@article{ author = {KhabbazKababi, Mohammad Hossein and Rezaeian, Najmeh and NegahbanSioki, Hossein and Y'aghoubi, Ali}, title = {Effect of Resistance Training along with Electrical Muscle Stimulation on Serum Levels of Some of the Molecular Markers of Muscle Hypertrophy in Male Athletes after Anterior Cruciate Ligament Surgery}, abstract ={Introduction: To the best of our knowledge, no study has been evaluated the effect of a combination of resistance training and electrical muscle stimulation (EMS) on muscle hypertrophy factors in injured athletes. The aim of this study was to investigate the effect of EMS on serum levels of some molecular markers of muscle hypertrophy in male athletes after anterior cruciate ligament surgery (ACL). Materials and Methods: Twenty male athletes after ACL surgery were selected and randomly divided into two groups: EMS and control (10 subjects in each group) of. Subjects in both groups performed resistance training (at intensity of 30-70 percentage of 10-repetition maximum, 2-4 sets). Whereas, subjects in EMS group performed resistance training with EMS at frequency of 35-70 Hz. Blood samples were collected before and 48 hours after the last training session to measure serum levels of sirtoin-1 (SIRT1), visfatin and nitric oxide (NO). Results: The finding showed that 12 weeks of EMS significantly increased serum levels of SIRT1 (P < 0.001), visfatin (P = 0.02) and NO (P = 0.01) in post-test compared to the pre-test. The results also revealed that the EMS training significantly increased SIRT1 (P < 0.001) and NO (P = 0.021) levels in comparison with the control group. However, there was no significant difference between two groups in visfatin levels (P > 0.05). Conclusion: The results suggest that EMS training could possibly be a good alternative to the traditional resistance training to stimulate factors related to muscle protein synthesis.}, Keywords = {Electrical muscle stimulation, Visfatin, Nitric oxide, Anterior cruciate ligament injury}, volume = {9}, Number = {1}, pages = {1-9}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-549-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-549-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Parastesh, Mohammad and Bayatiani, Mohammadreza and Khaleghi, Mina and SadeghianShahi, Mohammadreza and AyatizadehTafti, Farahnaz and Aria, Behz}, title = {The effect of high-intensity interval training on inflammatory markers in male rats undergoing X-ray radiation}, abstract ={Introduction: One of the famous cancer treatments that are associated with an increment in inflammatory factors is X-ray radiation. This study aimed to evaluate the effect of high-intensity interval training on inflammatory markers in male rats undergoing X-ray radiation. Materials and Methods: In this experimental study, 24 male rats were randomly divided into 4 groups: healthy control (n=6), HIIT (n=6), X-ray radiation (n=6) and X-ray radiation + HIIT (n=6). first, X-ray radiation and HIIT + X-ray radiation groups were anesthetized with ketamine xylazine solution (K, 60-90 kg/mg; Z, 6-10 kg/mg) and then placed on a 1 cm thick Plexiglas plate. The X-ray radiation photon beam was performed using X-ray with 4 Gy linear accelerators (Elekta Compact 6-MV China). The training program included ten weeks of HIIT. Serum levels of Tumor Necrosis Factor Alpha (TNF-α) and Interleukin-6 (IL-6) were measured by rat ELISA Kits. One-way ANOVA was used to determine the existence of a significant difference among groups. Results: The results showed a significant difference between TNF-α and IL-6 in the HIIT, X-ray radiation, and HIIT + X-ray radiation groups with the control group (P < 0.05), but there was no significant difference between these three groups (P > 0.05). Conclusion: X-ray radiation can increase TNF-α and IL-6. HIIT, on the other hand, can also enhance these factors. It seems better for people undergoing radiotherapy to use another exercise training instead of HIIT. }, Keywords = {X-ray radiation, High-intensity interval training, TNF-α, IL-6}, volume = {9}, Number = {1}, pages = {10-18}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-639-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-639-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Sayevand, Zahra and Nazen, Farzad and Nazari, Afshi}, title = {Preconditioning by the exercise and curcumin protects left ventricular myocardium against ischemia-reperfusion injury and suppresses ventricular arrhythmias in rats}, abstract ={Introduction: The present study examined the effects of a 10-week preconditioning with moderate-intensity aerobic exercise and curcumin supplementation before ischemia-reperfusion (IR) to investigate if this method contributes to the protection of cardiac myocardium against IR-induced injury and left ventricular dysfunction in rat. Materials and Methods: Male Wistar rats (6-8 weeks old) were randomly assigned to the 5 groups (each with 10 rats), sedentary-control (Sed-CON), sedentary ischemia-reperfusion (Sed-IR), exercise with IR (Ex-IR), curcumin with IR (Cu-IR), and both exercise and curcumin with IR (Ex-Cu-IR). Exercise intervention performed five times a week for 10 weeks. After the training period, arrhythmias and electrocardiogram parameters, factors involved in cardiac structure and function, and infarct size of myocardium were investigated. Results: We observed that a 10-week moderate-intensity aerobic exercise (15-45 min at 12-24 m/min) five sessions a week as well as curcumin supplementation (50 mg/kg) over the mentioned period, in advance to IR, significantly decreased IR-induced infarct size in Ex-IR, Cu-IR, and Ex-Cu-IR groups compared to Sed-IR (P = 0.0001), alleviated arrhythmia by reduction in ventricular ectopic beats episodes in Ex-IR, Cu-IR, and Ex-Cu-IR groups compared to Sed-IR (P = 0.001), decreased ventricular tachycardia episods in Ex-IR, Cu-IR, and Ex-Cu-IR groups in comparison to that of Sed-IR group (P = 0.001) and improved cardiac function (P = 0.001). Conclusion: According to our findings, exercise has superior cardioprotective effects than curcumin. The combination of curcumin and exercise has no preference on exercise or curcumin alone. Hence both long-term aerobic exercise and curcumin supplementation are effective cardioprotectors against IR-induced injury. Introduction: The present study examined the effects of a 10-week preconditioning with moderate-intensity aerobic exercise and curcumin supplementation before ischemia-reperfusion (IR) to investigate if this method contributes to the protection of cardiac myocardium against IR-induced injury and left ventricular dysfunction in rat. Materials and Methods: Male Wistar rats (6-8 weeks old) were randomly assigned to the 5 groups (each with 10 rats), sedentary-control (Sed-CON), sedentary ischemia-reperfusion (Sed-IR), exercise with IR (Ex-IR), curcumin with IR (Cu-IR), and both exercise and curcumin with IR (Ex-Cu-IR). Exercise intervention performed five times a week for 10 weeks. After the training period, arrhythmias and electrocardiogram parameters, factors involved in cardiac structure and function, and infarct size of myocardium were investigated. Results: We observed that a 10-week moderate-intensity aerobic exercise (15-45 min at 12-24 m/min) five sessions a week as well as curcumin supplementation (50 mg/kg) over the mentioned period, in advance to IR, significantly decreased IR-induced infarct size in Ex-IR, Cu-IR, and Ex-Cu-IR groups compared to Sed-IR (P = 0.0001), alleviated arrhythmia by reduction in ventricular ectopic beats episodes in Ex-IR, Cu-IR, and Ex-Cu-IR groups compared to Sed-IR (P = 0.001), decreased ventricular tachycardia episods in Ex-IR, Cu-IR, and Ex-Cu-IR groups in comparison to that of Sed-IR group (P = 0.001) and improved cardiac function (P = 0.001). Conclusion: According to our findings, exercise has superior cardioprotective effects than curcumin. The combination of curcumin and exercise has no preference on exercise or curcumin alone. Hence both long-term aerobic exercise and curcumin supplementation are effective cardioprotectors against IR-induced injury.