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:: Volume 4, Issue 2 (3-2017) ::
2017, 4(2): 17-23 Back to browse issues page
Functional recovery assessment of spinal cord contusion model in male rats without therapeutic interventions
Sara Rezaei , Salar Bakhtiari , Khairollah Asadollahi , Somayeh Heidarizadi , Ardeshir Moayeri , Monireh Azizi
Department of Anatomy, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran , moayeri46@yahoo.com
Abstract:   (4203 Views)

Introduction: Spinal cord injury (SCI) is one of the most serious clinical diseases, which not only affects the patient's physical and mental status, but its effects will be spread to family and community. After severe spinal cord injury, astrocytes of the central nervous system (CNS) become reactive astrocytes, and play the main role of glial scar formation. The scar is a major obstacle to regeneration of axons in the spinal cord. However, the studies have found that over time, a spontaneous partial motor recovery is observed in animals with injury without intervention. Thus, in this study, the recovery of animals with spinal cord injury was assessed after 12 weeks.

Materials and methods: In this study, 12 adult male Wistar rats weighing approximately   265±15gr were used to assess spinal cord injury and randomly divided into 3 groups: normal control (n = 3), sham (n = 3), injury (n = 6). Healthy animals in the normal control group received no laminectomy or injury, and laminectomy with or without contusion model using weight drop in segment T10 of spinal cord were carried out in injury and sham groups, respectively. Locomotor function of animals in all groups were evaluated by BBB test at the first 48 hours per day and then weekly for 12 weeks.

Results: Comparison of the results of motor evaluation from the second week to the twelfth week of the group with injury without treatment showed a relative functional recovery as the BBB score of animals from 1.4 in the second week after the injury reached to 6.5 in the twelfth week.

Conclusion: The results indicate a spontaneous partial recovery in injured animals without intervention.

Keywords: Spinal cord injury, Glial scar, Functional recovery, Rat
Full-Text [PDF 574 kb]   (1566 Downloads)    
Type of Study: Research | Subject: Medical Anatomy
Received: 2016/03/25 | Accepted: 2016/08/8 | Published: 2016/09/15
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Rezaei S, Bakhtiari S, Asadollahi K, Heidarizadi S, Moayeri A, Azizi M. Functional recovery assessment of spinal cord contusion model in male rats without therapeutic interventions. Journal of Basic Research in Medical Sciences 2017; 4 (2) :17-23
URL: http://jbrms.medilam.ac.ir/article-1-193-en.html

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Volume 4, Issue 2 (3-2017) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
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