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:: Volume 6, Issue 4 (9-2019) ::
JBRMS 2019, 6(4): 20-28 Back to browse issues page
The effect of endurance training along with L-arginine supplementation on the levels of MMP-2 and MMP-9 in postmenopausal hypertensive women
Bita Bordbarazari , Mandana Gholami , Khosrow Ebrahim , Hossein Abed Natanzi , Farshad Ghazalian
Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran , m.gholami@srbiau.ac.ir
Abstract:   (58 Views)
Introduction: Matrix metalloproteinases (MMPs) including MMP2 and MMP9 play an important role in hypertension pathogenesis. The aim of present study was to identify the effect of endurance training along with L-arginine supplementation on the levels of MMP-2 and MMP-9 in postmenopausal hypertensive women. 
Materials and methods: The 40 postmenopausal hypertensive women’s (average age of 55.26 ± 2.56 years and BMI 28.61±1.18 kg/m2) randomly divided in four groups including placebo, L-arginine, endurance training and endurance training + L-arginine groups. Exercise training program conducted for 12 weeks with 60-75 percent of maximum heart rate. L-arginine consumption considered 6 g daily. Blood sampling performed in pre and posttest (48 hours after last training session or L-arginine consumption) stages and MMP2 and MMP9 were measured by ELISA method.
Results: Present study findings indicated that L-arginine, training and training + L-arginine result in significant decrease of MMP-2, MMP-9 and systolic blood pressure (P<0.05). Moreover, the greatest reduction in MMP-2 and MMP-9 levels and systolic blood pressure were observed in training + L-arginine group.
Conclusion: It seems that, L-arginine supplementation increases the antihypertensive effect of endurance training that partly related to decrease in MMP-2 and MMP-9 levels.
Keywords: Matrix metalloproteinase, L-arginine, Hypertension, Postmenopausal
Full-Text [PDF 551 kb]   (27 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2019/11/1 | Accepted: 2019/12/14
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Bordbarazari B, Gholami M, Ebrahim K, Abed Natanzi H, Ghazalian F. The effect of endurance training along with L-arginine supplementation on the levels of MMP-2 and MMP-9 in postmenopausal hypertensive women. JBRMS. 2019; 6 (4) :20-28
URL: http://jbrms.medilam.ac.ir/article-1-469-en.html


Volume 6, Issue 4 (9-2019) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
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