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:: Volume 11, Issue 2 (4-2024) ::
2024, 11(2): 1-12 Back to browse issues page
Risk factors affecting abortion among pregnant women– A case-control study
Shima Hashemi , Ashraf Direkvand Moghadam , Kourosh Sayehmiri , Mirhadi Mousavi , Hamzeh Ahmadi , Monireh Azizi , Khairollah Asadollahi
Department of Epidemiology, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran , Masoud_1241@yahoo.co.uk
Abstract:   (440 Views)
Introduction: Abortion, a common pregnancy complication, is influenced by multifaceted reproductive, economic, social, and cultural factors. This study investigates abortion determinants among pregnant women in Khorramabad, Iran, from September 2020 to March 2021.
Material & Methods: This case-control study involved 416 pregnant women (208 cases, 208 controls) selected from Khorramabad health centers through census and random sampling during the COVID-19 pandemic. Data on demographics and pregnancy history were collected using a checklist and analyzed with STATA16.
Results: Among the 416 pregnant women, the mean age was 31.00 ± 5.53 years in the control group and 32.27 ± 6.85 years in the case group. Furthermore, 74 (35.58%) mothers in the case group had a diploma, 192 (92.31%) were housewives, and 106 (50.96%) had A+ blood group. The majority of mothers (46.63% in case, 39.42% in control) had an overweight range of pre-pregnancy BMI (25-29.9) (kg/m2). The mean height was 162.97 ± 5.30 in the control group and 160.86 ± 5.39 in the case group. Multiple regression logistic analysis confirmed significant associations between abortion and mother's age (OR=4.67, 95%CI=1.11-19.62), previous cesarean delivery (OR=4.33, 95%CI=1.94-9.66), not taking folic acid pills during pregnancy (OR=14.92, 95%CI=6.25-35.61), low income (OR=7.00, 95%CI=2.02-24.35), not smoking (OR=0.28, 95%CI=0.08-0.94), and absence of pre-diabetes (OR=0.13, 95%CI=0.03-0.47) (p < 0.05). No significant relationships were found between abortion and other studied risk factors.
Conclusion:  Older mothers with lower income levels are more likely to experience abortion. Additionally, factors such as pre-existing pre-diabetes, previous cesarean deliveries, smoking, lack of folic acid supplementation, and maternal infections are identified as risk factors for abortion. Providing education, healthcare, and continuous support from healthcare workers can promote safe pregnancies, reduce the risk of abortion, and enhance maternal and child health outcomes.

Keywords: Abortion, Pregnancy, Mothers, Child
Full-Text [PDF 818 kb]   (152 Downloads)    
Type of Study: Research | Subject: Midwifery
Received: 2023/12/14 | Accepted: 2024/04/2 | Published: 2024/04/22
1. Carp, H. J. A. Progestogens and pregnancy loss. Climacteric. 2018; 22:1-5. doi.org/10.1080/13697137.2018.1436166
2. Smorgick N, Mittler A, Ben-Ami I, Maymon R, Vaknin Z, Pansky M. Retained products of conception: What is the risk for recurrence on subsequent pregnancies? Eur J Obstet Gynecol Reprod Biol. 2018; 5(224):1-5. doi.org/10.1016/j.ejogrb.2018.03.006
3. Kaser D. The status of genetic screening in recurrent pregnancy loss. Obstet Gynecol Clin North Am. 2018; 45(1):143-154. DOI: 10.1016/j.ogc.2017.10.007
4. Ammon Avalos L, Galindo C, Li DK. A systematic review to calculate background miscarriage rates using life table analysis. Birth Defects Res Part A Clin Mol Teratol. 2012; 94(6):417-23. DOI: 10.1002/bdra.23014
5. Akhtari E. Pregnancy termination from ancient Persia till present time. Iran J Obstet Gynecol Infertil. 2017; 19(40):1-5. Doi: 10.22038/ijogi.2017.8442
6. Bearak J, Popinchalk A, Ganatra B, Moller A-B, Tunçalp Ö, Beavin C et al. Unintended pregnancy and abortion by income, region, and the legal status of abortion: estimates from a comprehensive model for 1990–2019. Lancet Glob Health. 2020 Sep; 8(9):e1152-e1161. doi: 10.1016/S2214-109X(20)30315-6.
