hashemzaei, Masood and Alihemmati, Ali-Reza and Soltani, Soroush and Naseri, Behrouz}, title = {Effects of Lactobacillus rhamnosus (ATCC 7469) ointment on second-degree burn wound in Wistar rat}, abstract ={Introduction: Burn is among the traumas that impose great physical and psychological damages to the injured people. Scientists still are looking for new treatments and methods for burn management that lack the defects of previous ones. Recently, the potential of probiotic bacteria for the treatment of skin disease and problems has been investigated. Considering that the effects of probiotics are strain-dependent, the aim of current study was to evaluate the effects of Lactobacillus rhamnosus (ATCC 7469) on the process of burn wound healing. Materials and methods: After induction of second-degree burn wounds on the back of rats, they were randomly divided into experimental, vehicle control, and negative control groups. The experimental groups received a bacterial ointment for 1, 3, 7, and 14 days. The vehicle control groups received Eucerin for durations like the experimental groups. The negative control groups received no treatment in the same days. The evaluation of wound healing was conducted macroscopically by computing of the healing percent and microscopically by Hematoxylin and Eosin staining of the tissue samples of the wound area on different days. Results: The wound healing percent in the experimental group, compared with control groups, significantly increased, until the day 7 of the experiments. Moreover, the microscopic results indicate that the bacteria may have some anti-inflammatory effects. Also, the bacteria increased the rate of fibroblastic migration and re-epithelialization in the wound area. Conclusion: Overall, L. rhamnosus (ATCC 7469) when used topically on the burn wounds may have some positive effects on the process of burn wound healing.}, Keywords = {Lactobacillus rhamnosus, Probiotics, Burns, Wound healing, Rats}, volume = {5}, Number = {1}, pages = {1-9}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.1.1}, url = {http://jbrms.medilam.ac.ir/article-1-348-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-348-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Modaresi, Mehrdad and AlasvandZarasvand, Mahnaz and Madani, Mahboobeh}, title = {The effects of hydro-alcoholic extract of Artemisia dracunculus L. (Tarragon) on hematological parameters in mice}, abstract ={Introduction: Artemisia dracunculus L. (Tarragon) is one of the plants that uses as meal and remedy for a long time, and possesses many medicinal properties. In traditional medicine also has mentioned to its beneficial properties. A number of researches through in vitro and in vivo studies showed the pharmacological properties of this plant. This study was done for determining the effect of hydro-alcoholic extract of A. Dracunculus L. on some hematological parameters among mice. Materials and methods: In this study, 40 male mice were divided into five groups: a control, a placebo, and three treatment groups that were injected with 50, 100, and 200 mg/kg doses of hydro-alcoholic extract of tarragon every other day for 20 days. At the end of injections, the levels of WBC, RBC, lymphocytes, monocytes, and neutrophils were measured. Statistical analysis was done using SPSS software and analysis of variance (ANOVA) test. Results: The obtained results showed that there was no significant difference in amounts of WBC, RBC, and monocytes in the treatment groups in comparison with the control group. Lymphocytes showed significant decrease in groups of 100 and 200 mg/kg doses than the control group. The level of neutrophils showed significant increase in two treatment groups (100 and 200 mg/kg) than the control group. Conclusion: It can be concluded that the hydro-alcoholic extract of tarragon stimulates the production of neutrophils in this study which can be used as an immunostimulating agent.}, Keywords = {Artemisia dracunculus L., Blood parameters, Hydroalcoholic, Mice}, volume = {5}, Number = {1}, pages = {10-14}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.1.10}, url = {http://jbrms.medilam.ac.ir/article-1-298-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-298-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Daliri, Salman and Asadollahi, Khairollah and Musavi, Mir Hadi and Karimi, Arezou and Khademi, Gholam Ali and Azizi, Monire and Abangah, Ghob}, title = {The relationship between neonatal factors and involving with glucose-6-phosphate dehydrogenase deficiency (G6PD) and patients\' outcome in Fars Province}, abstract ={Introduction: Glucose-6-phosphate dehydrogenase deficiency (G6PD) or fauvism is the most common enzyme deficiency in human, so that 400 million people are living with this disease worldwide. This study aimed to investigate the role of some neonatal factors among newborns suffering from G6PD deficiency and neonatal outcomes associated with this disease. Materials and methods: In this study, two methods including case-control and retrospective cohort regarding some neonatal factors associated with G6PD deficiency were used. These methods were performed on 142 children with this kind of deficiency and 142 healthy infants in the city of Marvdasht during 2013- 2014. The analysis of data was based on chi-square tests, t-test, logistic regression, descriptive statistics and estimation of odds ratios or relative risks via SPSS16 software. Results: Totally 284 newborns including 132 (46.6%)/ 152 (53.4%) boys/girls and mean weight on birth of 3163 ± 471 (gr) were analyzed. Comparison of case and control samples did not show any significant differences between sex and involving with G6PD deficiency but the chance of having a baby with this defect in pregnancy intervals between 6 to 8 years was increased (95% CI: 1- 4.4, OR: 2). Relative risk of jaundice in infected and healthy infants was estimated as 3.73, which demonstrated a statistically significant association (95% CI: 1.33- 10.4). The frequency of low birth weight, birth order and type of delivery was associated with the disease, but their differences were insignificant compared to the healthy group. Conclusion: The results of this study showed that the number of hospitalization is increased due to jaundice in infants with G6PD. There is also an insignificant relation between low birth weight, rank of birth and type of delivery. Thus, it is recommended that other consequences of this deficiency need to be revealed by screening other populations with more samples.}, Keywords = {Iran, Fars, Favism, Neonate, Newborn, G6PD}, volume = {5}, Number = {1}, pages = {15-21}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.1.15}, url = {http://jbrms.medilam.ac.ir/article-1-289-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-289-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Babaei, Arash and Jafari, Arash and Asadpour, Mohammad and Shamsi, Mortez}, title = {Cucurbita maxima (Pumpkin) seeds: Scolicidal activity and preventive efficacy of its extract on experimental hydatidosis in mice}, abstract ={Introduction: Hydatid Disease (HD), a helminth infection with various clinical complications is a serious economic and public health concern around the world. Nowadays, different agents have been broadly applied as scolicids; these agents have several side effects on patients. Therefore, the aims of this experimental study were to evaluate the scolicidal activity of Cucurbita maxima seeds methanolic extract (ME) against protoscolices of hydatid cyst in-vitro. Also, an in vivo assay was designed to prove the preventive effects of the extract. Materials and methods: For this work, Two different concentrations (25 and 50 mg/ml) of the C. maxima seeds ME were used in various exposure times (10, 20, 30, 40, 50, and 60 min). Additionally, thirty mice were infected intraperitoneally by injection of 1000 viable protoscolices and were divided into three groups with ten mice in each Group I (treated by Albendazole), group II (received 50 mg/ml of C. maxima seeds ME) and group III (untreated controls). Results: Overall, C. maxima seeds ME exhibited significant scolicidal effects in compared with control group (P<0.05). At a concentration of 50 mg/ml, the mortality percentage increased to 84.7%, 96.1% and 100% after 40, 50 and 60 minutes, respectively. Also, the obtain data in necropsy demonstrated that C. maxima seeds ME have an inhibitory effect on the hydatid cyst development. No hydatid cyst formation observed in mice treated with C. maxima seeds ME (50 mg/ml) versus control group which hydatid cyst occurred in 6 (from 10) mice. Conclusion: The current investigation indicated that applying C. maxima seeds ME could be considered as a potential scolicidal agent due to being economical, safer and non-toxic compared to the reference chemical drugs. However, further studies on probably active compounds and also to the determination of its mode of action on parasites are required.