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:: Volume 11, Issue 2 (4-2024) ::
2024, 11(2): 53-61 Back to browse issues page
Effects of Lavandula Angustifolia Hydroalcoholic Extract on the Blood and Urine Biochemical Factors of Diabetic Patients: A Placebo-Controlled Clinical Trial
Leila Mahmoodnia , Zahra Forouzandeh Shahrakei , Sanaz Hojatyar , Mahbubeh Setorki
Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran , Doctor.setorgi@gmail. com
Abstract:   (454 Views)
Introduction: Diabetes mellitus remains one of the most prevalent metabolic diseases and a major health concern, despite the availability of a variety of synthetic drugs for its treatment. The multiple consequences of this disease, combined with the potential side effects of chemical treatments, led to the study of other therapies, such as the use of medicinal plants renowned for a variety of active components. Given the historic usage of medicinal plants for diabetes treatment, the aim of this study was to investigate the impact of lavender (Lavandula officinalis) hydroalcoholic extract on specific blood and urine biochemical factors in diabetic patients.
Material & Methods: In this double-blinding clinical trial, a total of 72 diabetes patients were divided into two groups: a control group that received a placebo and a treatment group that received the lavender hydroalcoholic extract. Capsules containing the lavender extract were formulated to be administered. The placebo capsules were given to the control group, while the lavender extract capsules were given to the treatment group twice a day, once in the morning and once at night, for two months. All patients underwent blood biochemical testing and urine analysis at the beginning and end of the trial. The data collected were analyzed using the SPSS 18 software.
Results: Compared to the placebo group, the mean HDL-C increased and the average levels of FBS, LDL-C, VLDL-C, TG, Chol, AST, and ALT became significantly lower (P < 0.05) in the patients who received capsules containing lavender extract. Likewise, the urine protein and sugar levels in the patients who received the lavender extract group were significantly lower (P < 0.05) compared to the control group. Yet, the average changes in BMI did not differ significantly between the groups receiving lavender extract and the placebo (P > 0.05).
Conclusion:  The lavender plant with different phenolic and flavonoids compounds could reduce blood sugar and also improve lipid profile in people with diabetes.
Keywords: Diabetes Mellitus, Lavandula, Plant Extracts
Full-Text [PDF 1710 kb]   (103 Downloads)    
Type of Study: Research | Subject: Clinical Biochemistry
Received: 2023/10/15 | Accepted: 2024/04/14 | Published: 2024/04/22
References
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2. Aju B, Rajalakshmi R, Mini S. Protective role of Moringa oleifera leaf extract on cardiac antioxidant status and lipid peroxidation in streptozotocin induced diabetic rats. Heliyon. 2019 Dec 4;5(12):e02935. doi: 10.1016/j.heliyon.2019.e02935. eCollection 2019 Dec.
3. Esteghamati A, Larijani B, Aghajani MH, Ghaemi F, Kermanchi J, Shahrami A, et al. Diabetes in Iran: prospective analysis from first nationwide diabetes report of National Program for Prevention and Control of Diabetes (NPPCD-2016). Sci Rep. 2017 Oct 18;7(1):13461. doi: 10.1038/s41598-017-13379-z.
4. Alberti K, Zimmet P. Definition, diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation. Diabet Med. 1998 Jul;15(7):539-53. doi: 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S.
5. Association AD. Summary of Revisions: Standards of Medical Care in Diabetes—2019. Diabetes Care 2019;42(Supplement1):S4–S6.
6. Rabiei Z, Rafieian-Kopaei M. Neuroprotective effect of pretreatment with Lavandula officinalis ethanolic extract on blood-brain barrier permeability in a rat stroke model. Asian Pac J Trop Med. 2014 Sep:7S1:S421-6. doi: 10.1016/S1995-7645(14)60269-8.
7. Sebai H, Selmi S, Rtibi K, Souli A, Gharbi N, Sakly M. Lavender (Lavandula stoechas L.) essential oils attenuate hyperglycemia and protect against oxidative stress in alloxan-induced diabetic rats. Lipids Health Dis. 2013 Dec 28;12:189. doi: 10.1186/1476-511X-12-189.
8. Prusinowska R, Śmigielski KB. Composition, biological properties and therapeutic effects of lavender (Lavandula angustifolia L). A review. Herba Pol. 2014;60(2):56-66. doi:10.2478/hepo-2014-0010.
9. Gray AM, Flatt PR. Insulin-releasing and insulin-like activity of the traditional anti-diabetic plant Coriandrum sativum (coriander). Br J Nutr. 1999 Mar;81(3):203-9. doi: 10.1017/s0007114599000392.
