[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 4, Issue 4 (9-2017) ::
JBRMS 2017, 4(4): 8-12 Back to browse issues page
Evaluation of PPP2R5C gene expression in Iranian patients with B-Acute lymphoblastic leukemia and its association with clinical and laboratory findings
Esmaeil Rostami, Hossein Ayatollahi, Hassan Boustani, Abbas Ghotaslou, Mohammad Hadi Sadeghian, Mohammad Reza Keramati, Elahe Zeinali, Abolfazl Rad
Department of Hematology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran , a.ghotaslou@gmail.com
Abstract:   (3947 Views)

Introduction: PPP2R5C is one of the regulatory B subunits of protein phosphatase 2A (PP2A), which is a tumor suppressor. PPP2R5C plays a critical role in cell proliferation, differentiation, and transformation. Considering these vital functions, we investigate the gene expression in Iranian patients with B-Acute Lymphoblastic Leukemia (B-ALL) and its association with clinical and laboratory finding.

Materials and methods: In this case-control study, peripheral blood samples were collected from 60 B-ALL patients and 30 healthy controls. PPP2R5C expression levels were determined by Real-time PCR. After calculation of CT for target and control genes, we calculated ΔCT. Finally we compared the PPP2R5C expression levels in patients with control group.

Results: Significantly higher expression of PPP2R5C was found in the B-ALL patients (2.15±2. 50) compared with control group. There was no correlation between PPP2R5C expression and clinical and laboratory findings and FAB (French-American-British) subtype of patients.

Conclusion: we demonstrated PPP2R5C overexpression in B-ALL patients. Although there was no significant correlation between PPP2R5C expression, clinical and laboratory finding and also with FAB subtypes of patients.

Keywords: B-Acute Lymphoblastic Leukemia, PPP2R5C, PP2A, Gene expression
Full-Text [PDF 635 kb]   (1147 Downloads)    
Type of Study: Research | Subject: Hematology
Received: 2017/02/22 | Accepted: 2017/04/21 | Published: 2017/06/15
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rostami E, Ayatollahi H, Boustani H, Ghotaslou A, Sadeghian M H, Keramati M R, et al . Evaluation of PPP2R5C gene expression in Iranian patients with B-Acute lymphoblastic leukemia and its association with clinical and laboratory findings . JBRMS 2017; 4 (4) :8-12
URL: http://jbrms.medilam.ac.ir/article-1-287-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 4, Issue 4 (9-2017) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
Persian site map - English site map - Created in 0.5 seconds with 30 queries by YEKTAWEB 4514