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:: Volume 4, Issue 1 (1-2017) ::
JBRMS 2017, 4(1): 8-16 Back to browse issues page
Effect of endurance exercise training on morphological changes in rat heart tissue following experimental myocardial infarction
Akbar Azamian Jazi , Hadi Abdi *, Mohammad Reza Haffezi Ahmadi , Javad Cheraghi
Associate professor Department of Physical Education, Payam-e-noor University, Tehran, Iran , azamianakbar@yahoo.com
Abstract:   (558 Views)

Introduction: Cardiac remodeling after myocardial infarction, is associated with progressive ventricular dysfunction and cardiovascular death. The purpose of this study was to examine the effect of endurance exercise training on morphological changes in rat heart tissue following experimental myocardial infarction.

Materials and methods: Rats used in this experiment (8-10 weeks old, 235 ± 5 g body weight) after homogenization according to body weight, were randomly divided to three groups: Healthy (Sham), control (Sedentary) and endurance training groups. Myocardial infarction was induced by subcutaneous injection of isoprenaline (150 mg/kg) in two consecutive days with an interval of 24 hours. Endurance training initiated 2 days after infarction and continued for 4 weeks. In order to assess the necrosis lesion and fibrosis tissue, Hematoxylin–Eosin and Masson's trichrome staining were used, respectively. Data were analyzed by using one-way analysis of variance (ANOVA) at P< 0.05 level.

Results: The results indicated that subcutaneous injection of isoprenaline, induced myocardial infarction in rat heart tissue. Rate of necrotic lesion in the Endurance training group was significantly higher than Sedentary (control) group (P=0.005).        Also, the size of fibrosis tissue in the Endurance training group was significantly higher than the sedentary         (control) group (P= 0.001).

Conclusion: In general, results of this study showed that 4 weeks of endurance exercise training after myocardial infarction exacerbate tissue injury in rat heart.

Keywords: Endurance training, Myocardial infarction, Morphological changes, Rat
Full-Text [PDF 822 kb]   (577 Downloads)    
Type of Study: Research | Subject: Cardiovascular Diseases
Received: 2015/05/24 | Accepted: 2015/07/26 | Published: 2016/07/6
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Azamian Jazi A, Abdi H, Haffezi Ahmadi M R, Cheraghi J. Effect of endurance exercise training on morphological changes in rat heart tissue following experimental myocardial infarction. JBRMS. 2017; 4 (1) :8-16
URL: http://jbrms.medilam.ac.ir/article-1-130-en.html


Volume 4, Issue 1 (1-2017) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
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