10. Pushparaj PN, Tan BK, Tan CH. The mechanism of hypoglycemic action of the semi-purified fractions of Averrhoa bilimbi in streptozotocin-diabetic rats. Life Sci. 2001 Dec 21;70(5):535-47. doi: 10.1016/s0024-3205(01)01423-0.
11. Patel D, Prasad SK, Kumar R, Hemalatha S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac J Trop Biomed. 2012 Apr;2(4):320-30. doi: 10.1016/S2221-1691(12)60032-X.
12. Rabiei Z, Rafieian-Kopaei M, Mokhtari S, Shahrani M. Effect of dietary ethanolic extract of Lavandula officinalis on serum lipids profile in rats. Iran J Pharm Res. 2014;13(4):1295. PMID: 25587318.
13. Nasri H, Rafieian-kopaei M, Shirzad M, Rafieian M, Sahinfard N, Rafieian S. Effects of Allium sativum on liver enzymes and atherosclerotic risk factors. J Herb Med Pharmacol. 2013.
14. Nasri H, Rafieian-Kopaei M. Oxidative stress and aging prevention. J Res Med Sci. 2015 May; 20(5): 491–502.doi: 10.4103/1735-1995.163977.
15. Asgary S, Sahebkar A, Afshani MR, Keshvari M, Haghjooyjavanmard S, Rafieian‐Kopaei M. Clinical evaluation of blood pressure lowering, endothelial function improving, hypolipidemic and anti‐inflammatory effects of pomegranate juice in hypertensive subjects. Phytother Res. 2014 Feb;28(2):193-9. doi: 10.1002/ptr.4977.
16. Torabzadeh P, Saffari S, Soheili F. Effects of aqueous extract of lavender (Lavandula officinalis) on the liver tissue and blood fat in Balb/C adult female mice. Clin Inves Arterio . 2017 Jan 1;7(2):1456-61.
17. Rafieian-Kopaei M, Baradaran A, Rafieian M. Oxidative stress and the paradoxical effects of antioxidants. J Res Med Sci. 2013 Jul; 18(7): 629. PMID: 24516501
18. Saei H, Azarmi M, Dehghan G, Zehtab Salmasi S, Zeinali S. Hepatoprotective Effect of Ethanolic Extract of Lavandula officinalis L. in Alloxan-Induced Diabetic Rats. Thrita. 2016;5(2):e35306. [DOI:10.5812/thritaj.35306.]
19. Al-Azzawie HF, Alhamdani M-SS. Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits. Life Sci. 2006 Feb 16;78(12):1371-7. doi: 10.1016/j.lfs.2005.07.029. Epub 2005 Oct 19.
20. Azarmi M, Saei H, Zehtab Salmasi S, Dehghan G. Investigating the treatable effect of Lavandula officinalis L. Ethanolic extract in alloxan-induced male diabetic rats. Pharmacologyonline. 2016;1:53-63. doi::10.1040/15376516.2019.1567892.
21. Group NDD. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 1979 Dec;28(12):1039-57. doi: 10.2337/diab.28.12.1039.
22. Aju B, Rajalakshmi R, Mini S. Protective role of Moringa oleifera leaf extract on cardiac antioxidant status and lipid peroxidation in streptozotocin induced diabetic rats. Heliyon. 2019 Dec 4;5(12):e02935. doi: 10.1016/j.heliyon.2019.e02935. eCollection 2019 Dec.
23. Esteghamati A, Larijani B, Aghajani MH, Ghaemi F, Kermanchi J, Shahrami A, et al. Diabetes in Iran: prospective analysis from first nationwide diabetes report of National Program for Prevention and Control of Diabetes (NPPCD-2016). Sci Rep. 2017 Oct 18;7(1):13461. doi: 10.1038/s41598-017-13379-z.
24. Alberti K, Zimmet P. Definition, diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation. Diabet Med. 1998 Jul;15(7):539-53. doi: 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S.
25. Association AD. Summary of Revisions: Standards of Medical Care in Diabetes—2019. Diabetes Care 2019;42(Supplement1):S4–S6.
26. Rabiei Z, Rafieian-Kopaei M. Neuroprotective effect of pretreatment with Lavandula officinalis ethanolic extract on blood-brain barrier permeability in a rat stroke model. Asian Pac J Trop Med. 2014 Sep:7S1:S421-6. doi: 10.1016/S1995-7645(14)60269-8.
27. Sebai H, Selmi S, Rtibi K, Souli A, Gharbi N, Sakly M. Lavender (Lavandula stoechas L.) essential oils attenuate hyperglycemia and protect against oxidative stress in alloxan-induced diabetic rats. Lipids Health Dis. 2013 Dec 28;12:189. doi: 10.1186/1476-511X-12-189.
