2024-03-29T00:47:54+04:30 http://jbrms.medilam.ac.ir/browse.php?mag_id=19&slc_lang=en&sid=1
19-351 2024-03-29 10.1002
Journal of Basic Research in Medical Sciences 2383-0506 2383-0972 doi 2018 5 3 A model to predict low birth weight infants and affecting factors using data mining techniques Shiva Ghaderighahfarokhi Shivaghaderi92@gmail.com Jamil Sadeghifar Jamil.Sadeghifar@gmail.com Mossayeb Mozafari Mozafaric@yahoo.com Introduction: Birth weight is a reliable indication of intrauterine growth and determines the child's future physical and intellectual development. The purpose of this study was to use data mining technique in identifying accurate predictors of (low birth weight) LBW. Materials and methods: This study used secondary data from 450 medical records of newborns in the educational Hospitals affiliated to Ilam University of Medical Sciences. The birth records were reviewed from April 2015 to April 2016.  The checklist used to collect data comprised of two parts: demographic and effective factors (13 factors of medical and neonatal, 4 factors of mother's lifestyle and 8 about mother factors). Data were analyzed by SPSS version 21 and WEKA software. Results: Our findings showed that mean weight of infants was 2289 ± 864 gr. The mean gestational age was 35.2 ± 4.63 weeks. 14.9% of mothers suffer from placenta previa and 14.4% suffer from preeclampsia. The results of ANOVA showed that neonatal weight was significantly higher among mothers with weight range of 84-110 Kg. The random forest algorithm showed that gestational age less than 36 weeks is main predictor and number of fetuses, preeclampsia, and premature rupture of membrane, placenta previa, the number of pregnancies and the degree of mother education were other predictors of low birth weight. Conclusion: This study confirmed that low birth weight is a multifactorial condition requiring a systematic and accurate program to reduce LBW. Individual and group education through mass media, repeated monitoring of pregnant mothers, activation of the referral system and pursuit of a family health care technician may reduce prevalence of LBW. Low birth weight Data mining Gestational age 2018 6 01 1 8 http://jbrms.medilam.ac.ir/article-1-351-en.pdf 10.29252/jbrms.5.3.1
19-359 2024-03-29 10.1002
Journal of Basic Research in Medical Sciences 2383-0506 2383-0972 doi 2018 5 3 Designing of potential vaccine candidates of fused cathepsin L and tropomyosin genes of Rhipicephalus (Boophilus) annulatus tick larva Zahra Asadollahi asadollahi.z@ut.ac.ir Sedigheh Nabian nabian@ut.ac.ir Mohammad Taheri Taherim@ut.ac.ir Elahe Ebrahimzadeh eebrahimzade@ut.ac.ir Mohammad Mehdi Ranjbar mm.ranjbar.phd@gmail.com Introduction: Regarding emerging tick resistance against acaricides, researches have been shifted toward alternative approaches such as immunologic methods. Vaccine preparation is an alternative way in which choosing appropriate protein with high immune induction potency is a prerequisite. In addition according to studies, using more than one protein could better enhance the immune induction and antibody production. Choosing immunogenic epitopes from selected proteins and adjoining them with a suitable linker is one of the novel approaches in vaccine design. Materials and methods: Based on the fact that both cathepsin and tropomyosin proteins of Rhipicephalus tick were previously recognized as potent immunogenic antigens, we predicted the immunogenic epitopes of these proteins by immunoinformatic methods. Among studied epitopes, those that were met by multiple bioinformatics tools were used. Results: Finally, the polytopic construction was designed by assembling the selected epitopes and connecting them with linkers. Conclusion: Using immunoinformatic tools, we predicted the characteristics of two genes of Rhipicephalus annulatus tick larva as fused potent vaccine candidates namely, cathepsin and tropomyosin.   Tropomyosin Cathepsin Rhipicephalus annulatus vaccine design Iran 2018 6 01 9 16 http://jbrms.medilam.ac.ir/article-1-359-en.pdf 10.29252/jbrms.5.3.9
19-320 2024-03-29 10.1002
Journal of Basic Research in Medical Sciences 2383-0506 2383-0972 doi 2018 5 3 Evaluation of thinking style among medical and dental students of Ilam University of Medical Sciences in academic year of 2016-2017 Sareh Shakerian Rostami sarehshakerian@gmail.com Ali Sohrabnejad asnsohrabi@gmail.com Alireza Mirzaei Introduction: Education and research are two thinking based processes. Nowadays, the main function of educational institutions is evaluated by thinking. This study aimed to determine the dominant thinking styles among medical and dental students of Ilam University of Medical Sciences (IUMS). Materials and methods: This cross-sectional study was conducted on all medical and dental students of IUMS in the academic year of 2016-2017. Data was collected by Sternberg’s standard thinking style inventory and a demographic data questionnaire. Data analysis was carried out with the software SPSS 20 using descriptive statistical analysis methods and t-test. Results: In total, 497 students of IUMS participated in the study. Among whom 395 (79.5%) were medicals students and 102 (20.5%) were dental students. The findings showed significant differences between the legislative and executive thinking styles of medical and dental students (P=0.042 and P=0.024 