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:: Volume 9, Issue 1 (1-2022) ::
2022, 9(1): 19-30 Back to browse issues page
Preconditioning by the exercise and curcumin protects left ventricular myocardium against ischemia-reperfusion injury and suppresses ventricular arrhythmias in rats
Zahra Sayevand , Farzad Nazen , Afshin Nazari
Department of Sport Physiology, Section of Health Science, Faculty of Physical Education and Sport Sciences, Bu-Ali Sina University, Hamedan, Iran , farzadnazem2@gmail.com
Abstract:   (1490 Views)
Introduction: The present study examined the effects of a 10-week preconditioning with moderate-intensity aerobic exercise and curcumin supplementation before ischemia-reperfusion (IR) to investigate if this method contributes to the protection of cardiac myocardium against IR-induced injury and left ventricular dysfunction in rat.
Materials and Methods: Male Wistar rats (6-8 weeks old) were randomly assigned to the 5 groups (each with 10 rats), sedentary-control (Sed-CON), sedentary ischemia-reperfusion (Sed-IR), exercise with IR (Ex-IR), curcumin with IR (Cu-IR), and both exercise and curcumin with IR (Ex-Cu-IR). Exercise intervention performed five times a week for 10 weeks. After the training period, arrhythmias and electrocardiogram parameters, factors involved in cardiac structure and function, and infarct size of myocardium were investigated.
Results: We observed that a 10-week moderate-intensity aerobic exercise (15-45 min at 12-24 m/min) five sessions a week as well as curcumin supplementation (50 mg/kg) over the mentioned period, in advance to IR, significantly decreased IR-induced infarct size in Ex-IR, Cu-IR, and Ex-Cu-IR groups compared to Sed-IR (P = 0.0001), alleviated arrhythmia by reduction in ventricular ectopic beats episodes in Ex-IR, Cu-IR, and Ex-Cu-IR groups compared to Sed-IR (P = 0.001), decreased ventricular tachycardia episods in Ex-IR, Cu-IR, and Ex-Cu-IR groups in comparison to that of Sed-IR group (P = 0.001) and improved cardiac function (P = 0.001).
Conclusion: According to our findings, exercise has superior cardioprotective effects than curcumin. The combination of curcumin and exercise has no preference on exercise or curcumin alone. Hence both long-term aerobic exercise and curcumin supplementation are effective cardioprotectors against IR-induced injury.
Introduction: The present study examined the effects of a 10-week preconditioning with moderate-intensity aerobic exercise and curcumin supplementation before ischemia-reperfusion (IR) to investigate if this method contributes to the protection of cardiac myocardium against IR-induced injury and left ventricular dysfunction in rat.
Materials and Methods: Male Wistar rats (6-8 weeks old) were randomly assigned to the 5 groups (each with 10 rats), sedentary-control (Sed-CON), sedentary ischemia-reperfusion (Sed-IR), exercise with IR (Ex-IR), curcumin with IR (Cu-IR), and both exercise and curcumin with IR (Ex-Cu-IR). Exercise intervention performed five times a week for 10 weeks. After the training period, arrhythmias and electrocardiogram parameters, factors involved in cardiac structure and function, and infarct size of myocardium were investigated.
Results: We observed that a 10-week moderate-intensity aerobic exercise (15-45 min at 12-24 m/min) five sessions a week as well as curcumin supplementation (50 mg/kg) over the mentioned period, in advance to IR, significantly decreased IR-induced infarct size in Ex-IR, Cu-IR, and Ex-Cu-IR groups compared to Sed-IR (P = 0.0001), alleviated arrhythmia by reduction in ventricular ectopic beats episodes in Ex-IR, Cu-IR, and Ex-Cu-IR groups compared to Sed-IR (P = 0.001), decreased ventricular tachycardia episods in Ex-IR, Cu-IR, and Ex-Cu-IR groups in comparison to that of Sed-IR group (P = 0.001) and improved cardiac function (P = 0.001).
Conclusion: According to our findings, exercise has superior cardioprotective effects than curcumin. The combination of curcumin and exercise has no preference on exercise or curcumin alone. Hence both long-term aerobic exercise and curcumin supplementation are effective cardioprotectors against IR-induced injury.
Keywords: Antiarrhythmic herbs, Cardioprotection, Moderate-intensity exercise, Reoxygenation injury, Cardiovascular disease
Full-Text [PDF 345 kb]   (406 Downloads)    
Type of Study: Research | Subject: Cardiovascular Diseases
Received: 2021/05/24 | Accepted: 2021/08/26 | Published: 2022/01/11
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Sayevand Z, Nazen F, Nazari A. Preconditioning by the exercise and curcumin protects left ventricular myocardium against ischemia-reperfusion injury and suppresses ventricular arrhythmias in rats. Journal of Basic Research in Medical Sciences 2022; 9 (1) :19-30
URL: http://jbrms.medilam.ac.ir/article-1-608-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 9, Issue 1 (1-2022) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
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