[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
About Journal::
Editorial Board::
Articles Archive::
Indexing Databases::
To Authors::
To Reviewers::
Submit Your Article::
Policies and Publication Ethics::
Archiving Policy::
Site Facilities::
Contact Us::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
Registered in



:: Volume 3, Issue 1 (1-2016) ::
2016, 3(1): 39-44 Back to browse issues page
The effect of rehabilitation training on TRF1 and TRF2 in myocardial infarction patients
Behzad Saki , Khosro Ebrahim , Amir Hossein Abedy Yekta
Department of Physical Education and Sports Sciences, Shahid Beheshti University, Tehran, Iran , b_saki@sbu.ac.ir
Abstract:   (4270 Views)

Introduction: Telomeres are repetitive sequences of TTAGGG section that find at two ends of eukaryotic chromosomes and they shield chromosome ends. Telomere shortening in patients with myocardial infarction has been reported. Shelterin complex's role is essential in telomere length regulation. Telomeric repeat binding factors 1 and 2 (TRF1 and TRF2) are the most important sheltrein complex proteins. The purpose of this study was to investigate the effect of eight weeks of rehabilitation training on TRF1 and TRF2 in myocardial infarction patients.

Materials and methods: In this Quasi-experimental pre-post intervention study, twenty male patients selected and randomly assigned to training (n=10) or control (n=10) groups. Rehabilitation training was eight weeks of concurrent training, 3 time per week. For TRF1 and TRF2 assessment, blood samples was taken half hour before first training session and 24 hours after the last training session. t-test was used for data analyses. Statistical significance was set at P<0.05.

Results: The findings of the present study revealed that concurrent training increases TRF1 and TRF2 protein levels significantly (P=0.005 and P=0.006, respectively).

Conclusion: It seems that rehabilitation training improves shelterin complex and enhances protection of the telomere and as a result, induces better repair of infarcted area. Therefore, rehabilitation training could be suggested to myocardial infarction patients as a non-pharmacological treatment.

Keywords: Rehabilitation training, TRF1, TRF2, Myocardial infarction, Telomere
Full-Text [PDF 595 kb]   (1316 Downloads)    
Type of Study: Research | Subject: Cardiovascular Diseases
Received: 2015/08/16 | Accepted: 2015/11/29 | Published: 2015/12/2
Send email to the article author

Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Saki B, Ebrahim K, Abedy Yekta A H. The effect of rehabilitation training on TRF1 and TRF2 in myocardial infarction patients. Journal of Basic Research in Medical Sciences 2016; 3 (1) :39-44
URL: http://jbrms.medilam.ac.ir/article-1-211-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 3, Issue 1 (1-2016) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
Persian site map - English site map - Created in 0.16 seconds with 41 queries by YEKTAWEB 4654