respectively), more specifically, the mean score of legislative thinking style was found to be higher among dental students than that of medical students, and the opposite relation was found in the mean scores  of executive thinking style. Comparison of mean scores of thinking style dimensions between medical and dental students showed significant differences in some but not all dimensions. Conclusion: Considering the differences found in thinking styles of medical and dental students and their effects in emergence of unique behavioral and decision-making characteristics in medical and dental students, educational planners and professors should attempt to adjust their teaching methods and professional approach according to students individual features in terms of thinking style and preferences so as to foster the growth and flourish of their thinking, academic, and clinical capabilities. The results of the study showed significant differences between the legislative and executive thinking styles of medical and dental students, also regarding the different dimensions of thinking styles of medical and dental students, some significant differences in some but not all dimensions were reported. Thinking Thinking style Medical and dental students 2018 6 01 17 22 http://jbrms.medilam.ac.ir/article-1-320-en.pdf 10.29252/jbrms.5.3.17
19-355 2024-03-29 10.1002
Journal of Basic Research in Medical Sciences 2383-0506 2383-0972 doi 2018 5 3 Oral administration of triethylenetetramine (TETA) reduces some inflammatory markers in streptozotocin-induced diabetes mellitus in rat Kaveh Azimzadeh kaclinpath@gmail.com Hossein Jafarpour jafarpour_h@yahoo.com Farid Digeleh digale_f@yahoo.com Armin Gargarechi gargarehchi_a@yahoo.com Introduction: Owing to harmful effects of inflammatory markers on occurrence and progression of diabetic complications, hence, studying the possible effect of chemical components on these markers seems to be effective in diabetes mellitus. This study aimed to assess whether the triethylenetetramine (TETA), as a copper chelator, affects the plasma level of inflammatory markers such as visfatin (Vis), cholinesterase (CholE), total sialic acid (TSA) and hepcidin (Hep) in streptozotocin- induced diabetes mellitus rat. Materials and methods: Thirty male Wistar rats were assigned for this study. After induction of diabetes mellitus, TETA with different doses (10, 20 and 40 mg/kg/day) was orally administrated for 6 months. Thereupon, the above inflammatory factors were measured in all treatment groups. Results: Plasma concentrations of Vis, CholE, TSA, Hep and glucose decreased significantly (P<0.01) in the highest dose group (40 mg/kg/day) compared with control group. Interestingly, by enhancement of TETA dose, these levels were lowered. Conclusion: The results suggested that TETA administration in the dose of 40 mg/kg/day leads to profound reduction of the inflammatory markers Vis, CholE, TSA and Hep, therefore may have beneficial effect on diabetes mellitus. Triethylenetetramine Diabetes mellitus Novel inflammatory markers 2018 6 01 23 31 http://jbrms.medilam.ac.ir/article-1-355-en.pdf 10.29252/jbrms.5.3.23
19-319 2024-03-29 10.1002
Journal of Basic Research in Medical Sciences 2383-0506 2383-0972 doi 2018 5 3 An assessment of agility in selected hospitals of Mazandaran province, Iran Ghahraman Mahmoudi Ghahraman48@yahoo.com Masoomeh Abdi Talarposhti talarposhtiabdi@yahoo.com Introduction: Evaluating agility effectively and efficiently is necessary and challenging for organizations. Therefore, this article aimed to assess the performance of hospitals with organizational agility (OA) approach. Materials and methods: A descriptive-analytical study was done in which the statistical population consisted of managers and experts of hospital courses including medicine, nursing, midwifery, and paramedics. A total of 283 managers and experts were enrolled as the sample using the Krejcie and Morgan table with stratified random sampling. Data were analyzed using one-sample t test with SPSS20. Results: Among 13 elements of agility, the results showed that competence (P=0.032) had a significant difference with customer satisfaction (P=0.029). The results also showed that OA was not optimal in selected hospitals of Mazandaran province, Iran. Concerning the indicators, introduction of new product (8.56) and staff skill development indicator (5.32) were maximum and minimum, respectively. Conclusion: The results showed that OA was not optimal in selected hospitals. Introduction of new product scored the top, while staff skill development was the lowest. As a result, health policy makers are recommended to plan for customer satisfaction, timely utilization of facilities, elimination of weak points, lost cost reduction, encouragement and punishment system for staff, and staff empowerment. Organizational agility Accountability Competence Flexibility Speed Hospital 2018 6 01 32 41 http://jbrms.medilam.ac.ir/article-1-319-en.pdf 10.29252/jbrms.5.3.32
19-368 2024-03-29 10.1002
