Journal of Basic Research in Medical Sciences
Volume 9, Issue 3 (6-2022)
jbrms 2022, 9(3): 23-30 |
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Masih Z, Hoghooghirad N, Madani R, Sharbatkhori M. Human Hydatid Cyst Zoonotic Characters and analysis of P29 Recombinant Protein Immunogenicity. jbrms 2022; 9 (3) :23-30
URL: http://jbrms.medilam.ac.ir/article-1-722-en.html
URL: http://jbrms.medilam.ac.ir/article-1-722-en.html
Department of Veterinary Parasitology, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran , hoghooghiradnasser@yahoo.com.
Abstract: (1359 Views)
Introduction: Echinococcosis or hydatid disease is one of the most important zoonosis across the world.
Materials and Methods: The recombinant P29 protein is considered as a suitable candidate for evaluating diagnostic ELISA to reach a more accurate conclusion.
Results: In this study the P29 sequence comprised with somewhat similar sequences registered in Gene Bank and showed 100% identity with P29 sequences derived from Echinococcus granolosus (E. granulosus) (XP_024351425.1), E. multilocularis (AHA85396.1), Endophilin B1 protein of E. granulosus (CDS21096.1). The primary and secondary structure of the peptide was analyzed due to its characterization of peptide motifs to be expressed on MHC Class HLA allels.
Conclusion: The recombinant P29 derived peptides can be produced and analyzed due to be determined as vaccine design candidate against Hydatidosis.
Materials and Methods: The recombinant P29 protein is considered as a suitable candidate for evaluating diagnostic ELISA to reach a more accurate conclusion.
Results: In this study the P29 sequence comprised with somewhat similar sequences registered in Gene Bank and showed 100% identity with P29 sequences derived from Echinococcus granolosus (E. granulosus) (XP_024351425.1), E. multilocularis (AHA85396.1), Endophilin B1 protein of E. granulosus (CDS21096.1). The primary and secondary structure of the peptide was analyzed due to its characterization of peptide motifs to be expressed on MHC Class HLA allels.
Conclusion: The recombinant P29 derived peptides can be produced and analyzed due to be determined as vaccine design candidate against Hydatidosis.
Type of Study: Review Article |
Subject:
Parasitologiy
Received: 2022/08/5 | Accepted: 2022/10/15 | Published: 2022/06/19
Received: 2022/08/5 | Accepted: 2022/10/15 | Published: 2022/06/19
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