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:: Volume 11, Issue 3 (6-2024) ::
2024, 11(3): 56-65 Back to browse issues page
The Impact of Specific Physical Training on FGF-2 and VEGF-A Expression in Patients Post-Coronary Artery Bypass Surgery
Maryam Monjezi , Alireza Barari , Ahmad Abdi
& 1 Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran , alireza54.barari@gmail.com
Abstract:   (172 Views)
Introduction:  Coronary artery bypass surgery (CABG) is a common procedure for patients with coronary artery disease. This study aimed to investigate the effect of selected physical exercises on the expression of FGF-2 and VEGF-A in patients post-CABG.
Material & Methods: In this semi-experimental study, 20 male patients from Afshar Hospital (Yazd City) who had undergone CABG were selected and randomly divided into two groups: a combined training group and a control group. The combined training group performed an 8-week program consisting of endurance training (15-20 minutes at 50-60% of HRmax) and resistance training (10-20 minutes, including three upper limb and two lower limb movements, each with three sets of 10 repetitions at 30-60% of 1RM), conducted three times per week. Gene expression of Fibroblast Growth Factor 2 (FGF-2) and Vascular Endothelial Growth Factor A (VEGF-A) was measured using Real-Time PCR. Data were analyzed using paired t-tests and one-way ANOVA with a significance level set at P<0.05.
Results: An increase in the expression of VEGF and FGF-2 genes was observed in the combined training group post-test compared to pre-test (p=0.019). Additionally, there was a significant difference in VEGF gene expression between the control and training groups (p=0.016). Significant differences were also found in FGF-2 expression between the combined exercise group and both the healthy control and patient control groups (p=0.001 for both).
 
Conclusion: The results suggest that combined exercises may enhance physiological adaptations and improve the functional capacity of the heart and vessels in CABG patients by increasing growth factor expression.

 
Keywords: The results suggest that combined exercises may enhance physiological adaptations and improve the functional capacity of the heart and vessels in CABG patients by increasing growth factor expression.
Full-Text [PDF 1376 kb]   (26 Downloads)    
Type of Study: Research | Subject: Public health
Received: 2023/05/30 | Accepted: 2023/06/8 | Published: 2024/06/21
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Monjezi M, Barari A, Abdi A. The Impact of Specific Physical Training on FGF-2 and VEGF-A Expression in Patients Post-Coronary Artery Bypass Surgery. Journal of Basic Research in Medical Sciences 2024; 11 (3) :56-65
URL: http://jbrms.medilam.ac.ir/article-1-760-en.html


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Volume 11, Issue 3 (6-2024) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
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