The purpose of the present study was to investigate the context of lipid metabolism research in physical activity, lipolysis, lipolysis hormone regulation and the fate of lipolysis products in exercise, fatty acid transporters, some genes involved in lipid metabolism, effect of resistance activity on lipolysis, adaptations of adipose tissue due to physical activity, lipoproteins and apoproteins and the effect of physical activity and to achieve a desirable conclusion and provide more relevant information from previous research. In this study, articles were searched in specialized databases and 40 related articles were selected based on inclusion and exclusion criteria, and the molecular adaptations of lipolysis to physical activity were investigated.
The amount of free fatty acid occurrence can be measured by estimating the amount of lipolysis. Fatty acids released from adipose tissue lipolysis form a major part of the active fuel, especially when the duration of training is long and the intensity is low to moderate. Physical activity through the release of more epinephrine from the adrenal glands and norepinephrine from the sympathetic nerve endings increases the rate of lipolysis of adipose tissue.  Also, aerobic activity increases the genes involved in lipid metabolism and lipolysis.
The present study showed that the intensity and duration of training, diet and training positions influence lipolysis and lipid metabolism. The amount of adipose tissue lipolysis is controlled by triacylglycerol hormone-sensitive lipase. Resistance activity stimulates stimulating growth hormone, catecholamines, and enzymes involved in the lipolysis process. Endurance training also reduces the number of fat cells and reduces plasma triacylglycerol concentrations.