}, Keywords = {Antiarrhythmic herbs, Cardioprotection, Moderate-intensity exercise, Reoxygenation injury, Cardiovascular disease}, volume = {9}, Number = {1}, pages = {19-30}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-608-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-608-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Taheri, Ali and Javidi, Hojatollah and Bagholi, Hossein and Firoozabadi, Ali}, title = {The Mediating Role of Cognitive Emotion Regulation and Cognitive Distortion Strategies in Relation to Attachment Styles and Dissociative Experiences}, abstract ={Introduction: In dissociative experience, the coherent and perfectly coordinated quality of human cognition becomes highly incoherent. This study aims at investigating the mediating role of cognitive emotion regulation and cognitive distortion strategies between attachment styles and dissociative experiences among students. Materials and Methods: This study was descriptive and used a correlation design. The statistical population consisted of all students of Islamic Azad University of Marvdasht. Using convenience sampling, 329 students (187 girls and 142 boys) were selected as the sample of the study. For accomplishing the research, the dissociative experiences (Bernstein and Putnam, 1986), attachment styles (Bartolomio and Horowit, 1991), cognitive distortion (Hammachi and Ozturk, 2004), and emotion regulation (Garnefski, Kraaij, Spinhoven, 2001) questionnaires, were used. Results: The results showed that the direct effect of safe style, isolation avoidance, and fearful style on dissociative experiences was equal to -0.15, 0.17, 0.21 which was significant (P < 0.01). The direct effect of preoccupied style was not significant. The indirect effect of safe and fearful style on dissociative experiences were equal to -0.12 and 0.33 which was significant (P < 0.01 and P < 0.05, respectively). The indirect effect of avoidance/detachment style and preoccupation style was not significant. The fitness of the model was 0.02, which was at the desired level.   Conclusion: Considering the negative effect of secure style and the positive effect of insecure style on dissociative experiences, the importance of secure style and insecure style should be given more attention in treatment.}, Keywords = {Dissociative experiences, Attachment styles, Cognitive distortion, Emotion regulation}, volume = {9}, Number = {1}, pages = {31-39}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-605-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-605-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Yaghoubian, Azadeh and Peeri, Maghsoud and Azarbayjani, Mohammad Ali}, title = {Different intensity circuit resistance training effect on the plasma level of the inflammatory cytokines, IL-6 and TNF-α in postmenopausal women}, abstract ={Introduction: Obesity related inflammation plays an important role in the pathogenesis of insulin resistance and type 2 diabetes. In contrast, exercise training can decrease insulin resistance by modulating inflammation. The aim of present study was to investigate the effect of 12 weeks different intensity circuit resistance training on the levels of the inflammatory mediators, IL-6 and TNF-α in obese postmenopausal women. Materials and Methods: In the study, 44 postmenopausal women with average age of 56.07 ± 3.18 years old were selected and randomly assigned in four group including the control, low (L-RT), moderate (M-RT) and high intensity circuit resistance training (H-RT) groups. Circuit resistance training for L-RT, M-RT and H-RT groups, respectively, was conducted with 40, 60 and 80 percent of one repetition maximum. Blood sampling prepared in the pre and post-test stages and the plasma levels of TNF-α and IL-6 were measured by an immunoassay method. Results: There was no significant difference between the groups under study for TNF-α levels (P = 0.097), but inter group difference indicated that a significant decrease in the level of TNF-α in H-RT group (P = 0.004). The IL-6 levels showed a significant between-groups difference (P = 0.013) and also a significant decrease in the levels of IL-6 in H-RT group compared to L-RT group were observed (P = 0.049). Moreover, inter group analysis indicated significant decrease in the level of IL-6 only in H-RT group (P = 0.002). Conclusion: It seems that, the highest intensity circuit resistance training is more effective in downregulation of inflammatory mediators, and, in turn, the modulation of inflammation is associated with the decreased insulin resistance.}, Keywords = {Inflammation, Menopause, Obesity, Insulin resistance}, volume = {9}, Number = {1}, pages = {40-49}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-569-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-569-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Takalooei, Fatemeh and Shahrbanian, Shahnaz and C.Hackney, Anthony}, title = {Regulation of Metabolic Homeostasis by Reducing Selected Hepato-adipokines in Response to Three Types of Resistance Training in Men with Obesity}, abstract ={Abstract Introduction: Decreased physical activity is one of the main causes of the obesity epidemic. In the process of obesity, the secretion of some hepato-adipokines increases and causes metabolic disorders. Exercise plays an important role in improving the complications of obesity by regulating the levels of selected hepato-adipokine. The purpose of this study was to examine the effects of three types of resistance training methods on selected hepato-adipokine and lipid profiles in men with obesity. Materials and Methods: The sample of the study included 44 sedentary men with obesity divided into 4 groups of traditional resistance training (TRT), circuit resistance training (CRT), and interval resistance training (IRT) as well as one control group. Fetuin-A, Fetuin-B, high-density lipoproteins (HDL), low-density lipoproteins (LDL), total cholesterol (TC), and triglyceride (TG) were measured using the ELISA method. Results: The results of the mixed model ANOVA analysis showed a significant interaction between the type of training used and time at the levels of Fetuin-A (F (1, 40) = 94273.16, P = 0.001, ES = 1.00) and Fetuin-B (F (1, 40) = 49697.67, P = 0.001, ES = 0.99. In addition, within-group comparisons showed that lipid profile improved in TRT and CRT groups compared to the pretest (P = 0.001), while in the IRT group this improvement was not significant (P > 0.05). Conclusion: The result of the present study shows that three models of resistance training reduced the select hepato-adipokines level in comparison to the control group. However, IRT and CRT had the greatest effect on reducing Fetuin-A and Fetuin-B, respectively.}, Keywords = {Exercise, Adipose tissue, Hepato-adipokines, Fetuin-A, Fetuin-B, Metabolic disorder, Homeostasis}, volume = {9}, Number = {1}, pages = {50-61}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-652-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-652-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Omidi, Mehdi and Abedi, Rahebeh and Sobati, Elham and Sohrabnejad, Ali}, title = {Significant Association of COVID-19 with Ozone and PM2.5: A Case of Tehran, Iran}, abstract ={Introduction: Air pollution is one of the prime public health concerns influencing infectious diseases. From May 13 to July 29, 2020(77 days), Tehran experienced unhealthy conditions caused by high levels of O3 and PM2.5, whereas other pollutants remained at safe levels. This study, for the first time, sought to investigate the linkage between not only PM pollutants, but also O3 and the number of daily confirmed new cases of COVID-19 in Tehran, Iran. Materials and Methods: In this experimental study, the data on air pollution were obtained from an average of 23 air quality monitoring stations scattered in 20 districts of Tehran municipality during the 77days. Pearson’s correlation and log-linear generalized additive model (GAM) were used to examine the association of the daily numbers of confirmed cases of COVID-19 and levels of O3 and PM2.5. Also, effective degrees of freedom (edf) used to determine the structural relationship between independent and dependent variables. GAM was performed by R software (version 3.5.3) with the “mgcv” package (version 1.8-27). Results: The results show a significant relationship betweenO3, PM2.5, and COVID-19 (P <0.001), while other pollutants such as NO2, PM10, CO, and SO2 remain at healthy levels during the study period. Besides, O3 and PM2.5 with edfs greater than 1 had significant nonlinear effects on the daily number of COVID-19 cases (P < 0.001). Conclusion: Considering the results of this study, there is a positive nonlinear association between O3, PM2.5, and daily confirmed cases of COVID-19. These findings suggest that O3 and PM2.5 levels should be considered as influential factors that can aggravate coronavirus infection.