7. Ganatra B, Gerdts C, Rossier C, Ronald Johnson Jr B, Tuncalp O, Assifi A, et al. Global, regional and subregional classification of abortions by safety 2010-14: Estimates from a Bayesian hierarchical model. Lancet. 2017; 390(10110): 2372-81. DOI: 10.1016/S0140-6736(17)31794-4
8. Guttmacher Institute. Unintended pregnancy and abortion worldwide [Internet]. 2020. [updated 2020 July]. Available from: https://www.guttmacher.org/fact-sheet/induced-abortion-worldwide.
9. Rastegari A, Baneshi MR, Haji-Maghsoudi S, Nakhaee N, Eslami M, Malekafzali H, et al. Estimating the annual incidence of abortions in Iran applying a network scale-up approach. Iran Red Crescent Med J. 2014; 16(10): e15765. [In Persian]
10. Chan RL, Olshan AF, Savitz DA, Herring AH, Daniels JL, Peterson HB, et al. Severity and duration of nausea and vomiting symptoms in pregnancy and spontaneous abortion. Human reproduction. 2010; 25(11):2907-12. doi: 10.1093/humrep/deq260
11. Moradinazar Mehdi, Najafi Farid, Moradi Nazar Zeinab, Hamzeh Behrooz, Pasdar Yahya, Shakiba Ebrahim. Lifetime Prevalence of Abortion and Risk Factors in Women: Evidence from a Cohort Study. Journal of Pregnancy. 2020: 1-8. [DOI:10.1155/2020/4871494]
12. Nazarpour S, Tehrani FR, Simbar M, Azizi F. Thyroid dysfunction and pregnancy outcomes. Iranian journal of reproductive medicine. 2015; 13(7):387-96. PMID: 26494985 PMCID: PMC4609317
13. Maghsoudi R, Mirhosseini M. Spontaneous abortion and anti-thyroid antibodies in mother’s serum. Life Science Journal. 2014; 11:41-4. https://www.scopus.com/inward/record.uri?eid=2-s2....
14. Pershad J, Mugerwa KY, Filippi V, et al. Prevalence and determinants of self-reported anxiety and stress among women with abortion-related complications admitted to health facilities in Eastern and Southern Africa: A cross-sectional survey. Int J Gynecol Obstet. 2022; 156 (1): 53–62. doi:10.1002/ijgo.14042
15. Frederico M, Michielsen K, Arnaldo C, Decat P. Factors influencing abortion decision-making processes among young women. Int J Environ Res Public Health. 2018;15(2):329-42. doi: 10.3390/ijerph15020329
16. Alexander P, Frick MD MRCOG. Advanced maternal age and adverse pregnancy outcomes. Journal of Best Practice & Research Clinical Obstetrics & Gynaecology. 2021: 92-100. [DOI:10.1016/j.bpobgyn.2020.07.005]
17. Rosaly Correa-de-Araujo, Sung Sug (Sarah) Yoon. Clinical Outcomes in High-Risk Pregnancies Due to Advanced Maternal Age. Journal of Women's Health. 2021: 30(2). [DOI:10.1089/jwh.2020.8860]
18. The practice committee of the American society for reproductive medicine. Evaluation and treatment of recurrent pregnancy loss: a committee opinion. Fertility and Sterility. 2012: 98 (5): 1103-11.
19. Erfani A. Tehran survey of fertility. A study on the reproductive behavior of married women in Tehran. Tehran: The population studies and research center in Asia and pacific (PSRC). 2010. https://www.scirp.org/reference/referencespapers?referenceid=1170785
20. Martin JA, Hamilton BE, Osterman MJK, Hyattsville, MD. Births: Final data for 2016. National vital statistics reports. sNational Center for Health Statis-tics, 2018: 67(1).