}, Keywords = {Hydatid disease, Cucurbita maxima methanolic extracts, Scolicidal, Preventive assay}, volume = {5}, Number = {1}, pages = {22-28}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.1.22}, url = {http://jbrms.medilam.ac.ir/article-1-326-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-326-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {NayebiFar, Shila and TaheriChadorneshin, Hossei}, title = {Aerobic exercise training reduces inflammatory markers involved in atherosclerosis}, abstract ={Introduction: Adipose tissue and inflammatory factors play important role in occurrence of atherosclerosis in overweight women. The present study aimed to investigate the effect of 8 weeks of aerobic exercise training on risk factors involved in atherosclerosis in overweight women. Materials and methods: For this, fourteen overweight women (mean ± standard deviation: body mass index 28.49 ± 3.28 k/m2 and body fat  35.01 ± 3.68%) conducted aerobic exercise training for 8 weeks (at intensity correspond with 65 to 80 % reserved heart rate). Before and after aerobic exercise training, fasting blood samples were taken and anthropometrics characteristics were measured. The data were analyzed using Paired sample t-test (P<0.05). Results: Aerobic exercise training significantly increased maximal oxygen consumption in overweight women (P=0.001). In contrast, aerobic exercise training result in significant reduction in intracellular adhesion molecule 1 levels (P=0.013) and C-reactive protein (P=0.001). In addition, anthropometric measurements of body fat percentage (P=0.006), waist to hip ratio (P=0.01), and body mass index (P=0.001) showed a significant reduction, too. However, no significant change observed in platelet (P=0.127), high density lipoprotein (P=0.107), low density lipoprotein (P=0.095) and cholesterol (P=0.391) levels. Conclusion: Reduction in body fat following aerobic exercise training in overweight women is corresponding with a reduction in inflammatory markers involved in atherosclerosis.}, Keywords = {Aerobic exercise training, Intracellular Adhesion Molecule1, C-reactive protein, Body fat percent}, volume = {5}, Number = {1}, pages = {29-37}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.1.29}, url = {http://jbrms.medilam.ac.ir/article-1-347-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-347-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Yari, Reza and Khodadadi, Iraj and Aliyari, Farshid and Saremi, Zahr}, title = {Influences of combining nano zinc, honey and Aloe vera to accelerate healing the wounds caused by third–degree burn in male balb/c mice}, abstract ={Introduction: Burns are one of the most common household and industrial injuries. There are evidences which demonstrate the therapeutic properties of honey and Aloe vera. We evaluated the topical influences of this material and nano zinc combination on healing the wounds caused by third-degree burns. Materials and methods: 32 balb/c mice divided into a control group (without treatment), group 1 (treated with Aloe vera and nano zinc), group 2 (treated with Aloe vera, honey and nanoz inc) and group 3 (treated with honey and nano zinc). The third-degree burn was created on the back of balb/c mice with general anesthesia observing sterile conditions. Local treatment of burn was conducted once a week during 6 weeks and after the end of treatment, were anesthetized by ether and then killed. After fixation, the practical steps of general histology technique were performed on it. The samples stained with hematoxylin–eosin and they observed with a microscope. Results: We found full tightening of the burn wound and less scar in the group treated with nano zinc and honey compared to control group and other groups. In histological studies, a significant increase was found in the overall thickness of the skin, keratinocyte layer, the epidermis and hypodermis, number and diameter of the hair follicles in a third group versus other groups. Conclusion: The results showed the organic honey and nano zinc combination accelerate the healing process of burn wound in male balb/c mice. While adding Aloe vera to this composition doesn't have an effect on wound healing.    }, Keywords = {Nano zinc, Honey, Aloe vera, balb/c mouse, Burns}, volume = {5}, Number = {1}, pages = {38-46}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.1.38}, url = {http://jbrms.medilam.ac.ir/article-1-314-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-314-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Niroomand, Hassan and Binaafar, Sima and Nasiri, Moein and Mansournia, Nasrin and BagheriBehzad, Atoos}, title = {Sperm abnormalities: Adverse effects of thyroid dysfunction}, abstract ={Introduction: Despite the importance of thyroid hormones in reproduction, there are only a few studies that focus on male infertility. The objective of this study was to evaluate semen parameters in patients with hypothyroidism or hyperthyroidism. Materials and methods: Totally, 28 patients with thyroid disorders were evaluated for the semen parameters. Serum TSH and T4 concentrations were measured by ELISA. Complete semen analyses were performed based on WHO. Results: Pathozoospermia was seen in 32.14% of our patients. Two hyperthyroid patients and seven hypothyroid patients suffered sperm defects. None of pathozoospermia patients showed an alone sperm defects. Sperm multiple anomalies were our main findings. Conclusion: It seems that sperm characterizes strongly were affected. Although, we have a limited sample size, but sperm multiple abnormalities made our interest findings.}, Keywords = {Infertility, Semen, Sperm abnormality, Hypothyroidism, Hyperthyroidism}, volume = {5}, Number = {1}, pages = {47-50}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.1.47}, url = {http://jbrms.medilam.ac.ir/article-1-354-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-354-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Rouhi, Samaneh and Rooshani, Daem and Shakib, Pegah and AhangarKani, Fatemeh and Ramazanzadeh, Rashi}, title = {A 10-year survey on prevalence and occurrence rate of multi-drug resistant Mycobacterium tuberculosis in Latin American and Mediterranean Families: A Systematic review and meta-analysis}, abstract ={Introduction: Latin American and Mediterranean (LAM) is a family of Mycobacterium tuberculosis (M. tuberculosis). Drug resistant in M. tuberculosis LAM family is a major problem in the world population. Our objective of this study was to determine the prevalence of M. tuberculosis LAM family with multi-drug resistant (MDR) in the worldwide by a meta-analysis and systematic review. Materials and methods: Data sources of this study were 68 original articles (2001-2012) which were published in different databases. Research articles with full text in English were selected. Review articles, congress abstracts, studies that were reported in languages other than English and also studies that were not available for us in abstract or full text were excluded. Data that were obtained from prevalence and occurrence rate of MDR M. tuberculosis LAM family were analyzed using meta-analysis random effects models with software package Meta R, Version 2.13 (P < 0.10). Results: During 10 years, lowest rate of prevalence was observed in 2010 and 2006 (95% CI: 5.91%-6.95%) and highest prevalence rate was in 2006 (95% CI: 17.48%- 24.05%). prevalence of MDR- M. tuberculosis analysis showed positive MDR between them (95% CI: 10.30%-11.23%). Prevalence for negative MDR was 9.22% (95% CI: 8.3%- 10.2%). Conclusion: Our study showed that M. tuberculosis LAM family is prevalent in Europian countries. LAM sub lineage was a major focus of studies that carried out in different countries. The proper technique for prevention of transmission of M. tuberculosis is necessary.