}, Keywords = {COVID-19, Air pollution, GAM, Tehran}, volume = {9}, Number = {1}, pages = {62-68}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-611-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-611-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Moradnezhadi, Azizmorad and Pezhhan, Ali and Hejazi, Naser}, title = {Predicting the Aging Trend of Ilam Population and the Necessity for Implementing Health Services for the Elderly Until 2050}, abstract ={Introduction: The process of demographic transition has led to a change in the age of populations. Almost all countries around the globe have passed or are passing through the reproductive phase, which naturally contributes to the rising elderly populations. The present study was conducted to predict future trends of the elderly population in Ilam city. Materials and Methods: The secondary analysis method, population forecasting model, and scenario producing approach were used to assess demographic changes. Data analysis and the prediction of population features were performed using Spectrum and Mortpak software. Results: Among the important findings of this study was that the elderly population is rising in Ilam. Currently, the elderly population comprises 5% of the total population of Ilam, which will increase to more than 20% in 2050. Conclusion: Policy makers and managers should consider implementing social welfare and health care services for the elderly in the future.}, Keywords = {Population change, Futures studies, Ilam, Population projection, Aging}, volume = {9}, Number = {1}, pages = {69-75}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-586-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-586-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Cheraghi, Javad and Nooraei, Aref and Havasi, Marzieh and Soltani, Salm}, title = {Effects of the new coronavirus (covid19) on pregnancy and abortion: A systematic review}, abstract ={The new coronavirus (Covid 19) has become a hazardous threat due to its prevalence worldwide. Pregnant women are particularly vulnerable to this infectious disease because their immune system is already slightly compromised during pregnancy, making them more susceptible to viral infections. Therefore, the aim of this study was to investigate abortion due to this disease in different countries of the world. Thirty-six articles were analyzed by searching the web of science, Google Scholar, Pubmed databases for the following keywords: Covid 19 and abortion, Covid 19 and fetus, and Covid 19. Thirteen out of the 36 articles were used, and the rest were excluded from the study due to being unrelated to the subject. Articles related to the new coronavirus and abortion were then carefully studied and analyzed. It was shown in various studies that, due to the infection and immune system compromise during pregnancy, the Coronavirus could play a role in abortion and stillbirth. So, a prognosis of this threat could help pregnant women observe the health protocols during the pandemic more seriously so that they are more protected against being infected.}, Keywords = {Covid 19, Pregnancy, Abortion}, volume = {9}, Number = {2}, pages = {1-6}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-649-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-649-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Alivais, Elahe and Amini, Sabrieh and Haghani, Karimeh and Ghaneialvar, Hori and Keshavarzi, Fatemeh}, title = {Studying the effect of metformin and aerobic exercise on some biochemical factors in diabetic and healthy rats}, abstract ={Introduction: High-intensity interval training (HIIT) and moderate-intensity continuous training (MCT) in combination with metformin in diabetic patients is likely to be effective. This research aimed to investigate the possible role of HIIT and MCT training alone and also in combination with metformin on biochemical factors and lipid profiles in diabetic and healthy rats.     Materials and Methods: Sprague-Dawley rats were allocated randomly into nine groups (in each group n = 5). Streptozotocin and nicotinamide were used to induce diabetes in target rats. Special diets were given to all groups of rats and exercise protocol was performed one time per week for 8 weeks. Rats received metformin (200 mg/kg) daily by gavage. The biochemical factors and serum lipid profiles were measured. Data analysis was performed using SPSS software and the significance level was considered at P < 0.05.      Results: The lowest serum glucose and insulin levels among diabetic rats belonged to the diabetic group who received metformin and performed HIIT training (P < 0.05). Diabetic groups that performed HIIT and MCT training compared with the diabetic group that consumed metformin alone had lower HbA1c levels, which this difference was not significant (P < 0.05). The lowest triglyceride level among the treated diabetic groups was in the group that received metformin and performed HIIT training (P < 0.05). The results of HDL, LDL and cholesterol changes were similar to those found for triglyceride.     Conclusion: The study showed that both HIIT and MCT exercise, even in the absence of metformin, significantly reduce some biochemical factors and lipid profile levels as well as improve body weight in the diabetic rats under treatment with metformin compared with the diabetic control group.  }, Keywords = {Type 2 diabetes mellitus, Metformin, MCT training, HIIT training}, volume = {9}, Number = {2}, pages = {7-15}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-619-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-619-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {GhauorNajafAbadi, Azam and Keshavarz, Saieed and Kargarfard, Mehdi and BanaiiBoroujeni, Jamshi}, title = {Effect of Grape Seed Extract Consumption along with Moderate Intensity Aerobic Training on Some Biomarkers of Apoptosis of Cardiomyocytes in Wistar Rats with Type 1 Diabetes}, abstract ={Introduction: Today, diabetes is one of the leading causes of death in worldwide. Nutritional intervention and exercise training known as main strategies for control and management diabetes. The aim of the present study was to investigate the effect of grape seed extract consumption with moderate intensity aerobic exercise on some markers of cardiac myocyte apoptosis in male Wistar rats with type 1 diabetic. Materials and Methods: Forty adult male Wistar rats with an initial weight range of 160-220 g were divided into 5 groups of including diabetic / training + extract, diabetic / training, diabetic / extract, diabetic / control and healthy / control (8 heads per group). The rats of training groups performed aerobic exercise for 60 minutes a day at an average speed of 28 meters per minute (intensity equivalent to 70 to 75% of maximum oxygen consumption and training volume of 8.4 km per week). Grape seed extract was consumed by gavage with dosage of 40 mg / kg per day. All groups 48 hours after the last training session, was dissected and heart tissue was collected and Bcl-2, sFas and FasL analysis was performed. Results: Aerobic training and consumption of grape seed extract (both and each alone) significantly increased FasL and BcL-2 and also significantly decreased sFas and sFas/FasL in type 1 diabetic rats (P < 0.05); however, the combination of aerobic training and consumption of grape seed extract increased FasL and BcL-2 further and also decreased sFas and sFas/FasL in these rats compared to the training and consumption of the extract alone, which was a statistically significant difference (P < 0.05). Conclusion: By combining the antioxidant and anti-inflammatory effects of moderate-intensity aerobic exercise along with the consumption of grape seed extract, more anti-apoptotic effects may be induced in the myocytes of type 1 diabetic rats.}, Keywords = {Diabetes, Apoptosis, Grape seed, Aerobic training, Cardiomyocytes}, volume = {9}, Number = {2}, pages = {16-24}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-623-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-623-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Shahbazi, Reza and HatamiNemati, Homiera and Ahmadi, Hatam and Zogoulipour, Faezehe}, title = {Nociceptive threshold response and alterations of special genes expression during methamphetamine administration and treatment with buprenorphine}, abstract ={Introduction: Methamphetamine is a nerve stimulant. Buprenorphine has been widely used in the management of various types of pain and reducing addiction side effects. This study aimed to investigate the role of methamphetamine, buprenorphine, or their interaction on analgesic threshold and the expression of protein kinase B (AKT) and glycogen synthase kinase 3 (GSK3b) genes in the lumbar spinal cord of male rats. Materials and Methods: In this experimental study, 56 male Wistar rats (weight 200 ± 50 g) were randomly divided into eight groups: The control group, sham group, methamphetamine group, two buprenorphine groups, two methamphetamines + buprenorphine groups, and deprivation group. The drugs of methamphetamine and buprenorphine were injected intraperitoneal (i.p) for five days.  