[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
About Journal::
Editorial Board::
Articles Archive::
Indexing Databases::
To Authors::
To Reviewers::
Submit Your Article::
Policies and Publication Ethics::
Archiving Policy::
Site Facilities::
Contact Us::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
Registered in



:: Volume 7, Issue 2 (3-2020) ::
2020, 7(2): 1-6 Back to browse issues page
Distinctive deregulation of miR-27a and miR-27b in relapsing remitting multiple sclerosis
Jalil Shafiei , Farideh Heidari , Elham Khashen , Rana Ghandehari‐Alavijeh , Zahra Darmishonnejad
Department of Genetic, Science and Research Branch, Islamic Azad University, Tehran, Iran , Jalilshafiei20@gmail.com
Abstract:   (2152 Views)
Introduction: Previous studies have proposed that microRNAs (miRNAs) expression might be responsible for immunological features associated with multiple sclerosis (MS) pathogenesis. We aimed to elucidate the alternation in miR-27a and miR-27b expression in relapsing-remitting multiple sclerosis (RRMS) patients compared to the healthy subjects.
Materials and methods: In this study, the expression levels of miR-27a and miR-27b were evaluated in peripheral blood samples of 60 RRMS patients (30 recurrence patients and 30 patients two months after relapse) and 30 healthy subjects by quantitative real-time PCR.
Results: The findings indicated that the expression of miR-27a was significantly decreased in recurring patients (P<0.0001) and two months after relapse patients (P<0.003) in comparison with healthy subjects. Moreover, miR-27b showed down regulation in recurring patients (P<0.001) and two months after relapse patients (P<0.002).
Conclusion: The results demonstrated an association between expression of miRNAs studied and RRMS disease during recurrence and two months after relapse. However, further research is warranted to confirm observed associations.
Keywords: microRNA, miR-27a, miR-27b, Multiple sclerosis
Full-Text [PDF 793 kb]   (914 Downloads)    
Type of Study: Research | Subject: Genetics
Received: 2020/02/16 | Accepted: 2020/04/17 | Published: 2020/06/6
Send email to the article author

Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Shafiei J, Heidari F, Khashen E, Ghandehari‐Alavijeh R, Darmishonnejad Z. Distinctive deregulation of miR-27a and miR-27b in relapsing remitting multiple sclerosis. Journal of Basic Research in Medical Sciences 2020; 7 (2) :1-6
URL: http://jbrms.medilam.ac.ir/article-1-480-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 7, Issue 2 (3-2020) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
Persian site map - English site map - Created in 0.16 seconds with 41 queries by YEKTAWEB 4654