}, Keywords = {Prevalence, Mycobacterium tuberculosis, Latin American and Mediterranean Family, Multi-Drug Resistant}, volume = {5}, Number = {1}, pages = {51-61}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.1.51}, url = {http://jbrms.medilam.ac.ir/article-1-313-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-313-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Noorimofrad, Saeedreza and Ebrahim, Khosrow}, title = {The effect of high intensity interval training on telomere length and telomerase activity in non-athlete young men}, abstract ={Introduction: Telomeres are DNA portions that are located on the two ends of the chromosome. Telomeres play an important role in cellular life. Exercise is one of the factors that contributes to their control. The purpose of the present study was to investigate the effect of 8 weeks of high intensity interval training (HIIT) on telomere length and telomerase activity in non-athletic young men. Materials and methods: 30 inactive students were selected as sample and randomly divided into two groups of exercise (15 people) and control (15 people) in this semi-experimental study. The exercise group performed 8 weeks of HIIT exercise in 3 sessions per week with an intensity of 150 to 175% of their maximum power (Pmax). Control group subjects did not do regular sport activities. To measure telomere length and telomerase activity, 10 ml of blood was taken from the brachial vein of the subjects 24 hours before the first and after the last exercise session. The dependent t was used to analyze intra-group and independent t for within-group differences. Results: The findings of this study showed that 8 weeks of HIIT training in non-athlete young men resulted in a significant increase in telomere length (P = 0.001) and telomerase activity (P = 0.001). Conclusion: It seems that HIIT can alter telomerase activity and telomere length. Therefore, these training may have a positive effect on cell biology.}, Keywords = {Telomere, Telomerase, High intensity interval training, Non-athlete}, volume = {5}, Number = {2}, pages = {1-7}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.2.1}, url = {http://jbrms.medilam.ac.ir/article-1-361-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-361-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Noorirad, Seyedeh naghme and Pourghasem, Mohsen and Feizi, Farideh and Abedian, Zeinab and Ghasemi, Masoumeh and Babazadeh, Zahra and Rabiee, Navi}, title = {Time dependent of epigenetic effect of disulfiram on tumor suppressor gene of RASSF1A in Hela cancer cell line}, abstract ={Introduction: Cervical cancer is the third most common tumor among women. Surgery, radiotherapy, and chemotherapy are common treatments, however high stage tumors have frequently poor prognosis. Nowadays, the epigenetic reversion introduced as an efficient strategy of treatment of cervical cancer. In the process, inhibitors of DNA methyltransferase (DNMT) induce re-expression of tumor suppressor genes. Among these inhibitors, disulfiram (DSF) has been suggested as non-nucleoside analogous. In this research, we evaluated the epigenetic effect of DSF on demethylation of the tumor suppressor gene, RASSF1A, in Hela cell line. Materials and methods: Hela cells were cultured and treated with different doses from 2.5 to 37.5µM during 24, 48 and 72 hours. MTT assay was carried out to find half maximal inhibitory concentration (IC50). The methylation specific PCR (MSP) assay was applied to evaluate methylation pattern. Results: The IC50 of DSF was determined at the 2.5, 12.5, and 15µM after72 hours. The MSP results showed partial demethylation at mentioned concentrations after 72h but unmethylated band was not observed after 24h. Conclusion: Our findings indicated that, IC50 of DSF exerted a biphasic effect in Hela cell line and at least 72 hours treatment is needed for the epigenetic reversion of DSF on RASSF1Ain Hela cell line.}, Keywords = {Disulfiram, RASSF1A, Epigenetic reversion, Methylation, Cervical cancer}, volume = {5}, Number = {2}, pages = {8-13}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.2.8}, url = {http://jbrms.medilam.ac.ir/article-1-322-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-322-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Mohamadzadeh, Jahansha and Hatefi, Masoud and Roshani, Mina and Dadfar, Reza and Bastami, Hematolah and Asdnahal, Marym and Sohrabnejad, Ali}, title = {An analytical study on behavioral-cerebral system activities and alexithymia among drug abused and none drug abused people}, abstract ={Introduction: One of the common problems in contemporary world is addiction and its side effects. Dependency and addiction due to drug consumption is a chronic disorder which is followed by cultural, psychological, social, and spiritual effects. The aim of the present research was comparing behavioral-cerebral systems with alexithymia among addictive and normal people. Materials and methods: The statistical population was all referred people to therapy centers of addiction in Ilam among which 40 cases were selected by accessible methods and also 40 cases of normal people without addiction background were selected based on their age, gender, education level, and married conditions by homogeneity procedure. Research method was comparative. Questionnaire of characterization by Wilson and questionnaire of Alexithymia by Toronto were used as research instrument to collect the data. Also, SPSS software and multi variable analysis were used to analysis the collected data. Results: The findings showed that activated systems of behavior and fight-flight in people with addiction background  was more than normal people, while behavioral deterrent system activities in normal people was more than people with addiction background (P<0.001).  Also the mean scores of Alexithymia in people with addiction background was significantly more than that of normal people (P>0.001). Conclusion: So, by identifying people that their behavioral activating system is more active than that of normal ones the risky group can be determined and then they can be benefited from behavioral and educational programs to be prevented from the likelihood of addiction in these groups. Also, cultivating capabilities of control and emotion regulation helps to prevent addiction and also helps people to adopt with changes and stress factors.}, Keywords = {Behavioral activation, Fight- flight, Alexithymia, Substance use}, volume = {5}, Number = {2}, pages = {14-20}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.2.14}, url = {http://jbrms.medilam.ac.ir/article-1-327-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-327-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Abdi, Soheil}, title = {Effects of static and electromagnetic fields on human serum paraoxonase-1 activity in vitro}, abstract ={Introduction: In recent years the relationship between electromagnetic fields and coronary artery disease is attracted a considerable attention. Low density lipoprotein (LDL) oxidation is the initial step in the development of atherosclerosis. Paraoxonase1 (PON1) protects LDL and High density lipoprotein (HDL) against oxidative processes, thus preventing the formation of atherogenic (oxidized-LDL) ox-LDL molecules. In this study we investigated the effects of static magnetic fields (SMFs) and extremely low frequency electromagnetic fields (ELF-EMFs) on PON1 activity as one of the independent risk factors for cardiovascular disease. Materials and methods: Pooled serum sample of 20 healthy men were exposed to SMFs and EMFs flux densities of 0.125, 0.25, 0.5, 1, 2, 3 and 4 mT for 60, 120 and 180 minutes at 25°C and then PON1 activity was measured spectrophotometrically using paraoxon as substrate. Results: EMFs of 0.125-1 mT had no effect on PON1 activity. Exposure to magnetic flux density of 2 mT leads to a significant increase in PON1 activity in 1 hour (P <0.05). Magnetic flux density of 3 and 4 mT, after 1hour of exposure, lead to an increase of PON1 activity to 1.2% and 2.8%, respectively (P <0.01). Conclusion: PON1 activity is influenced by a variety of agents like environmental, pharmacological, and lifestyle factors as well as age and sex. According to the finding of this study ELF-EMFs can alternate the serum activity of PON1 in vitro. If this effect of EMFs on PON1 activity has proven in vivo, it can be considered as an effective factor in coronary artery disease.