To measure the analgesic threshold, the Tail-Flick test was used. Additionally, the real-time PCR technique was applied to evaluate the expression levels of AKT and GSK3b genes in the lumbar spinal cord of male rats.  A one-way ANOVA test was used to analyze the data. Results: Intraperitoneal injection of methamphetamine (10 mg/kg) induced analgesia (P­ <­ 0.05) and increased the expression of the gene of AKT (P ­<­ 0.05) in the lumbar spinal cord of male rats. In addition, the injection of buprenorphine (6 and 10 mg/kg) potentiated the effect of methamphetamine on analgesia (P­ < ­0.01) and increased the expression of the GSK3b gene (P­ < ­0.05), whereas the higher dose of buprenorphine reduced the impact of methamphetamine on the expression of AKT gene (P­ <­ 0.05). Furthermore, the deprivation of methamphetamine, did not alter Tail Flick latency and the expression level of AKT and GSK3b genes. Conclusion: Our results indicated a possible reinforcing role of the buprenorphine on the increasing impact of acute methamphetamine injection on the expression of the GSK3b gene and analgesia.   }, Keywords = {Methamphetamine, Buprenorphine, Gene expression}, volume = {9}, Number = {2}, pages = {25-34}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-598-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-598-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Blori, Golbano and Abednatanzi, Hossein and Nikbakht, Hojjat Allah}, title = {The effect of eight weeks of HIIT on some angiogenesis indices of apelin-13 in elderly male rats}, abstract ={Introduction: Aging causes changes in metabolic, cardiovascular, and neuromuscular functions. By developing aging process, physical activity decreases, which is mainly due to fundamental changes in body composition and lack of angiogenesis for which some indicators of angiogenesis have been found in older male mice. The purpose of this study was to investigate the effect of high-intensity interval training (HIIT) on angiogenesis indices in elderly male rats. Materials and Methods: The  studied sample included 20 elderly male mice, which were randomly divided into two groups of control (n = 10) and experimental (n = 10). The experimental group repeated the HIIT in the specified intervals. The exercises were repeated after two minutes of rest, with 80% of the maximum speed in the first week, 90% in the second week, 100% in the third week, and 110% from the beginning of the fourth week, until the end of the training. To evaluate the research variables (VEGF, FGF21, NO, apelin-13), 3 ml of  peripheral blood was drawn from the tail of elderly male mice 72 hours before and after the last session of the training. Results: Eight weeks of HIIT significantly increased VEGF and NO  (P = 0.001). It also increased the FGF  and apelin-3 levels significantly (P = 0.0001). No significant change was observed in the control group. Conclusion: The results of this study showed that eight weeks of HIIT significantly increased angiogenesis levels in elderly male rats. Therefore, HIIT can be used as an appropriate and especially alternative exercise to increase angiogenesis in the elderly individuals.}, Keywords = {HIIT, VEGF, FGF21, Apelin-13, Angiogenesis, Elderly}, volume = {9}, Number = {2}, pages = {35-42}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-548-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-548-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Shohani, Fatemeh and Mihandoost, Zeinab and Mami, Sharam}, title = {The effect of assertiveness and stress management training on self-regulation and resilience building among adolescent female students}, abstract ={Introduction: The present study was conducted to evaluate the effect of assertiveness and stress management training on self-regulation and resilience building among adolescent female students. Materials and Methods: This quasi-experimental study was carried out among 102 female students in high schools of Ilam in 2020, selected by cluster sampling and randomly divided into three groups of assertiveness training, stress management training, and control. Data were collected using “The Connor-Davidson Resilience Scale (CD-RISC)” and “The Pintrich and De Groot's Motivated Strategies for Learning Questionnaire (MSLQ)” in two stages of pre- and post-test and were analyzed using MANOVA and ANCOVA statistical tests, while P < 0.05 was considered significant. Results: In the present study, assertiveness training was effective on self-regulation and resilience building by modifying pre-test scores (P = 0.001). Stress management training was effective on self-regulation building by modifying pre-test scores (P = 0.003). However, in the variables of trust in individual instincts, negative emotion tolerance, positive acceptance of change and safe relationships, control and spiritual effects, there is a significant difference between the mean post-test score of the stress management group and control after controlling the pre-test scores, which indicates the effectiveness of stress management training on resilience building (P = 0.001). Furthermore, assertiveness and stress management training had an effect on self-regulation and resilience building (P < 0.05). Conclusion: Among junior high school students, assertiveness and stress management training has been effective on self-regulation and resilience building among adolescent girls.  }, Keywords = {School girls, Stress management, Assertiveness}, volume = {9}, Number = {2}, pages = {43-51}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-637-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-637-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Naimian, Nazgul and ZarghamHajebi, Majid and Nokani, Mostaf}, title = {Comparison of the efficacy of cognitive rehabilitation and neurofeedback on specific learning disorder among primary school children of Tehran, Iran}, abstract ={Introduction: Specific learning disorder is an impairment in general academic skill that is identified in reading, mathematics and written expression fields; besides, it creates a major problem in academic achievement, job performance or daily life activities. The present study was aimed to compare the efficacy of cognitive rehabilitation with neurofeedback on specific learning disorder (math, reading and spelling) in primary school children in District 5 of Tehran. Materials and Methods: The methodology of this research was quasi-experimental with pre-test-post-test design with control group. Using the Learning Disability Evaluation Scale, 45 patients in three groups were selected as experimental group (15 patients for cognitive rehabilitation and 15 patients for neurofeedback) and control group (15 patients). Then, the interventions were provided to the experimental group and the control group used the usual school training. Pre-test and post-test were taken from both experimental and control groups, after the intervention on the experimental group, the pre-test and post-test results of all three groups were compared with each other. The Learning Disability Evaluation Scale (LDES-R2), developed by McCarney, was used in the study. Multivariate analysis of covariance, with SPSS 22 software was used for data analysis. Results: The results of the study showed that after the intervention, the treatment group was improved in the specific learning variables of reading, writing and math (P < 0.001). And the effect of cognitive rehabilitation approach was greater than the efficacy of neurofeedback (P < 0.001). Conclusion: By improving specific learning disorders in children, their problems might be reduced and the effect of treatment might be improved. Though, in case of specific learning disorders in the children, we would need much more thorough treatments.  }, Keywords = {Specific learning disorder, Reading disorder, Spelling disorder, Math disorder, Cognitive rehabilitation and Neurofeedback}, volume = {9}, Number = {2}, pages = {52-60}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-647-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-647-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {HashemiJokar, Seyedeh Elham and Peeri, Maghsoud and Azarbayjani, Mohammad Ali}, title = {The effect of high, low and moderate intensity circuit resistance training on the levels of hepatocyte-derived fibrinogen-related protein 1 (HFREP1) and lipid profile in obese postmenopausal women}, abstract ={Introduction: Different hepatokines including the hepatocyte-derived fibrinogen-related protein 1 (HFREP1) are secreted by liver tissue, which can affect the lipid metabolism. The aim of present study was to investigate the effect of 12 weeks circuit resistance training with different intensity on the levels of HFREP1 and lipid profile in obese postmenopausal women. Materials and Methods: Subjects of the study consisted of 44 postmenopausal women with average age of 56.07 ± 3.18 years old, dividing into the circuit resistance training with low (L-RT), moderate (M-RT), high (H-RT) intensity and the control groups (11 subjects in each group). Training program was conducted for 12 weeks and three session per week. Blood samples collected in pre and post-test stages and the levels of HFREP1 were measured by ELISA method and finally data was analyzed by Graphpad Prism software. Results: Analysis of HFREP1 data indicated that there were significant differences between different groups (P < 0.001). The results of Bonferroni post hoc-test showed that there was no significant difference between the control and L-RT groups (P > 0.05). However, HFREP1 in M-RT and H-RT groups significantly decreased compared to control group (P < 0.001). In addition, HFREP1 decrease in M-RT and H-RT groups was significant compared to L-RT group (P > 0.05). Lipid profile also improved in all trained groups, which further improvement observed in the H-RT group. Conclusion: It seems that, higher intensity circuit resistance training is associated with further decrease in the levels of HFREP1, and improving the lipid profile can be attributed partly to downregulation of HFREP-1 levels.}, Keywords = {Menopause, Circuit resistance training, Hepatokines, HFREP1}, volume = {9}, Number = {2}, pages = {61-70}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-570-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-570-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Dadfar, Reza and Arefi, Mahboubeh and FathiVajargah, Kourosh}, title = {Evaluation of the Curricula of Basic Sciences: A Study at Ilam University of Medical Sciences}, abstract ={Introduction: Curriculum management is essential for improving the quality of educational programs in healthcare. The structure of curriculum must be customized according to the scientific needs and requirements. Hence the present study aims to evaluate the Curricula of basic medical sciences from the experts point of views. Materials and Methods: In the study a combination of exploratory and Delphi research methods was used. At first, based on detailed studying of theoretical foundations, we extracted the first round of Delphi questions and provided them for the expert group. Using content analysis, the codes, categories, and finally, items were extracted. The items obtained were scored in a questionnaire based on the Likert scale, and then analyzed using descriptive statistics and Interquartile Range (IQR) metric. Results: According to the data extracted, the expert group identified the content of basic sciences curricula in Ilam University of Medical Sciences under the following categories: Content with low-level comprehensiveness, out-of-date content, content with low-level of practical application, bulky content, and content having a weak relationship with the objectives of the curriculum. Conclusion: Based on the research, the most significant problems of the basic sciences curricula were the low agreement of the content with educational objectives, low-level comprehensiveness, and finally, low-level practical application.}, Keywords = {Evaluation, Curriculum, Basic Sciences}, volume = {9}, Number = {3}, pages = {1-8}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-645-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-645-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Masoumi, Mansour and Rahimi, Mastoreh and Mami, Masoud and Bagheri, Maryam and Salari, Sajj}, title = {Mebeverine alleviates lower urinary tract symptoms in patients with irritable bowel syndrome}, abstract ={Introduction: Lower urinary tract symptoms (LUTS) are common in patients suffering from irritable bowel syndrome (IBS). LUTS are categorized into storage, voiding and post-micturition symptoms. Mebeverine, a voltage-gated sodium channel blocker, can alleviate IBS symptoms via inducing smooth muscle relaxation. The effect of mebeverine on LUTS is not cleared yet. Consequently, we aimed to evaluate the effect of mebeverine on LUTS in IBS patients. Materials and Methods: Seventy-five IBS patients were included in the present study. IBS was diagnosed according to the Rome IV criteria. International prostate symptom score (I-PSS) questionnaire was used to evaluate LUTS and quality of life in IBS patient. Patients were treated with 200 mg mebeverine per day. All patients were assessed once before the treatment and then one, three and six months after the treatment with mebeverine. Results: The prevalence and severity of voiding symptoms were significantly higher in males than females (P < 0.05). One-month treatment with mebeverine reduced storage and voiding urinary symptoms in IBS patients (P < 0.01 and P < 0.0001, respectively). The beneficial effects of mebeverine increased over the time and the maximum effect were found following six-months treatment (P < 0.0001). Furthermore, using mebeverine in IBS patients improved the quality of life both in men and women (P < 0.0001). Conclusion: Mebeverine could obviously ameliorate both gastrointestinal and urinary symptoms in IBS patients. These findings may propose that smooth muscle relaxants including mebeverine might be proper therapeutic agents for IBS patients with LUTS.  }, Keywords = {Irritable bowel syndrome, Lower Urinary Tract Symptoms, Mebeverine, Smooth muscle}, volume = {9}, Number = {3}, pages = {9-15}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-606-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-606-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {JahangirzadehSooreh, Gholamreza and KhalifzadehKalibar, Seyed Babak}, title = {Evaluating the Association of rs6500633 Polymorphism in the SEPT12 Gene with Idiopathic Asthenozoospermia in Iranian Azeri Males: A Case-Control Study}, abstract ={Introduction: SEPT12 gene encode a testis-specific protein that play important role in terminal differentiation of germ cells. The product of this gene involved in sperm tail annulus constituent, and is essential for head-tail formation in sperm. Various polymorphisms on SEPT12 gene are identified that are associated with impairment of sperm function as well as spermatogenesis in males with infertility. In this study we investigated correlation of rs6500633 polymorphism in the SEPT12 gene in Iranian Azeri male with idiopathic asthenozoospermia (AZS). Materials and Methods: We enrolled 50 men with idiopathic AZS as case group and 50 healthy men as control group from East Azerbaijan, Iran. Extraction of genomic DNA was conducted by proteinase K method from sperm samples. Genotyping was performed by tetra-primer amplification refractory mutation system-polymerase chain reaction (Tetra-ARMS PCR). Results: Frequency of TT, TC, and CC genotypes were 10%, 86%, and 4% in the AZS. On the other hand, the frequencies were 4%, 90%, and 6% in the healthy controls, respectively. Our study indicated no significant difference between the patient and control groups for frequency of the rs6500633 polymorphism in the SEPT12 gene (P > 0.05). Conclusion: We demonstrated no significant association between rs6500633 polymorphism in the SEPT12 gene and AZS among Iranian Azeri men.  }, Keywords = {Asthenozoospermia, SEPT12 Gene, Polymorphism, Tetra-ARMS PCR}, volume = {9}, Number = {3}, pages = {16-22}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-536-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-536-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Masih, Zahra and Hoghooghirad, Nasser and Madani, Rasool and Sharbatkhori, Mitr}, title = {Human Hydatid Cyst Zoonotic Characters and analysis of P29 Recombinant Protein Immunogenicity}, abstract ={Introduction: Echinococcosis or hydatid disease is one of the most important zoonosis across the world. Materials and Methods: The recombinant P29 protein is considered as a suitable candidate for evaluating diagnostic ELISA to reach a more accurate conclusion. Results: In this study the P29 sequence comprised with somewhat similar sequences registered in Gene Bank and showed 100% identity with P29 sequences derived from Echinococcus granolosus (E. granulosus) (XP_024351425.1), E. multilocularis (AHA85396.1), Endophilin B1 protein of E. granulosus (CDS21096.1). The primary and secondary structure of the peptide was analyzed due to its characterization of peptide motifs to be expressed on MHC Class HLA allels. Conclusion: The recombinant P29 derived peptides can be produced and analyzed due to be determined as vaccine design candidate against Hydatidosis.  }, Keywords = {Echinococcus granolosus, Hydatidosis, MHC, P29, Recombinant Antigen}, volume = {9}, Number = {3}, pages = {23-30}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-722-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-722-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Cheraghian, Mojtaba and Pourfallah, Tayyeb and Sabouri-Dodaran, Amir Abbas and Gholami, Mehr}, title = {Calculation of photoneutron contamination of Varian linac with new target in tissue equivalent phantom using Monte Carlo simulation}, abstract ={Introduction: In this research, a new material (Ti2V0.7Cu97.3) was proposed for the target of medical linear accelerators (linacs) to reduce the production of unwanted photoneutrons in the radiotherapy. So, the fluence, dose equivalent and kerma of the photoneutrons were calculated in a soft tissue phantom. Materials and Methods: The medical linac was the Varian 2100 C/D 18 MV, which its tungsten target was replaced with a new multi-metal target (Ti2V0.7Cu97.3). Desired quantities were computed in a ICRU soft tissue phantom, using the Monte Carlo code MCNPX (v. 2.6). Results: The ratio of the maximums of fluence, kerma, and dose equivalent of photoneutrons along the central axis of the ICRU phantom with new target rather than tungsten target were 72 %, 59 % and 61 %, respectively. Average of the Ratio of fluence, kerma, and dose equivalent in inner area (distances less than 5 cm from central axis) at different depths of the phantom with new target rather than tungsten target were 78 %, 70 % and 75 %, respectively. Uncertainties at all points were less than 5 % (except for a few points which were less than 10 %). Conclusion: This work showed that applying Ti2V0.7Cu97.3 alloy for the target of linac, can reduce the produced photoneutrons up to 38 % by an applicable and inexpensive way.  }, Keywords = {MCNPX, Photoneutron contamination, Simulation, Target of linac}, volume = {9}, Number = {3}, pages = {31-41}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-681-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-681-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Jadid, Alireza and Gholami, Mandana and AbedNatanzi, Hossei}, title = {Effect of eight weeks combined training and Zataria multiflora supplement on the levels of IL-1β and insulin resistance in overweight and obese men}, abstract ={Introduction: The anti-inflammatory effects of exercise training and zataria multiflora have been proven. In the present study, researcher investigated the effect of eight weeks combined exercise training and Zataria multiflora (Z. multiflora) supplement on the levels of IL-1β and insulin resistance in overweight and obese men. Materials and Methods: The 40 overweight and obese men with average age of 27.73 ± 2.15 years old and average body mass index (BMI) 28.41 ± 1.75 kg/m2 were randomly divided into four groups including the placebo, Z. multiflora, combined training, and training + Z. multiflora. Combined exercise training program conducted for eight weeks and three sessions per week. Z. multiflora supplement was also consumed at 500 mg daily. Blood sampling was performed before and 48 hours after the eight weeks intervention. The levels of IL-1β and insulin were measured by ELISA method. Data were analyzed by analysis of covariance and Bonferroni post hoc test. Results: The levels of IL-1β in training and training + Z. multiflora groups significantly decreased compared to placebo and Z. multiflora groups (P < 0.001). In addition, significant decrease of insulin resistance in training group compared to placebo (P < 0.001) and Z. multiflora (P = 0.003) groups, and also in training + Z. multiflora group compared to placebo and Z. multiflora groups were observed (P < 0.001). Conclusion: Combined training alone or in combination with Z. multiflora supplementation can exert anti-inflammatory effects. Moreover, Z. multiflora supplementation cause the relative increase in exercise training effect for decrease in IL-1β and insulin resistance.  }, Keywords = {Exercise Training, Zataria Multiflora, Inflammation, Cytokine}, volume = {9}, Number = {3}, pages = {42-50}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-603-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-603-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Sobhanipoor, Mitra and Nouri, Reza and Gaeini, Abbasali}, title = {The response of selected adipokines and insulin resistance to interval resistance training with different intensities in men with obesity}, abstract ={Introduction: This study aimed to evaluate the effect of 12 weeks of interval resistance training with different intensities (low, medium and high) on bone morphogenetic protein 2 (BMP-2), bone morphogenetic protein 4 (BMP-4) and insulin resistance in obese men. Materials and Methods: Forty-four obese not trained men, after determining 1RM and based on anthropometric characteristics were divided into the control, low-intensity interval resistance training, medium-intensity interval resistance training, high-intensity interval resistance training groups (in each group, n=11). The protocol of interval resistance training includes 8 movements which were periodic and in different intensities in the form of 3 Set 10 repetitions with 80% 1 RM, rest between sets active, and with 20% intensity and the number of repetitions 15 in the high-intensity group, in the medium intensity group in the form of 3 sets 13 repetitions with 60% RM, resting active sets with 20% intensity and number 15 repetitions and in the low-intensity group in the form of 3 sets of 20 repetitions with 40% 1 RM, rest between sets was active with 20% intensity and the number of repetitions was 15. The first fasting blood sample was obtained 48 hours before and the second blood sample was collected 48 hours after a twelve-week training period. Then the measurements were performed. Results: The 12 weeks of interval resistance training with different intensities in the training groups led to a significant decrease in BMP-2 and insulin resistance compared to the control group (P < 0.001) but for BMP-4 these decreases were not significant (P = 0.055). Conclusion: The study showed that different intensities of resistance interval training, especially moderate and high intensity training, can decrease the BMP-2, BMP-4 levels and improve insulin resistance.}, Keywords = {Interval resistance training, Obesity, Adipokine, Insulin resistance}, volume = {9}, Number = {3}, pages = {51-60}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-677-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-677-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Cheragh-Birjandi, Sadegh and Baghernejad, Maryam and Haghighi, Farideh and Ganji, Reza and Saadati, Hasan and Jafari, Mohammadrez}, title = {Effect of resistance exercises and nano-curcumin supplementation on matrix metallopeptidase 13 and cartilage oligomeric matrix protein in women with knee osteoarthritis: a clinical controlled study}, abstract ={Introduction: This study aimed to investigate the effect of resistance training and nano-curcumin supplementation on matrix metallopeptidase 13 (MMP13) and cartilage oligomeric matrix protein (COMP) in patients with knee osteoarthritis. Materials and Methods: In this open-label parallel randomized trial study 40 women aged between 45-60 years with knee osteoarthritis (OA) were randomly divided into the control, resistance training, nano-curcumin supplementation, and resistance training + nano curcumin supplementation groups. Socio-demographic characteristics, anthropometric and clinical parameters of the patients (WOMAC test) were collected at the beginning and end of the study. The levels of MMP 13 and COMP in the synovial fluid were measured with a human-specific ELISA kit. Results: Resistance training, supplement intake, and training/supplementation did not significantly change the synovial levels of COMP and MMP 13. Compared with the control group, WOMAC scores were significantly higher in the intervention groups (P = 0.038). Conclusion: Resistance training and nano-curcumin by changing the WOMAC scores of patients with osteoarthritis can have a beneficial effect on improving the condition of these patients.  }, Keywords = {Nano-curcumin, MMP13, Resistance exercises, Cartilage oligomeric matrix protein}, volume = {9}, Number = {3}, pages = {61-70}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-655-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-655-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Maddahi, Seyedeh Zahra and Jokar, Assie and Behnampur, Nasser and Kamalinejad, Mohammad and Fakhri, Molou}, title = {Effects of Ziziphus jujuba on the Prevention of Drug Induced Liver Enzyme Disorders in Pulmonary Tuberculosis Patients: Protocol for Randomized controlled trial}, abstract ={Liver damage is the most common complication of anti-tuberculosis drugs, but there is currently no standard prevention for it. The main purpose of this study is to determine the effectiveness of Ziziphus jujuba (Z. jujuba) syrup on the prevention of liver enzyme disorder in TB patients. This study is a protocol for randomized controlled trial. 48 patients will be included in the study who will be randomly assigned to one of the two groups of Z. jujuba syrup or placebo syrup based on the block randomization. Liver enzyme tests are measured at the beginning of the study, as well as days 14 and 28 of the study, which will be the primary outcome. The standard Visual Analog Scales questionnaire will be completed on days 0, 14, and 28 to assess cough, anorexia, and nausea in patients. The standard SF-36 quality of life questionnaire will be completed on days 0 and 28 of the study, which will be evaluated as the secondary outcome of the study. The hypothesis of the study is that the incidence rate of liver enzyme disorder will be lower in patients treated with Z. jujuba, compared to those who received the placebo.  }, Keywords = {Tuberculosis, Ziziphus jujuba, Liver enzyme disorder, Protocol study, Clinical trial}, volume = {9}, Number = {4}, pages = {1-11}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-644-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-644-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Toktam-Barmar, Zahra and Cheragh-Birjandi, Sadegh and Rezaeian, Najmeh}, title = {High intensity aerobic interval training and curcumin supplementation could control hippocampal neurotoxicity induced by oxygenated water consumption in male rats}, abstract ={Introduction: Tissue dysfunction might be the result of reactions between free radicals and cell membranes. The purpose of this study was the evaluation of cell vulnerability and assessment of the effect of intense intermittent exercise and curcumin supplementation on apoptotic and antiapoptotic factors in Wistar rats. Materials and Methods: For the study, 60 adult male Wistar rats were randomly divided to 5 groups (n = 8) of saline, hydrogen peroxide (H2O2), high intensity interval training (HIIT) + oxygenated Water, Curcumin Supplement + Oxygenated Water, and HIIT + Curcumin Supplement + Oxygenated Water. Rats were treated with H2O2 in the amount of 1 mmol/kg of body weight three times a week on even days and curcumin, 150 m g/kg of body weight, daily. Treadmill running program was performed for 8 weeks. Real-time PCR was applied to assess Bcl-2-associated X protein (Bax) and B-cell lymphoma 2 (Bcl-2) genes expression. Data were analyzed by using the Two-way ANOVA. Results: The induction of oxidative stress by H2O2 increased expression of Bax, and decreased expression of Bcl-2 in hippocampus of rats (P = 0.0001). HIIT and curcumin supplementation decreased expression of Bax, and increased expression of Bcl-2, Also, decreased the Bax/Bcl-2 ratio (P = 0.0001). Conclusion: This finding showed that doing HIIT and taking curcumin supplements have been able to decreas oxidative stress, and the effect of both together could further reduce the apoptotic process.  }, Keywords = {Oxidative stress, HIIT, Hydrogen peroxide, Bax, Bcl}, volume = {9}, Number = {4}, pages = {12-20}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-668-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-668-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Tabe, Raha and Javidi, Hojjatolah and Rezaee, Azarmidokht and Ghasemi, Nowsh}, title = {The role of feeling of security in the relationship between psychological capital, social capital and social health in Shiraz government employees}, abstract ={Introduction: According to the Global Mental Health Movement, security provides a coherent conceptual framework and an ethical basis for the development of the mental health system. Therefore, mediating the role of the sense of security in the relationship of psychological capital and social capital with social health was investigated among government employees in Shiraz. Materials and Methods: In this descriptive-correlational (structural equation) model, 705 government employees (255 females and 450 males) in Shiraz were selected as the sample group. Data were collected by Psychological Capital, Standard Social Capital, Security Feeling, and Social Health Questionnaires. The analysis of data was performed with the aid of Pearson’s correlation coefficient and structural equation modeling using the SPSS 20 and LISREL 8.80 software. Results: The results showed no statistically significant difference between the gender, age, and workplace of the study subjects (P > 0.05). Also, the performance indices were in good condition at REMSA = 0.01, GFI = 0.96, CFI = 0.91, RFI = 0.90, and NFI = 0.91. Standard coefficients of the direct and indirect effects of psychological and social capital on social health were significant based on the feeling of security (P < 0.05 for both). Conclusion: Our findings revealed that health reflects social factors and a sense of security, and the improvement of social health is dependent on providing and strengthening a sense of security.  }, Keywords = {Psychological capital, Social capital, Sense of security, Social health}, volume = {9}, Number = {4}, pages = {21-27}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-634-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-634-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Naghibzadeh, Maryam}, title = {Evaluating the Correlation of Physical Fitness and Happiness among College Students}, abstract ={Introduction: Physical activity has a significant impact on the quality of life and mental health of college students. The importance and role of happiness in mental health and social participation have been one of the most important priorities of psychology researchers. Also, very few studies have been conducted on happiness among college students, especially females, so the present study aimed to determine the correlation between physical fitness and happiness among female university students. Materials and Methods: This research was a descriptive and correlational study. The participants consisted of a group of 124 females (aged 20.94 ± 1.82 years) who were selected randomly from Ilam university students. The AAHPERD battery was used to obtain the physical fitness grade of the students and the Oxford questionnaire was used to calculate their happiness. The data were analyzed by SPSS software and the Pearson correlation coefficient. Results: Results of this study indicated a significant relationship between physical fitness and happiness (r = 0.293, P = 0.048). Conclusion: The research indicated that exercise and physical activity effectively improve students' happiness and suggested that it must pay more attention to sport programs and increase university student's physical fitness.