28. Prusinowska R, Śmigielski KB. Composition, biological properties and therapeutic effects of lavender (Lavandula angustifolia L). A review. Herba Pol. 2014;60(2):56-66. doi:10.2478/hepo-2014-0010.
29. Gray AM, Flatt PR. Insulin-releasing and insulin-like activity of the traditional anti-diabetic plant Coriandrum sativum (coriander). Br J Nutr. 1999 Mar;81(3):203-9. doi: 10.1017/s0007114599000392.
30. Pushparaj PN, Tan BK, Tan CH. The mechanism of hypoglycemic action of the semi-purified fractions of Averrhoa bilimbi in streptozotocin-diabetic rats. Life Sci. 2001 Dec 21;70(5):535-47. doi: 10.1016/s0024-3205(01)01423-0.
31. Patel D, Prasad SK, Kumar R, Hemalatha S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac J Trop Biomed. 2012 Apr;2(4):320-30. doi: 10.1016/S2221-1691(12)60032-X.
32. Rabiei Z, Rafieian-Kopaei M, Mokhtari S, Shahrani M. Effect of dietary ethanolic extract of Lavandula officinalis on serum lipids profile in rats. Iran J Pharm Res. 2014;13(4):1295. PMID: 25587318.
33. Nasri H, Rafieian-kopaei M, Shirzad M, Rafieian M, Sahinfard N, Rafieian S. Effects of Allium sativum on liver enzymes and atherosclerotic risk factors. J Herb Med Pharmacol. 2013.
34. Nasri H, Rafieian-Kopaei M. Oxidative stress and aging prevention. J Res Med Sci. 2015 May; 20(5): 491–502.doi: 10.4103/1735-1995.163977.
35. Asgary S, Sahebkar A, Afshani MR, Keshvari M, Haghjooyjavanmard S, Rafieian‐Kopaei M. Clinical evaluation of blood pressure lowering, endothelial function improving, hypolipidemic and anti‐inflammatory effects of pomegranate juice in hypertensive subjects. Phytother Res. 2014 Feb;28(2):193-9. doi: 10.1002/ptr.4977.
36. Torabzadeh P, Saffari S, Soheili F. Effects of aqueous extract of lavender (Lavandula officinalis) on the liver tissue and blood fat in Balb/C adult female mice. Clin Inves Arterio . 2017 Jan 1;7(2):1456-61.
37. Rafieian-Kopaei M, Baradaran A, Rafieian M. Oxidative stress and the paradoxical effects of antioxidants. J Res Med Sci. 2013 Jul; 18(7): 629. PMID: 24516501
38. Saei H, Azarmi M, Dehghan G, Zehtab Salmasi S, Zeinali S. Hepatoprotective Effect of Ethanolic Extract of Lavandula officinalis L. in Alloxan-Induced Diabetic Rats. Thrita. 2016;5(2):e35306.
39. Al-Azzawie HF, Alhamdani M-SS. Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits. Life Sci. 2006 Feb 16;78(12):1371-7. doi: 10.1016/j.lfs.2005.07.029. Epub 2005 Oct 19.
40. Azarmi M, Saei H, Zehtab Salmasi S, Dehghan G. Investigating the treatable effect of Lavandula officinalis L. Ethanolic extract in alloxan-induced male diabetic rats. Pharmacologyonline. 2016;1:53-63. doi::10.1040/15376516.2019.1567892.
41. Group NDD. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 1979 Dec;28(12):1039-57. doi: 10.2337/diab.28.12.1039.
42. Aju B, Rajalakshmi R, Mini S. Protective role of Moringa oleifera leaf extract on cardiac antioxidant status and lipid peroxidation in streptozotocin induced diabetic rats. Heliyon. 2019 Dec 4;5(12):e02935. doi: 10.1016/j.heliyon.2019.e02935. eCollection 2019 Dec.
43. Esteghamati A, Larijani B, Aghajani MH, Ghaemi F, Kermanchi J, Shahrami A, et al. Diabetes in Iran: prospective analysis from first nationwide diabetes report of National Program for Prevention and Control of Diabetes (NPPCD-2016). Sci Rep. 2017 Oct 18;7(1):13461. doi: 10.1038/s41598-017-13379-z.
44. Alberti K, Zimmet P. Definition, diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation. Diabet Med. 1998 Jul;15(7):539-53. doi: 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S.
45. Association AD. Summary of Revisions: Standards of Medical Care in Diabetes—2019. Diabetes Care 2019;42(Supplement1):S4–S6.