}, Keywords = {Static magnetic field, Extremely low frequency electromagnetic field, Paroxonase-1}, volume = {5}, Number = {2}, pages = {21-26}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.2.21}, url = {http://jbrms.medilam.ac.ir/article-1-295-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-295-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Daramroodi, Aazam Khani and Keshavarzi, Fatemeh and Raissi, Farshi}, title = {The investigation of antibiotic resistance and rapid detection of group B Streptococcus (Bca) from vaginal specimens of pregnant women by colony PCR method}, abstract ={Introduction: Group B Streptococcus (GBS) is one of the most causes of neonatal infections. The bacterium colonizes genitourinary tracts of pregnant women and transmits to infants. The aim of this study was investigating colony PCR and culture methods to detection of GBS in pregnant women. Materials and methods: Hundred pregnant women, at the 35th and 37th weeks of pregnancy, were selected from the Obstetrics and Gynecology Unit of the Moatazedi and Shahid Chamran Hospitals in Kermanshah province. Specimens were collected from vaginal introitus and investigated by selective culture and colony PCR methods. Then, antibiotic resistance tests were performed according to the latest guidelines of Clinical and Laboratory Standards Institute (CLSI). Results: Prevalence of GBS colonization was shown to be 5% and 6% by the culture and colony PCR methods, respectively. Also, resistance rate to erythromycin, penicillin, vancomycin, and the clindamycin were determined to be 50%, 16.66%, 16.66% and 33.33 %, respectively. Moreover, the highest resistance was for erythromycin and the appropriate antibiotics were penicillin and then vancomycin. Conclusion: A higher prevalence of GBS colonization in pregnant women in the Kermanshah city of Iran was detected using colony PCR method compared to culture method.}, Keywords = {Antibiotic Resistance, BCA gene, Colony-PCR, GBS}, volume = {5}, Number = {2}, pages = {27-32}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.2.27}, url = {http://jbrms.medilam.ac.ir/article-1-364-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-364-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Gharibi, Aghdas and Yaghmaei, Parichehr and Basati, Gholam and Soleimannejad, Kourosh and Abbasi, Naser}, title = {Decreased level of the anti-inflammatory adipokines, secreted frizzled-related protein 5 and adiponectin, in high cholesterol diet-induced atherosclerotic rats}, abstract ={Introduction: The involvement of secreted frizzled-related protein5 (SFRP5) and adiponectin, two important adipokines produced by adipocytes, in cardiovascular diseases demand further assessment. Therefore, in this study the relation of the adipokines and atherosclerosis was evaluated in Rat. Materials and methods: For the study, thirty male Wistar rats were divided into 2 groups (each group contain 15 rats): Control group, received a normal diet and the high cholesterol diet (HCD) group which received an additional 2% cholesterol and 0.5% cholic acid for 15 weeks. At the end of treatment, HCD-induced atheroma plaques were observed by hematoxylin and eosin staining of aortic tissue sections. Furthermore, serum levels of SFRP5 and adiponectin in the two groups of rats were measured by immunoassay and their relationships with the development of atherosclerotic plaques in the experimental group were analyzed. Results: The serum level of SFRP5 and adiponectin was significantly decreased in HCD rats compared with the control group (P<0.05).  There was also an inverse relation between the serum level of the two adipokines and atherosclerotic plaque formation (P<0.05).  Conclusion: Serum levels of SFRP5 and adiponectin are decreased in rats fed with high cholesterol diet, highlighting the involvement of the two adipokines in atherosclerosis.}, Keywords = {High cholesterol diet, Atherosclerotic plaque, Adiponectin, SFRP5, Rat}, volume = {5}, Number = {2}, pages = {33-38}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.2.33}, url = {http://jbrms.medilam.ac.ir/article-1-352-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-352-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Raghibdoust, Shahla and Sobati, Elham and Shaghaghi, Vi}, title = {Theory of mind and its neural mechanisms: A case study of Kurdish-Persian congenitally blind children in Ilam city}, abstract ={Introduction: Theory of mind is one of the most important aspects of cognitive faculty. The theory of mind is impaired in individuals who suffer from mental disorders like autistic children. The ‘autistic-like’ behaviors also have been reported in the congenitally blind children. This study was conducted to examine the presence or absence of theory of mind and its function in congenitally blind children. Materials and methods: A number of 20 individuals containing 10 bilingual congenitally blind children from Baghcheban elementary school of Ilam city as a case group and 10 sighted ones as a control group were selected. Three kinds of false belief cognitive tests appropriate for the congenitally blind children were designed. The collected data were analyzed using one sample Kolmogorov–Smirnov test, independent t-test along with Levenn test and one-way and two-way Analysis of Variance. Results: Considering the performance of congenitally blind children in false belief tasks, the blindness just had effect on the story narration task (P<0.05(, while it did not have any effect on the two other tasks. The same performance of the male and female subjects indicated that gender did not have any impact on the development of the theory of mind (P>0.05). Conclusion: The findings showed only the story narration task was affected by blindness, because this task was more dependent on visual sense. Therefore, blindness results in delay in evolution of theory of mind. To fix this delay, the congenitally blind children should be exposed to further tactile and olfactory inputs.}, Keywords = {Congenitally blind, Theory of mind, False belief task, Mirror neurons, Ilam}, volume = {5}, Number = {2}, pages = {39-47}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.2.39}, url = {http://jbrms.medilam.ac.ir/article-1-350-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-350-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {AliMalayeri, Fardin and Rezaei, Aliakbar and Raiesi, Omi}, title = {Antifungal agents: Polyene, azole, antimetabolite, other and future agents}, abstract ={Antifungals have always been considered as one of the astonishing discoveries of the 20th century. This is correct, but the real marvel is the development of antifungal resistance in hospitals, communities, and the environment concomitant with their use. Fungal infections have emerged as an important clinical threat, with significant associated morbidity and mortality.  This study is designed to provide a comprehensive view of antifungal agents and related agents. Information was based on the expertise of some literatures. Over the past decades, the incidence and diversity of fungal infection has grown in association with an increasing number of immunocompromised patients. An understanding of the pharmacokinetic and pharmacodynamics properties of the classes of antifungal compounds is vital for the effective management of invasive fungal infections. This review provides a summary of the pharmacologic principles involved in treatment of fungal diseases.  Clinical needs for novel antifungal agents have altered steadily with the rise and fall of AIDS-related mycoses, and the change in spectrum of fatal disseminated fungal infections that has accompanied change in therapeutic immunosuppressive therapies.