Introduction: Crimean Congo hemorrhagic fever (CCHF) is a Zoonosis disease. The aim of this study was to examine the effect of educational intervention on practice improvement of employees in healthcare centers and meat distribution centers of Ilam province in relation to Crimean Congo hemorrhagic fever.

Materials and methods: Participants in present quasi-experimental study were 200 employees of healthcare centers and 75 workers of meat distribution centers that were selected through simple random sampling. Data were collected at baseline and 6-weeks after intervention using two 38-item and 50-item questionnaires. Data were analyzed by the SPSS software. P<0.05 were considered to be statistically significant.

Results: Before the educational intervention, 20.6% of the healthcare centers employees had poor knowledge, 61.8% and 17.6% had average and good knowledge, respectively. After educational intervention, these percentages were 2%, 22.1% and 76% in that order. The workers’ knowledge level in centers of meat processing-distribution before training was 64% poor, 34.7% average, and 1.3% good but after education, the knowledge levels reached to 5.3%, 45.3% and 49.3% respectively (P<0.05). Moreover, Attitude of employees in healthcare centers and meat distribution centers significantly increased after intervention (P<0.05). But, there were not significant changes in performance of two groups before and after educational intervention

Conclusion: The results of present study showed the effect of educational intervention on improvement the knowledge, attitude of employees in healthcare and meat distribution centers. So, implementation of an educational program for employees at a wider scale could promote their health.