46. Rabiei Z, Rafieian-Kopaei M. Neuroprotective effect of pretreatment with Lavandula officinalis ethanolic extract on blood-brain barrier permeability in a rat stroke model. Asian Pac J Trop Med. 2014 Sep:7S1:S421-6. doi: 10.1016/S1995-7645(14)60269-8.
47. Sebai H, Selmi S, Rtibi K, Souli A, Gharbi N, Sakly M. Lavender (Lavandula stoechas L.) essential oils attenuate hyperglycemia and protect against oxidative stress in alloxan-induced diabetic rats. Lipids Health Dis. 2013 Dec 28;12:189. doi: 10.1186/1476-511X-12-189.
48. Prusinowska R, Śmigielski KB. Composition, biological properties and therapeutic effects of lavender (Lavandula angustifolia L). A review. Herba Pol. 2014;60(2):56-66. doi:10.2478/hepo-2014-0010.
49. Gray AM, Flatt PR. Insulin-releasing and insulin-like activity of the traditional anti-diabetic plant Coriandrum sativum (coriander). Br J Nutr. 1999 Mar;81(3):203-9. doi: 10.1017/s0007114599000392.
50. Pushparaj PN, Tan BK, Tan CH. The mechanism of hypoglycemic action of the semi-purified fractions of Averrhoa bilimbi in streptozotocin-diabetic rats. Life Sci. 2001 Dec 21;70(5):535-47. doi: 10.1016/s0024-3205(01)01423-0.
51. Patel D, Prasad SK, Kumar R, Hemalatha S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac J Trop Biomed. 2012 Apr;2(4):320-30. doi: 10.1016/S2221-1691(12)60032-X.
52. Rabiei Z, Rafieian-Kopaei M, Mokhtari S, Shahrani M. Effect of dietary ethanolic extract of Lavandula officinalis on serum lipids profile in rats. Iran J Pharm Res. 2014;13(4):1295. PMID: 25587318.
53. Nasri H, Rafieian-kopaei M, Shirzad M, Rafieian M, Sahinfard N, Rafieian S. Effects of Allium sativum on liver enzymes and atherosclerotic risk factors. J Herb Med Pharmacol. 2013.
54. Nasri H, Rafieian-Kopaei M. Oxidative stress and aging prevention. J Res Med Sci. 2015 May; 20(5): 491–502.doi: 10.4103/1735-1995.163977.
55. Asgary S, Sahebkar A, Afshani MR, Keshvari M, Haghjooyjavanmard S, Rafieian‐Kopaei M. Clinical evaluation of blood pressure lowering, endothelial function improving, hypolipidemic and anti‐inflammatory effects of pomegranate juice in hypertensive subjects. Phytother Res. 2014 Feb;28(2):193-9. doi: 10.1002/ptr.4977.
56. Torabzadeh P, Saffari S, Soheili F. Effects of aqueous extract of lavender (Lavandula officinalis) on the liver tissue and blood fat in Balb/C adult female mice. Clin Inves Arterio . 2017 Jan 1;7(2):1456-61.
57. Rafieian-Kopaei M, Baradaran A, Rafieian M. Oxidative stress and the paradoxical effects of antioxidants. J Res Med Sci. 2013 Jul; 18(7): 629. PMID: 24516501
58. Saei H, Azarmi M, Dehghan G, Zehtab Salmasi S, Zeinali S. Hepatoprotective Effect of Ethanolic Extract of Lavandula officinalis L. in Alloxan-Induced Diabetic Rats. Thrita. 2016;5(2):e35306.
59. Al-Azzawie HF, Alhamdani M-SS. Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits. Life Sci. 2006 Feb 16;78(12):1371-7. doi: 10.1016/j.lfs.2005.07.029. Epub 2005 Oct 19.
60. Azarmi M, Saei H, Zehtab Salmasi S, Dehghan G. Investigating the treatable effect of Lavandula officinalis L. Ethanolic extract in alloxan-induced male diabetic rats. Pharmacologyonline. 2016;1:53-63. doi::10.1040/15376516.2019.1567892.
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Mahmoodnia L, Forouzandeh Shahrakei Z, Hojatyar S, Setorki M. Effects of Lavandula Angustifolia Hydroalcoholic Extract on the Blood and Urine Biochemical Factors of Diabetic Patients: A Placebo-Controlled Clinical Trial. Journal of Basic Research in Medical Sciences 2024; 11 (2) :53-61
URL: http://jbrms.medilam.ac.ir/article-1-781-en.html
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Volume 11, Issue 2 (4-2024) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
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