}, Keywords = {Antifungal agents, Future agents, Polyenes, Azole }, volume = {5}, Number = {2}, pages = {48-55}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.2.48}, url = {http://jbrms.medilam.ac.ir/article-1-362-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-362-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Ghaderighahfarokhi, Shiva and Sadeghifar, Jamil and Mozafari, Mossayeb}, title = {A model to predict low birth weight infants and affecting factors using data mining techniques}, abstract ={Introduction: Birth weight is a reliable indication of intrauterine growth and determines the child's future physical and intellectual development. The purpose of this study was to use data mining technique in identifying accurate predictors of (low birth weight) LBW. Materials and methods: This study used secondary data from 450 medical records of newborns in the educational Hospitals affiliated to Ilam University of Medical Sciences. The birth records were reviewed from April 2015 to April 2016.  The checklist used to collect data comprised of two parts: demographic and effective factors (13 factors of medical and neonatal, 4 factors of mother's lifestyle and 8 about mother factors). Data were analyzed by SPSS version 21 and WEKA software. Results: Our findings showed that mean weight of infants was 2289 ± 864 gr. The mean gestational age was 35.2 ± 4.63 weeks. 14.9% of mothers suffer from placenta previa and 14.4% suffer from preeclampsia. The results of ANOVA showed that neonatal weight was significantly higher among mothers with weight range of 84-110 Kg. The random forest algorithm showed that gestational age less than 36 weeks is main predictor and number of fetuses, preeclampsia, and premature rupture of membrane, placenta previa, the number of pregnancies and the degree of mother education were other predictors of low birth weight. Conclusion: This study confirmed that low birth weight is a multifactorial condition requiring a systematic and accurate program to reduce LBW. Individual and group education through mass media, repeated monitoring of pregnant mothers, activation of the referral system and pursuit of a family health care technician may reduce prevalence of LBW.}, Keywords = {Low birth weight, Data mining, Gestational age}, volume = {5}, Number = {3}, pages = {1-8}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.3.1}, url = {http://jbrms.medilam.ac.ir/article-1-351-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-351-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Asadollahi, Zahra and Nabian, Sedigheh and Taheri, Mohammad and Ebrahimzadeh, Elahe and Ranjbar, Mohammad Mehdi}, title = {Designing of potential vaccine candidates of fused cathepsin L and tropomyosin genes of Rhipicephalus (Boophilus) annulatus tick larva}, abstract ={Introduction: Regarding emerging tick resistance against acaricides, researches have been shifted toward alternative approaches such as immunologic methods. Vaccine preparation is an alternative way in which choosing appropriate protein with high immune induction potency is a prerequisite. In addition according to studies, using more than one protein could better enhance the immune induction and antibody production. Choosing immunogenic epitopes from selected proteins and adjoining them with a suitable linker is one of the novel approaches in vaccine design. Materials and methods: Based on the fact that both cathepsin and tropomyosin proteins of Rhipicephalus tick were previously recognized as potent immunogenic antigens, we predicted the immunogenic epitopes of these proteins by immunoinformatic methods. Among studied epitopes, those that were met by multiple bioinformatics tools were used. Results: Finally, the polytopic construction was designed by assembling the selected epitopes and connecting them with linkers. Conclusion: Using immunoinformatic tools, we predicted the characteristics of two genes of Rhipicephalus annulatus tick larva as fused potent vaccine candidates namely, cathepsin and tropomyosin.  }, Keywords = {Tropomyosin, Cathepsin, Rhipicephalus annulatus, vaccine design, Iran}, volume = {5}, Number = {3}, pages = {9-16}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.3.9}, url = {http://jbrms.medilam.ac.ir/article-1-359-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-359-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {ShakerianRostami, Sareh and Sohrabnejad, Ali and Mirzaei, Alirez}, title = {Evaluation of thinking style among medical and dental students of Ilam University of Medical Sciences in academic year of 2016-2017}, abstract ={Introduction: Education and research are two thinking based processes. Nowadays, the main function of educational institutions is evaluated by thinking. This study aimed to determine the dominant thinking styles among medical and dental students of Ilam University of Medical Sciences (IUMS). Materials and methods: This cross-sectional study was conducted on all medical and dental students of IUMS in the academic year of 2016-2017. Data was collected by Sternberg’s standard thinking style inventory and a demographic data questionnaire. Data analysis was carried out with the software SPSS 20 using descriptive statistical analysis methods and t-test. Results: In total, 497 students of IUMS participated in the study. Among whom 395 (79.5%) were medicals students and 102 (20.5%) were dental students. The findings showed significant differences between the legislative and executive thinking styles of medical and dental students (P=0.042 and P=0.024 respectively), more specifically, the mean score of legislative thinking style was found to be higher among dental students than that of medical students, and the opposite relation was found in the mean scores  of executive thinking style. Comparison of mean scores of thinking style dimensions between medical and dental students showed significant differences in some but not all dimensions. Conclusion: Considering the differences found in thinking styles of medical and dental students and their effects in emergence of unique behavioral and decision-making characteristics in medical and dental students, educational planners and professors should attempt to adjust their teaching methods and professional approach according to students individual features in terms of thinking style and preferences so as to foster the growth and flourish of their thinking, academic, and clinical capabilities. The results of the study showed significant differences between the legislative and executive thinking styles of medical and dental students, also regarding the different dimensions of thinking styles of medical and dental students, some significant differences in some but not all dimensions were reported.}, Keywords = {Thinking, Thinking style, Medical and dental students}, volume = {5}, Number = {3}, pages = {17-22}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.3.17}, url = {http://jbrms.medilam.ac.ir/article-1-320-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-320-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Azimzadeh, Kaveh and Jafarpour, Hossein and Digeleh, Farid and Gargarechi, Armi}, title = {Oral administration of triethylenetetramine (TETA) reduces some inflammatory markers in streptozotocin-induced diabetes mellitus in rat}, abstract ={Introduction: Owing to harmful effects of inflammatory markers on occurrence and progression of diabetic complications, hence, studying the possible effect of chemical components on these markers seems to be effective in diabetes mellitus. This study aimed to assess whether the triethylenetetramine (TETA), as a copper chelator, affects the plasma level of inflammatory markers such as visfatin (Vis), cholinesterase (CholE), total sialic acid (TSA) and hepcidin (Hep) in streptozotocin- induced diabetes mellitus rat. Materials and methods: Thirty male Wistar rats were assigned for this study. After induction of diabetes mellitus, TETA with different doses (10, 20 and 40 mg/kg/day) was orally administrated for 6 months. Thereupon, the above inflammatory factors were measured in all treatment groups. Results: Plasma concentrations of Vis, CholE, TSA, Hep and glucose decreased significantly (P<0.01) in the highest dose group (40 mg/kg/day) compared with control group. Interestingly, by enhancement of TETA dose, these levels were lowered. Conclusion: The results suggested that TETA administration in the dose of 40 mg/kg/day leads to profound reduction of the inflammatory markers Vis, CholE, TSA and Hep, therefore may have beneficial effect on diabetes mellitus.