Journal of Basic Research in Medical Sciences 2383-0506 2383-0972 doi 2018 5 3 Comparison of high-intensity interval versus low-intensity continuous training for myelin synthesis related genes in C57BL/6 mice Maryam Naghibzadeh naghibzadehmaryam@yahoo.com Rouhollah Ranjbar r.11ranjbar@gmail.com Mohammad Reza Tabandeh mtabandeh06@gmail.com Abdolhamid Habibi ma1.minaee@gmail.com Zohreh Ghotbeddin mnaghib4@gmail.com Abstract  Introduction: By increasing the scientific focus on myelination, identifying factors that influence the myelination is an important goal for brain health. There are some studies that regular exercise improves myelin sheath and neuronal regeneration. However, the effects of exercise intensities on the myelination remain unclear. Therefore, the purpose of this study was to compare the effect of high-intensity interval (HIIT) versus low-intensity continuous training (LICT) on myelin synthesis-related genes in hippocampus of C57BL/6 mice. Materials and methods: Male C57BL/6 mice (n = 30) were randomly assigned to 3 groups: control (C), Interval training (IT), and Continuous training (CT). Training programs on the treadmill were performed for 8 weeks and then, the hippocampus of animals was analyzed for the expression of myelin basic protein (MBP) and proteolipid protein (PLP) genes. Data were analyzed using ANOVA. Results: The result showed that HIIT program significantly increased the mRNA levels of MBP and PLP in comparison with LICT and Control groups (P<0.05), while no significant differences were observed among the LICT and Control groups (P>0.05). Conclusion: Our results showed that HIIT had a more efficient by improving the expression of MBP and PLP genes compared to LICT in the hippocampus. Interval training Continuous training Myelin basic protein Proteolipid protein Hippocampus 2018 6 01 42 48 http://jbrms.medilam.ac.ir/article-1-368-en.pdf 10.29252/jbrms.5.3.42
19-376 2024-03-29 10.1002
Journal of Basic Research in Medical Sciences 2383-0506 2383-0972 doi 2018 5 3 Age related changes in clinicopathologic features of oral squamous cell carcinoma (OSCC) in Iranian patients: An epidemiologic study Ramin Ghafari ramin.ghaffari.s3@gmail.com Noushin Jalayer Naderi jalayer@shahed.ac.ir Amirnader Emami Razavi razavinader@gmail.com Introduction: Clinicopathologic characteristics of oral Squamous cell carcinoma (OSCC) affected by age, although it is controversial. In this study the differences in clinicopathological features of OSCC were compared between patients younger and older than 40 years' old. Materials and methods: In this retrospective study the histopathologic records of OSCC patients who underwent surgery in Cancer Institute of Iran during 2005-2015 were retrieved. The demographic and histopathologic features of patients in two groups of younger than 40 and older than 40 years old were recorded and descriptive analysis was used for statistical interpretation between groups. Results: The most cases of OSCC in both groups was registered in males with 14.3% and 85.7% of cases in younger and older than 40, retrospectively. Tongue was the most prevalent anatomic location of OSCC in both groups (39%). Based on clinicopathologic features, most prevalent pathologic degree of OSCC in younger aged patients was moderately differentiated OSCC (14.5%). In patients older than 40, well differentiated OSCC (87.7%) was more prevalent. Conclusion: Based on histopathologic features, the moderately differentiated and well differentiated OSCC were more in younger and older patients than 40, respectively. The finding suggests that OSCC has more malignant feature in young patients. Squamous cell carcinoma Oral cavity Prognosis 2018 6 01 49 51 http://jbrms.medilam.ac.ir/article-1-376-en.pdf 10.29252/jbrms.5.3.49
19-363 2024-03-29 10.1002
Journal of Basic Research in Medical Sciences 2383-0506 2383-0972 doi 2018 5 3 Expression of Toll-Like receptors in metabolic syndrome: A systematic review Manijeh Mahdavi manijeh.mahdavi@gmail.com Zahra Fallah z_fallah@mail.mui.ac.ir Roya Kelishadi kelishadi@med.mui.ac.ir Introduction: Toll-Like Receptors (TLRs) of innate immune system have documented roles in the pathogenesis of metabolic disorders. This study aims to systematically review the expression of TLRs on metabolic syndrome (MetS). Materials and methods: We systematically searched PubMed/Medline, ISI web of Science, Scopus, Google Scholar, EMBASE, and OVID databases until February 2017. The terms ‘‘Metabolic Syndrome’’ OR ‘‘Mets’’ AND ‘‘Toll like receptor’’ OR ‘‘Toll like’’ OR ‘‘TLRs’’ OR ‘‘TLR’’ were used. “Expression” advertently was not used in our search and was considered in the selection process. Three steps for selecting the articles and then their qualification were conducted. Results: First, 1373 articles were found in the international databases. After removing duplicates, 963 papers remained and after two steps of selection, this number reached 410 and then 27, respectively. After full text screening and qualifying processes, we finally included 13 articles consisting of five animal and eight human studies. All human studies reported overexpression of TLRs (types 2, 4, 5, 9) in MetS, and most animal studies documented an increased TLRs expression. Conclusion: This systematic review provides evidence for the relation of innate immune system with MetS. Its findings regarding overexpression of special TLRs (e.g. types 2, 4, 5, 9) in MetS and their basic mechanisms and clinical implications might be investigated in further studies. Metabolic Syndrome Toll-Like Receptors Chronic disease Inflammation 2018 6 01 52 56 http://jbrms.medilam.ac.ir/article-1-363-en.pdf 10.29252/jbrms.5.3.52