Introduction: Long-term complications of diabetes leads to physical and mental weakness and reduce their quality of life. One of the complications is the chronic wounds of extremities. Because of its outcome, patient’s adaptation can be reduced. The aim of this study was to compare depression between diabetic patients with and without foot wounds.

Materials and methods: The comparative-descriptive study was performed on diabetic patients with and without foot wounds that admitted to the hospitals in Qom University of Medical Sciences in 2014. 100 patients with chronic wounds and 100 patients without the wounds was recruited by available sampling method for the study. We employed the “Demographic and clinical” and "Beck depression" questionnaires for gathering the data. The study data were analyzed by independent t and Chi-square tests using the SPSS (version 13) statistical software.

Results: Mean and standard deviation of age in patient with and without chronic wound was 52.1±3.9 and 51.5±4.1 years, respectively. Depressive score of patient with and without chronic wound was also 25.6±9.5 and 8.7±2.1, respectively. Depression score of patient with underlying disease was higher than patients without underlying disease. The depression score rises with age. The depression scores were similar in both male and female gender.