}, Keywords = {Triethylenetetramine, Diabetes mellitus, Novel inflammatory markers}, volume = {5}, Number = {3}, pages = {23-31}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.3.23}, url = {http://jbrms.medilam.ac.ir/article-1-355-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-355-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Mahmoudi, Ghahraman and AbdiTalarposhti, Masoomeh}, title = {An assessment of agility in selected hospitals of Mazandaran province, Iran}, abstract ={Introduction: Evaluating agility effectively and efficiently is necessary and challenging for organizations. Therefore, this article aimed to assess the performance of hospitals with organizational agility (OA) approach. Materials and methods: A descriptive-analytical study was done in which the statistical population consisted of managers and experts of hospital courses including medicine, nursing, midwifery, and paramedics. A total of 283 managers and experts were enrolled as the sample using the Krejcie and Morgan table with stratified random sampling. Data were analyzed using one-sample t test with SPSS20. Results: Among 13 elements of agility, the results showed that competence (P=0.032) had a significant difference with customer satisfaction (P=0.029). The results also showed that OA was not optimal in selected hospitals of Mazandaran province, Iran. Concerning the indicators, introduction of new product (8.56) and staff skill development indicator (5.32) were maximum and minimum, respectively. Conclusion: The results showed that OA was not optimal in selected hospitals. Introduction of new product scored the top, while staff skill development was the lowest. As a result, health policy makers are recommended to plan for customer satisfaction, timely utilization of facilities, elimination of weak points, lost cost reduction, encouragement and punishment system for staff, and staff empowerment.}, Keywords = {Organizational agility, Accountability, Competence, Flexibility, Speed, Hospital}, volume = {5}, Number = {3}, pages = {32-41}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.3.32}, url = {http://jbrms.medilam.ac.ir/article-1-319-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-319-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Naghibzadeh, Maryam and Ranjbar, Rouhollah and Tabandeh, Mohammad Reza and Habibi, Abdolhamid and Ghotbeddin, Zohreh}, title = {Comparison of high-intensity interval versus low-intensity continuous training for myelin synthesis related genes in C57BL/6 mice}, abstract ={Abstract  Introduction: By increasing the scientific focus on myelination, identifying factors that influence the myelination is an important goal for brain health. There are some studies that regular exercise improves myelin sheath and neuronal regeneration. However, the effects of exercise intensities on the myelination remain unclear. Therefore, the purpose of this study was to compare the effect of high-intensity interval (HIIT) versus low-intensity continuous training (LICT) on myelin synthesis-related genes in hippocampus of C57BL/6 mice. Materials and methods: Male C57BL/6 mice (n = 30) were randomly assigned to 3 groups: control (C), Interval training (IT), and Continuous training (CT). Training programs on the treadmill were performed for 8 weeks and then, the hippocampus of animals was analyzed for the expression of myelin basic protein (MBP) and proteolipid protein (PLP) genes. Data were analyzed using ANOVA. Results: The result showed that HIIT program significantly increased the mRNA levels of MBP and PLP in comparison with LICT and Control groups (P<0.05), while no significant differences were observed among the LICT and Control groups (P>0.05). Conclusion: Our results showed that HIIT had a more efficient by improving the expression of MBP and PLP genes compared to LICT in the hippocampus.}, Keywords = {Interval training, Continuous training, Myelin basic protein, Proteolipid protein, Hippocampus}, volume = {5}, Number = {3}, pages = {42-48}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.3.42}, url = {http://jbrms.medilam.ac.ir/article-1-368-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-368-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Ghafari, Ramin and JalayerNaderi, Noushin and EmamiRazavi, Amirnader}, title = {Age related changes in clinicopathologic features of oral squamous cell carcinoma (OSCC) in Iranian patients: An epidemiologic study}, abstract ={Introduction: Clinicopathologic characteristics of oral Squamous cell carcinoma (OSCC) affected by age, although it is controversial. In this study the differences in clinicopathological features of OSCC were compared between patients younger and older than 40 years' old. Materials and methods: In this retrospective study the histopathologic records of OSCC patients who underwent surgery in Cancer Institute of Iran during 2005-2015 were retrieved. The demographic and histopathologic features of patients in two groups of younger than 40 and older than 40 years old were recorded and descriptive analysis was used for statistical interpretation between groups. Results: The most cases of OSCC in both groups was registered in males with 14.3% and 85.7% of cases in younger and older than 40, retrospectively. Tongue was the most prevalent anatomic location of OSCC in both groups (39%). Based on clinicopathologic features, most prevalent pathologic degree of OSCC in younger aged patients was moderately differentiated OSCC (14.5%). In patients older than 40, well differentiated OSCC (87.7%) was more prevalent. Conclusion: Based on histopathologic features, the moderately differentiated and well differentiated OSCC were more in younger and older patients than 40, respectively. The finding suggests that OSCC has more malignant feature in young patients.}, Keywords = {Squamous cell carcinoma, Oral cavity, Prognosis}, volume = {5}, Number = {3}, pages = {49-51}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.3.49}, url = {http://jbrms.medilam.ac.ir/article-1-376-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-376-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Mahdavi, Manijeh and Fallah, Zahra and Kelishadi, Roy}, title = {Expression of Toll-Like receptors in metabolic syndrome: A systematic review}, abstract ={Introduction: Toll-Like Receptors (TLRs) of innate immune system have documented roles in the pathogenesis of metabolic disorders. This study aims to systematically review the expression of TLRs on metabolic syndrome (MetS). Materials and methods: We systematically searched PubMed/Medline, ISI web of Science, Scopus, Google Scholar, EMBASE, and OVID databases until February 2017. The terms ‘‘Metabolic Syndrome’’ OR ‘‘Mets’’ AND ‘‘Toll like receptor’’ OR ‘‘Toll like’’ OR ‘‘TLRs’’ OR ‘‘TLR’’ were used. “Expression” advertently was not used in our search and was considered in the selection process. Three steps for selecting the articles and then their qualification were conducted. Results: First, 1373 articles were found in the international databases. After removing duplicates, 963 papers remained and after two steps of selection, this number reached 410 and then 27, respectively. After full text screening and qualifying processes, we finally included 13 articles consisting of five animal and eight human studies. All human studies reported overexpression of TLRs (types 2, 4, 5, 9) in MetS, and most animal studies documented an increased TLRs expression. Conclusion: This systematic review provides evidence for the relation of innate immune system with MetS. Its findings regarding overexpression of special TLRs (e.g. types 2, 4, 5, 9) in MetS and their basic mechanisms and clinical implications might be investigated in further studies.