Journal of Basic Research in Medical Sciences
J Basic Res Med Sci
Volume 13, Issue 3 (6-2026)
jbrms 2026, 13(3): 48-59 |
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Bastami M, Taghinezhad F, Azadi A, Heidarzadeh H, Nouri M, Pakseresht M. Comparison of Weaning Success from Mechanical Ventilation Using Heat and Moisture Exchangers (HME) and Humidifier in Intensive Care Unit (ICU) Patients: A Quasi-Experimental Study. jbrms 2026; 13 (3) :48-59
URL: http://jbrms.medilam.ac.ir/article-1-1061-en.html
URL: http://jbrms.medilam.ac.ir/article-1-1061-en.html
Mohammadreza Bastami 
, Fakhredin Taghinezhad , Arman Azadi , Hamid Heidarzadeh , Masoumeh Nouri , Maryam Pakseresht
, Fakhredin Taghinezhad , Arman Azadi , Hamid Heidarzadeh , Masoumeh Nouri , Maryam Pakseresht
Department of Nursing, Faculty of Nursing and Midwifery, Ilam University of Medical Sciences, Ilam, Iran , pakseresht-m@medilam.ac.ir
Abstract: (265 Views)
Introduction: Weaning a patient from mechanical ventilation is an important step in the treatment of patients admitted to the intensive care unit, the failure of which can be associated with adverse effects in patients. Thus, the present study was conducted with the aim of determining and comparing the success rate in the process of weaning a patient from mechanical ventilation using heat and moisture exchangers (HME) and a humidifier in patients admitted to the intensive care unit (ICU).
Materials & Methods: In this quasi-experimental study, 40 patients treated with mechanical ventilation in the intensive care unit of hospitals of Ilam (Iran) were evaluated by random sampling in two intervention groups of 20 with HME and humidifier filters. In the first group, humidification of inhaled air was used using a humidifier filter, and in the second group, an HME filter was used to humidify inhaled air. Data related to the process of weaning patients from mechanical ventilation before and after the intervention were recorded in a checklist and analyzed by STATA V.12 using descriptive and inferential statistical tests in the significance less than 0.05.
Results: The rate of successful weaning was higher in the humidifier group (65%) compared with the HME group (40%), whereas weaning failure occurred in 35% and 60% of patients, respectively. Patients in the humidifier group showed a lower rate of weaning failure compared with the HME group; however, this association was not statistically significant in the adjusted analysis (OR = 0.40, P = 0.23). The PaO2/FiO2 ratio measured 30 minutes before weaning from mechanical ventilation was significantly associated with successful weaning (P = 0.003), such that each unit increase in this ratio reduced the odds of weaning failure by 3%.
Conclusion: Given the higher success rate of the humidifier filter compared to the HME in weaning patients from mechanical ventilation, the humidifier filter may be considered as a potential option for weaning from mechanical ventilation in patients admitted to the intensive care unit, though further research is needed to confirm its efficacy
Materials & Methods: In this quasi-experimental study, 40 patients treated with mechanical ventilation in the intensive care unit of hospitals of Ilam (Iran) were evaluated by random sampling in two intervention groups of 20 with HME and humidifier filters. In the first group, humidification of inhaled air was used using a humidifier filter, and in the second group, an HME filter was used to humidify inhaled air. Data related to the process of weaning patients from mechanical ventilation before and after the intervention were recorded in a checklist and analyzed by STATA V.12 using descriptive and inferential statistical tests in the significance less than 0.05.
Results: The rate of successful weaning was higher in the humidifier group (65%) compared with the HME group (40%), whereas weaning failure occurred in 35% and 60% of patients, respectively. Patients in the humidifier group showed a lower rate of weaning failure compared with the HME group; however, this association was not statistically significant in the adjusted analysis (OR = 0.40, P = 0.23). The PaO2/FiO2 ratio measured 30 minutes before weaning from mechanical ventilation was significantly associated with successful weaning (P = 0.003), such that each unit increase in this ratio reduced the odds of weaning failure by 3%.
Conclusion: Given the higher success rate of the humidifier filter compared to the HME in weaning patients from mechanical ventilation, the humidifier filter may be considered as a potential option for weaning from mechanical ventilation in patients admitted to the intensive care unit, though further research is needed to confirm its efficacy
Keywords: Success, Weaning, Mechanical Ventilation, Patient, Heat and Moisture Exchangers (HME), Humidifier
Type of Study: Research |
Subject:
Internal medicine
Received: 2025/12/6 | Accepted: 2026/02/24 | Published: 2026/06/16
Received: 2025/12/6 | Accepted: 2026/02/24 | Published: 2026/06/16
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