[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
About Journal::
Editorial Board::
Articles Archive::
Indexing Databases::
To Authors::
To Reviewers::
Registration::
Submit Your Article::
Policies and Publication Ethics::
Archiving Policy::
Site Facilities::
Contact Us::
::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019
Citations740600
h-index1110
i10-index1513
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Registered in

AWT IMAGE

AWT IMAGE

..
:: Volume 10, Issue 1 (1-2023) ::
2023, 10(1): 38-48 Back to browse issues page
Comparison of HIF1 gene polymorphism (rs11549465) among elite and amateur karate-kas versus non-athletes
Mohammad Reza Batavani , Sayyed Mohammad Marandi , Kamran Ghaedi , Mojtaba Babaei Khorzoghi , Neda Boroushak
Faculty of Center of Physical Education, Isfahan University of Technology, Isfahan 84156-83111, Iran , batavani@iut.ac.ir
Abstract:   (343 Views)
Introduction: One of the major energy systems for power performance in muscles is glycolysis that is regulated by the levels of Hypoxia-inducible factor-1α (HIF1), which acts as a transcription factor in response to hypoxia. The purpose of this study was to compare the HIF1 gene polymorphism (rs11549465) between elite and amateur power karate-kas versus non-athletes.
Materials and Methods: In this survey, the C/T polymorphism allelic and genotypic distribution of the “HIF1 rs11549465” gene was detected in 550 healthy Iranian persons who were divided into three groups: elite karate-kas (86 males and 86 females) and amateur karate-kas (100 males and 72 females) versus 206 non-athletes (100 males and 106 females).  5 cc blood was taken for DNA extraction and the HIF1 gene T/C polymorphism was determined by PCR from the extracted DNA. Also, RFLP analyses was exerted by electrophoresis separation. Statistical analyses included Chi-Square and multinomial regression tests and data with P < 0.05 were considered to be a significant amount.
Results: The distribution of HIF1 C/T genotype in the groups was significantly different in all of subjects (TC: 25.6%; TT: 11.4% and CC: 63%) (χ2 = 99.889, P = 0.0001), but it was not different between the groups significantly (P > 0.05). Furthermore, multiple regression analysis demonstrated that the genotype of HIF1 was not related to the karate-ka's athletic status.
Conclusion: In Iranian population, the HIF1 gene C/T polymorphism is not related to the karate-ka athletic status.
 
Keywords: HIF1 protein, Polymorphism, Karate, Elite
Full-Text [PDF 386 kb]   (120 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2022/09/30 | Accepted: 2023/02/27 | Published: 2023/01/10
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Batavani M R, Marandi S M, Ghaedi K, Babaei Khorzoghi M, Boroushak N. Comparison of HIF1 gene polymorphism (rs11549465) among elite and amateur karate-kas versus non-athletes. Journal of Basic Research in Medical Sciences 2023; 10 (1) :38-48
URL: http://jbrms.medilam.ac.ir/article-1-720-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 10, Issue 1 (1-2023) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
Persian site map - English site map - Created in 0.16 seconds with 41 queries by YEKTAWEB 4653