}, Keywords = {Metabolic Syndrome, Toll-Like Receptors, Chronic disease, Inflammation}, volume = {5}, Number = {3}, pages = {52-56}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.3.52}, url = {http://jbrms.medilam.ac.ir/article-1-363-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-363-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Niroomand, Hassan and Binaafar, Sima and Shayegan, Amir Ehsan and Varyani, Mohsen and Rezakhaniha, Bij}, title = {Ureteral stone extraction under direct ureteroscopic vision: An alternative for routine ureteral stone management}, abstract ={Introduction: During recent years, considerable efforts have been expended into the management of urinary stone. Here, we present our experience on ureteric stone removal without any lithotripsy interventions. Combination direct vision with basket en-trapping provided a new dimension to our ureteroscope experience. Materials and methods: Here, we reviewed the medical data of our adult patients with ≤10 mm stone size, who received primary stone extraction under direct ureteroscopic vision without lithotripsy during a 2-year period. During the six months of follow-up every patient was seen frequently. Results: The study included 69 patients from both sexes with ages ranging from 18 to 68 years. We obtained 92.7% success rate. The average length of operative procedures was 25.3 ± 10.4 min with a 14.4 % complication rate. Conclusion: Ureteral stone extraction requires considerable caution and may be associated with some complications. Stone extraction under direct ureteroscope guidance facilitates this procedure, especially in the distal stones. It seems combination direct live imaging with basket en-trapping may be helpful in these precise cases.}, Keywords = {Urinary stone, Direct vision, Ureteroscopy, Basket en-trapping, Adult}, volume = {5}, Number = {4}, pages = {1-5}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.4.1}, url = {http://jbrms.medilam.ac.ir/article-1-374-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-374-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {SofiMaryo, Leila Sofi Maryo and Haghnazari, Nahid and Keshavarzi, Fatemeh and Zhaleh, Hassan and Seidi, Farz}, title = {Synthesis of poly (amidoamine) (PAMAM) dendrimer-based chitosan for targeted drug delivery and cell therapy}, abstract ={Introduction: In the current study we designed a sophisticated drug delivery nanoparticle to control the methylprednisolone succinate delivery rate and affect the cancer cell growth in culture condition. Materials and methods: Magnetic nanoparticles were synthesized through co-precipitation method. Fe3O4 was first prepared via co-precipitation method and then its surface was functionalized with polyamidoamine (PAMAM) nanodendrimer. PAMAM synthesis trait was detected via FT-IR and SEM methods. Methylprednisolone drug was loaded on PAMAM@Fe3O4 and its effect against cancer cell lines was studied. In order to slow down drug release rate from nanoparticles, PAMAM@Fe3O4 were coated with trimethylchitosan (TMC) after drug loading.  Performance of PAMAM@Fe3O4@TMC nanoparticles loaded with mmethylprednisolone, were evaluated against two cell lines to detect the cytotoxic and apoptotic effects by invert light scanning microscopy, immunoassay, and LDH cytotoxicity Kit. Results: According to SEM, image size of Fe3O4 was 4.79-6.37nm, which is smaller than nanodendrimer (6.30-43.67 nm). FT-IR spectrum for ester bond Methylacrylate @ Ethylendiamin was obtained to be 1720-1730 cm-1. FT-IR Spectrums 600 cm-1, 1000 cm-1 belong to Fe3O4, and Fe3O4@ NH2. Also, trimethyl chitosan coated Nanoparticle @ Drug, smearing trimethyl chitosan with Glutaraldehyde, created cross link between TMC monomer at low drug doses in each complete nanoparticle, gave confidence drug side effect, therefore, this nanoparticle could be safe for future cancer therapy. Conclusion: The results showed that drug delivery via PAMAM@Fe3O4 nanoparticle reduces cell viability in vitro condition. }, Keywords = {PAMAM dendrimer, Fe3O4, Trimethylchitosan, Cytotoxicity, Magnetic, Drug delivery}, volume = {5}, Number = {4}, pages = {6-13}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.4.6}, url = {http://jbrms.medilam.ac.ir/article-1-381-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-381-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Dovodizadeh, Zohreh and Rouhi, Leila and Azizi, Shahrz}, title = {Therapeutic effects of aerial parts of Smyrnium cordifolium ethanolic extract on ethylene glycol-induced kidney calculi in rats}, abstract ={Introduction: In this study, the effects of the ethanolic extract of aerial parts (stem and leaves) of Smyrnium cordifolium (S. cordifolium) Boiss on the ethylene glycol(EG)-induced kidney calculi in rats was investigated. Materials and methods: Thirty-six male Wistar albino rats were randomly divided in 6 groups. Group I (normal control), Groups II (control of EG) to VI received EG 1% v/v in water for 28 days. Animals in Groups III and IV (preventive groups) received ethanolic extract of stem and leaves of S. cordifolium in 200 mg/kg and 400 mg/kg orally in water for 28 days, respectively. Groups V and VI (treatment groups) received extract in 200 mg/kg and 400 mg/kg orally in water from 15th to 28th day, respectively. Results: Results showed that the level of urine oxalate, blood urea and creatinine in EG group vs. normal control significantly increased (P<0.001). Extract did not show significant effect on urinary oxalate, urine volume and other blood biochemical parameters in the treatment groups (V and VI). Provision of extract resulted in significantly lower levels of urine oxalate and higher level of volume, serum creatinine and blood urea in III and IV groups as compared with Group II (P<0.05). Conclusion: These observations enable us to conclude that the ethanolic extract of aerial parts of S. cordifolium Boiss is effective against EG induced urinary calculi in rats.}, Keywords = {Kidney stone, Ethyl glycol-induced kidney calculi, Smyrnium cordifolium Boiss}, volume = {5}, Number = {4}, pages = {14-21}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.4.14}, url = {http://jbrms.medilam.ac.ir/article-1-269-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-269-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Abdal, Khadijeh and Mostafazadeh, Samira and Darvishi, Marziyeh}, title = {The frequency of tumors of the head and neck in a 10-year period in Ilam, Iran}, abstract ={Introduction: Cancer is one of the five leading causes of death around the world, and head and neck cancer is one of the most common incidences, leading to the death of thousands of people each year. Given the epidemiological importance of head and neck cancers, this study aimed to examine the prevalence of head and neck cancers over a 10-year period in Ilam. Materials and methods: This descriptive study was done using the files of 1106 patients with head and neck lesions who were referred to Imam Khomeini hospital in Ilam in a 10-year period between 2004 and 2015. All the data in the files, including age, sex, type and location of the lesion, was recorded, evaluated, and analyzed using independent t-tests and chi-square statistical methods with SPSS 19. Results: The annual incidence of head and neck cancers in Ilam was estimated at 1.5 per 100,000 people. Basal cell carcinoma was the most common cancer of the head and neck (18.50%). The most common site of squamous cell carcinoma occurrence was the tongue at 54%. Regarding sex, 55.5% of patients were male and 44.5% were female. Regarding malignancy, 289 lesions (26.13%) were reported as malignant and 817 lesions (73.86%) were reported as benign. Conclusion: Considering the high incidence of basal cell carcinoma and squamous cell carcinoma the importance of early diagnosis of these cancers and their treatment requires appropriate planning to improve survival of these patients and to reduce the disease’s complications.