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:: Volume 5, Issue 3 (6-2018) ::
2018, 5(3): 42-48 Back to browse issues page
Comparison of high-intensity interval versus low-intensity continuous training for myelin synthesis related genes in C57BL/6 mice
Maryam Naghibzadeh , Rouhollah Ranjbar , Mohammad Reza Tabandeh , Abdolhamid Habibi , Zohreh Ghotbeddin
Department of Physical Education and Sports Science, Faculty of Literature and Humanities, Ilam University, Ilam, Iran , naghibzadehmaryam@yahoo.com
Abstract:   (3996 Views)
Introduction: By increasing the scientific focus on myelination, identifying factors that influence the myelination is an important goal for brain health. There are some studies that regular exercise improves myelin sheath and neuronal regeneration. However, the effects of exercise intensities on the myelination remain unclear. Therefore, the purpose of this study was to compare the effect of high-intensity interval (HIIT) versus low-intensity continuous training (LICT) on myelin synthesis-related genes in hippocampus of C57BL/6 mice.
Materials and methods: Male C57BL/6 mice (n = 30) were randomly assigned to 3 groups: control (C), Interval training (IT), and Continuous training (CT). Training programs on the treadmill were performed for 8 weeks and then, the hippocampus of animals was analyzed for the expression of myelin basic protein (MBP) and proteolipid protein (PLP) genes. Data were analyzed using ANOVA.
Results: The result showed that HIIT program significantly increased the mRNA levels of MBP and PLP in comparison with LICT and Control groups (P<0.05), while no significant differences were observed among the LICT and Control groups (P>0.05).
Conclusion: Our results showed that HIIT had a more efficient by improving the expression of MBP and PLP genes compared to LICT in the hippocampus.
Keywords: Interval training, Continuous training, Myelin basic protein, Proteolipid protein, Hippocampus
Full-Text [PDF 777 kb]   (1186 Downloads)    
Type of Study: Research | Subject: Medical physics
Received: 2018/03/12 | Accepted: 2018/07/19 | Published: 2018/09/4
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Naghibzadeh M, Ranjbar R, Tabandeh M R, Habibi A, Ghotbeddin Z. Comparison of high-intensity interval versus low-intensity continuous training for myelin synthesis related genes in C57BL/6 mice. Journal of Basic Research in Medical Sciences 2018; 5 (3) :42-48
URL: http://jbrms.medilam.ac.ir/article-1-368-en.html

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Volume 5, Issue 3 (6-2018) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
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