}, Keywords = {Physical Fitness, Happiness, University Students}, volume = {9}, Number = {4}, pages = {28-33}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-675-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-675-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Kooti, Mahrokh and Soori, Rahman and Shabkhiz, Fatemeh and Pournemati, Paris}, title = {The effect of three month combined training on the serum levels of interleukin-6 and C-reactive protein in sedentary obese women}, abstract ={Introduction: Combined training play important role in improving body composition, but less is known about its anti-inflammatory mechanism in obesity. Researcher in the present study investigated the effect of three-month combined exercise training on the serum levels of interleukin-6 and C-reactive protein in sedentary obese women. Materials and Methods: The 24 obese women age ranging 20-35 years old with average body mass index (BMI) 32.02±1.03 kg/m2 randomly allocated in 2 groups (12 participants in each group) including control and combined training (endurance-resistance) groups. Exercise training program conducted for 12 weeks and three session per week. Endurance training intensity was 60 percent of reserve heart rate and resistance training intensity was 75 percent of 1RM. Blood samples collected before and after 12 weeks training program and IL-6 and CRP levels were measured by Elisa method. Data were analyzed by means of SPSS software version 24 with analysis of covariance test. Results: Present study findings indicated that serum levels of IL-6 in combined training group significantly decreased compared to control group (P < 0.001). In addition, significant decrease in CRP levels were observed in combined training group compared to control group (P = 0.0188), which decrease in inflammatory mediators was associated with significant decrease in percent body fat in combined training group (P < 0.001). Conclusion: According to present study, combined training plays an important role in down-regulation of inflammatory mediators and the anti-inflammatory effect may be related to decrease in body fat mass as a main source for secreting the inflammatory mediators including CRP and IL-6.  }, Keywords = {Exercise Training, Cytokine, Interleukin-6, Inflammation}, volume = {9}, Number = {4}, pages = {34-44}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-679-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-679-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Gharani, Hadi and Rahmati, Masoud and Mansouri, Rahim}, title = {The effect of 24 weeks of resistance training on lipid profile, HBA1c, and insulin resistance in middle-aged women with type 1 diabetes}, abstract ={Introduction: Exercise training has been associated with health outcomes in diabetes, but the effect of long-term resistance training on HBA1c is largely unknown. Therefore, the present study was conducted to determine the effects of resistance training on lipid profile, HBA1c, and insulin in women with type 1 diabetes Materials and Methods: In this semi-experimental study, 20 women (n =10, with an average age of 54.50 ± 8.16 years, a height of 158.16 ± 5.36 cm) were randomly assigned into two control and experimental groups. A pre-test of the desired indicators (weight, height, waist circumference, hip circumference, fat percentage, fasting blood sugar, and glycosylated hemoglobin level) was performed for both groups. The experimental group performed a circuit resistance activity course (12 stations, 4 rounds, three days a week for 24 weeks). At the end of this period, the desired indicators were evaluated again as a post-test. To interpret the data, analysis of covariance (ANCOA) was used, considering the pre-test as a covariate. Results: Resistance training for 24 weeks reduced LDL level (P = 0.001), TG (P = 0.001), BF (P = 0.002), WHR (P = 0.033), FBS (P = 0.001), HBA1c (P = 0.001), Insulin (P = 0.001), HOMA-IR (P = 0.001), and increased VO2max (P = 0.001) and average HDL-C (P = 0.001) in the experimental group compared to the control group. However, there was no significant difference in average BMI (P = 0.129), TG (P = 0.073), and Waist circumstance (P = 0.195) in the control and experimental groups. Conclusion: Based on the results of the present study, long-term resistance training improves lipid profile, HBA1c, and insulin levels in middle-aged women with type 1 diabetes.  }, Keywords = {Diabetes mellitus, Resistance training, HBA1c, Indicators related to diabetes}, volume = {9}, Number = {4}, pages = {45-56}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-736-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-736-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Zakariaee, Seyed Salman and Hashemi, Hasan and Salmanipour, Hossei}, title = {Comparison of singular value decomposition and Fourier deconvolution methods for cerebral blood flow quantification in dynamic contrast-enhanced magnetic resonance imaging}, abstract ={Introduction: Glioma grading is an important clinical procedure that determines the procedure of the patient's treatment. There is an increasing interest in other complementary techniques in addition to histo-pathological evaluation as the gold standard method. Perfusion indices have shown promising correlations with histo-pathological grades and neovascularization degrees in gliomas. In this study, the processing times and classification performances of cerebral blood flow (CBF) parameters calculated using singular value decomposition (SVD) and Fourier deconvolution methods were evaluated. Materials and Methods: The statistical differences between the CBF magnitudes of the high- and low-grade gliomas were evaluated for eighteen patients with pathologically proven gliomas (Low-grade gliomas, 5; High-grade gliomas, 13). The classification performances of the calculated indices were evaluated using the receiver operating curve analysis. Results: The deconvolution processing times for the SVD method were significantly higher than those of the Fourier deconvolution method (about ~9 times). There were statistically significant differences in both CBF indices between the high- and low-grade gliomas (P<0.05). In ROC curve analysis, CBF indices calculated by the SVD method had a higher area under the curve (about 8538.5 vs. 8153.8). Conclusion: Based on the study, the glioma grade might be determined using the Fourier-based CBF index with an almost similar grading efficiency and a much lower processing time than the CBF index calculated by the SVD method.  }, Keywords = {Glioma grading, Dynamic contrast-enhanced MRI, Cerebral blood flow, Singular value decomposition, Fourier deconvolution}, volume = {9}, Number = {4}, pages = {57-68}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-571-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-571-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} } @article{ author = {Arabnejad, Najmeh and Ghazalian, Farshad and Najafipour, Hamid and AbedNatanzi, Hossei}, title = {The Effect of Endurance Training on The Serum and Cardiac Levels of Malondialdehyde in the High Fat Fed Male Rats}, abstract ={Introduction: Malondialdehyde (MDA) is known as an important biomarker for assessing oxidative stress, which exert many pathological effects. The present study sought to investigate the effect of endurance training on the serum and cardiac levels of malondialdehyde (MDA) and lipid profile in the high fat fed male rats. Materials and Methods: For the 21 male Wistar rats (weighing 200-250g) randomly assigned in three equal groups including the control (C; received normal diet), 60% high-fat diet (HF), and 60% HF + endurance training group (HFE). The HF and HFE groups received 60% calories from fat for 12 weeks. Subsequently, endurance training program performed for six weeks (5 session per week) by the HFE group. Following completing intervention, blood and heart tissue samples collected, and the MDA and lipid profile were measured. Data were analyzed by SPSS-24 software, using one-way ANOVA test. Results: Serum MDA in the C and HFE groups was significantly lowered compared to the HF group (P < 0.05). Cardiac MDA also represented a significant decrease in the C and HFE groups compared to the HF group (P < 0.05).  Moreover, endurance training result in significant improvement in the lipid profile compared to the HF group (P < 0.05). Conclusion: It seems that exercise training can be considered as an effective strategy for ameliorate the pathological effect of high fat feeding, partly exerted by downregulation of serum and cardiac MDA levels and the lipid profile improvement.  }, Keywords = {High fat diet, Endurance training, Malondialdehyde}, volume = {9}, Number = {4}, pages = {69-76}, publisher = {ilam university of medical sciences}, url = {http://jbrms.medilam.ac.ir/article-1-702-en.html}, eprint = {http://jbrms.medilam.ac.ir/article-1-702-en.pdf}, journal = {Journal of Basic Research in Medical Sciences}, issn = {2383-0506}, eissn = {2383-0972}, year = {2022} }