}, Keywords = {Cancer, Basal cell carcinoma, Squamous cell carcinoma}, volume = {5}, Number = {4}, pages = {22-27}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.4.22}, url = {http://jbrms.medilam.ac.ir/article-1-358-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-358-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Ahmadi, Saeid and Varvaei, Akbar and Kazemi, Ghob}, title = {Investigating the factors and methods of suicide in Ilam province (from 2012 to 2016)}, abstract ={Introduction: The phenomenon of suicide has been considered by experts of social sciences and psychology. Considering the issue of suicide, a precise analysis must first be carried out in a specific geographic region. Secondly, the cultural coordinates of the climate should be taken into account. The purpose of this study was to investigate the factors and methods of suicide in Ilam province. Materials and methods: The statistical population of this research included all suicide cases committed in Ilam province from 2012 to 2016. The total sample size based on the recorded cases from 2012 to 2016 was 3078 cases. Data analysis of this research was done at two levels of descriptive and responding to research questions. At the descriptive level, indicators such as frequency, percentage, cross-tables, and frequency distribution charts were used. In the answer section of the research Kruskal Wallis and Xi-Du were used.   Results: There was a significant difference between the frequency of successful and unsuccessful suicides. 10.92% of suicides were successful and 89.08% were unsuccessful. Men tended to suicide more than women, but this was not statistically significant. In some age groups, suicide rates were higher than other groups, 34.7% were suicidal in the 21 to 25 age group, 30.06% in the age group of 31 and older, and 34.24% in the remaining age groups. Considering the methods, 73% of suicides have used pills over the last five years, and there was a significant relationship between the motivation of individuals and their tendency towards suicide (48.4%). Conclusion: The results of this study revealed that in committing suicide the individual, social, and psychological factors play the main roles, the results also presented the rate of being successful or unsuccessful in committing suicides, the gender of these attempters, their age range, the education level, the manner of committing, and finally their motive to commit suicide in years of 2012 to 2016.}, Keywords = {Suicide, Ilam province, Causes of suicide, Suicide practices}, volume = {5}, Number = {4}, pages = {28-34}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.4.28}, url = {http://jbrms.medilam.ac.ir/article-1-343-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-343-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Abdi, Safoura and Basati, Gholam}, title = {Association of low serum level of secreted frizzled-related protein 5 (SFRP5) with the presence and severity of coronary artery disease}, abstract ={Introduction: Secreted frizzled-related protein 5 (SFRP5), an anti-inflammatory adipokine, is excreted by adipose tissue and may have protective effects on cardiovascular system. In the present study, the relationships of serum level of SFRP5 with the presence and severity of coronary artery disease (CAD) was investigated.   Materials and methods: In the current study, 40 control subjects, 40 stable and 40 unstable CAD patients were included. Serum level of SFRP5 in all subjects in the study was determined by immunoassay method. The severity of CAD (based on Gensini score) was assigned by angiography examination. The status of conventional risk factors was also determined. Then, the association of SFRP5 with CAD severity and traditional CAD risk factors was explored. Results: Serum level of SFRP5 was lowest in unstable CAD, followed by stable CAD patients and then control subjects (P < 0.001). The correlation of SFRP5 with Gensini score was significant only in unstable CAD patients (P < 0.01). However, the correlation of SFRP5 with the traditional CAD risk factors was relatively significant and negative in all patients (P<0.05). SFRP5 had a reverse association with the presence of CAD. Conclusions: Decreased level of serum SFRP5 is associated with the presence and severity of CAD, highlighting its usefulness as a potential clinical biomarker.}, Keywords = {SFRP5, Unstable CAD, Coronary artery diseases}, volume = {5}, Number = {4}, pages = {35-40}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.4.35}, url = {http://jbrms.medilam.ac.ir/article-1-370-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-370-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Batavani, Mohammad Reza and Marandi, Sayyed Mohammad and Ghaedi, Kamran and Esfarjani, Fahime}, title = {Lack of association between insulin-like growth factor-I (IGF-I) gene polymorphism (rs35767) and power performance in professional, amateur athletes and non-athlete individuals in Iranian population}, abstract ={Introduction: Genetic variation between individuals may include single nucleotide polymorphisms. These individual differences could change human phenotypes (such as skeletal structure, heart and lung size). Insulin-like growth factor-I (IGF-I) is a critical factor in growth and exercise-associated muscle development. In this study we analyzed the frequency of IGF-I rs35767 polymorphism in karate-Kas athletes to find whether there is a difference among professional, amateur athletes and non- Karate-Kas.   Materials and methods: Two hundred and fifty-four athletes (95 professional Karate-Kas, and 159 amateur Karate-Kas) and 159 non-athletic healthy individuals participated in the current study. Following provision of informed consent, 2 mL of blood samples were taken. After DNA isolation, the genotyping frequencies of the IGF-I gene C/T polymorphism was assessed by restriction fragment length polymorphism (RFLP) analysis. Statistical analyses carried out using SPSS software (version 20) and data with P<0.05 were considered to be significant. Results: Frequency of T/T and C/T genotypes in comparison to C/C genotype was increased in professional Karate-Kas and amateur Karate-Kas versus to control volunteer (odd ratio > 1) however, was not significant. Odd ratios of T/T and T/C genotypes compared to C/C in professional group versus controls were 1.125 (95%CI: 0.556 - 2.275) and 1.034 (0.538 - 1.984), respectively. Also, odd ratio of T/T and T/C in amateur group versus controls were 1.002 (0.535 - 1.876) and 1.256 (0.715 - 2.205), respectively. Conclusion: The IGF-I gene C/T polymorphism is not significantly associated with the physical performance´s levels of karate-kas athletes in Iranian population.}, Keywords = {IGF-I, Polymorphism, Professional Karate-Kas, Amateur Karate-Kas}, volume = {5}, Number = {4}, pages = {41-46}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.4.41}, url = {http://jbrms.medilam.ac.ir/article-1-394-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-394-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} } @article{ author = {Raiesi, Omid and Shabandoust, Hajar and Dehghan, Parvin and Shamsaei, Sina and Soleimani, Ameneh}, title = {Fungal infection in foot diabetic patients}, abstract ={Diabetic patients are more susceptible to cutaneous fungal infections. Cutaneous lesions and Foot infections are a frequent complication of patients with diabetes mellitus, accounting for up to 20% of diabetes-related hospital admissions. Foot ulcers and other foot problems are a major cause of morbidity and mortality in people with Diabetes mellitus. The higher blood sugar levels cause increasing the cutaneous fungal infections in these patients. More than 75% of diabetes mellitus (DM) patients are at risk for diabetic ulcers. About 15% of foot ulcers in diabetic patients lead to amputations. Although every 30 seconds one leg is amputated in the world due to DM, 80% of these cases are preventable. Poor controlled had significantly higher fungal infection in diabetic foot ulcers and require careful attention and management. The findings of various studies indicate that the prevalence of fungal infections in patients with diabetic foot ulcers is increasing and there are many drug resistance issues reported in this area, therefore more attention is important in diabetic centers about this neglected issue.}, Keywords = {Diabetic foot ulcer, Fungal infections, Diabetes mellitus (DM)}, volume = {5}, Number = {4}, pages = {47-51}, publisher = {ilam university of medical sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, doi = {10.29252/jbrms.5.4.47}, url = {http://jbrms.medilam.ac.ir/article-1-365-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-365-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2018} }