[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
About Journal::
Editorial Board::
Articles Archive::
Indexing Databases::
To Authors::
To Reviewers::
Registration::
Submit Your Article::
Policies and Publication Ethics::
Archiving Policy::
Site Facilities::
Contact Us::
::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019
Citations709570
h-index1110
i10-index1512
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Registered in

AWT IMAGE

AWT IMAGE

..
:: Volume 5, Issue 2 (3-2018) ::
2018, 5(2): 21-26 Back to browse issues page
Effects of static and electromagnetic fields on human serum paraoxonase-1 activity in vitro
Soheila Abdi
Department of Physics, Safadasht Branch, Islamic Azad University, Safadasht, Tehran, Iran , abdi.soheila@gmail.com
Abstract:   (4209 Views)
Introduction: In recent years the relationship between electromagnetic fields and coronary artery disease is attracted a considerable attention. Low density lipoprotein (LDL) oxidation is the initial step in the development of atherosclerosis. Paraoxonase1 (PON1) protects LDL and High density lipoprotein (HDL) against oxidative processes, thus preventing the formation of atherogenic (oxidized-LDL) ox-LDL molecules. In this study we investigated the effects of static magnetic fields (SMFs) and extremely low frequency electromagnetic fields (ELF-EMFs) on PON1 activity as one of the independent risk factors for cardiovascular disease.
Materials and methods: Pooled serum sample of 20 healthy men were exposed to SMFs and EMFs flux densities of 0.125, 0.25, 0.5, 1, 2, 3 and 4 mT for 60, 120 and 180 minutes at 25°C and then PON1 activity was measured spectrophotometrically using paraoxon as substrate.
Results: EMFs of 0.125-1 mT had no effect on PON1 activity. Exposure to magnetic flux density of 2 mT leads to a significant increase in PON1 activity in 1 hour (P <0.05). Magnetic flux density of 3 and 4 mT, after 1hour of exposure, lead to an increase of PON1 activity to 1.2% and 2.8%, respectively (P <0.01).
Conclusion: PON1 activity is influenced by a variety of agents like environmental, pharmacological, and lifestyle factors as well as age and sex. According to the finding of this study ELF-EMFs can alternate the serum activity of PON1 in vitro. If this effect of EMFs on PON1 activity has proven in vivo, it can be considered as an effective factor in coronary artery disease.
Keywords: Static magnetic field, Extremely low frequency electromagnetic field, Paroxonase-1
Full-Text [PDF 789 kb]   (1274 Downloads)    
Type of Study: Review Article | Subject: Medical physics
Received: 2017/11/23 | Accepted: 2018/01/10 | Published: 2018/02/8
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Abdi S. Effects of static and electromagnetic fields on human serum paraoxonase-1 activity in vitro. Journal of Basic Research in Medical Sciences 2018; 5 (2) :21-26
URL: http://jbrms.medilam.ac.ir/article-1-295-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 5, Issue 2 (3-2018) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
Persian site map - English site map - Created in 0.17 seconds with 41 queries by YEKTAWEB 4643