21. Pourjafari H, Hashemzadeh Chaleshtori M, Arab M. Frequencies of antigens and their alleles from ABO & RH blood types in a group of women with two or more abortions. Avicenna Journal of Clinical Medicine 2004; 10(4):43-46. https://www.sid.ir/paper/538877/en
22. Shahverdi E, Moghaddam M, Talebian A, Abolghasemi H. Distribution of blood groups in the Iranian general population. J Blood Group Serol Mol Genet. 2016; 32(4):135. PMID: 28257227
23. Higgins JR, Walshe JJ, Darling MR, Norris L, Bonnar J. Hemostasis in the uteroplacental and peripheral circulations in normotensive and pre-eclamptic pregnancies. Am J Obstet Gynecol. 1998; 179(2): 520-6. DOI: 10.1016/s0002-9378(98)70389-8
24. Hassanzadeh-Nazarabadi M, Shekouhi S, Seif N. The Incidence of Spontaneous Abortion in Mothers with Blood Group O Compared with other Blood Types. Int J Mol Cell Med. 2012; 1(2):99-104. PMID: 24551765 PMCID: PMC3920496
25. Karbasian Zahra. The relationship between pregnant mothers addiction with abortion. New advances in psychology, education, and education. 2018; 1(2): 59-67.
26. Skogsdal Y, Karlsson J, Tydén T, Patil S, Backman H. The association of smoking, use of snuff, and preconception alcohol consumption with spontaneous abortion: A population-based cohort study. Acta Obstet Gynecol Scand. 2023;102:15-24. doi: 10.1111/aogs.14470
27. Triggianese P, Perricone C, Perricone R, De Carolis C. Prolactin and Natural Killer Cells: Evaluating the Neuroendocrineimmune Axis in Women with Primary Infertility and Recurrent Spontaneous Abortion. Am J Reprod Immunol. 2014. DOI:10.1111/aji.12335
28. Khazaei S, Soltani O. Caffeine intake and spontaneous aboration. SCIENTIFIC JOURNAL ofIlam Medical University. 2003: 10(36, 37): 39-45. DOI: 10.1056/NEJM200012213432503
29. Kitts DD. Caffeine metabolism and its deposition in the pregnant rat andfetus. cand instfood sir technol J 1986 ; 19: XL.
30. Pustejovsky JE, Rodgers MA. Testing for funnel plot asymmetry of standardized mean differences. Res Synth Methods. 2019; 10: 57–71. doi.org/10.1002/jrsm.1332
31. Afolabi BB, Moses OE, Oduyebo OO. Bacterial vaginosis and pregnancy outcome in Lagos, Nigeria. Open Forum Infect Dis. 2016; 3:ofw030. doi:10.1093/ofid/ofw030.
32. Erfani A. Induced abortion in Tehran, Iran: Estimated rates and correlates. Int Perspect Sex Report Health. 2011; 37(3): 134-42. DOI: 10.1363/3713411
33. Ford J.H, MacCormac L. Pregnancy and lifestyle study: the long-term use of the contraceptive pill and the risk of agerelated miscarriage. Human Reproduction. 1995: 10(6): 1397–1402. DOI: 10.1093/humrep/10.6.1397
34. L. Michie, S.T. Cameron. Emergency contraception and impact on abortion rates. . Journal of Best Practice & Research Clinical Obstetrics & Gynaecology. 2020: 111-119. [DOI:10.1016/j.bpobgyn.2019.06.008]
35. Kovacs P, Barg P.E, Witt B.R. “Hypothalamic-pituitary suppression with oral contraceptive pills does not improve outcome in poor responder patients undergoing in vitro fertilization-embryo transfer cycles,” Journal of Assisted Reproduction and Genetics. 2001: 18(7): 391–394. DOI: 10.1023/a:1016626607387
36. Hansen M-LH, Mølgaard-Nielsen D, Knudsen LB, Keiding N. Rates of induced abortion in Denmark according to age, previous births and previous abortions. Demographic Research. 2009; 21: 647-80. Doi: 10.4054/DemRes.2009.21.22
37. Mahmoudiani S, Ahmadi AY, Javadi A. The Prevalence and Influential Factors of Abortion in the Women in the Rural Areas of Fars Province, Iran (2015). Iran Journal of Nursing. 2018; 31(115):51-61. Doi: 10.29252/ijn.31.115.51
38. Abbasi Shavazi Mj, Khani S. Economic Insecurity, Marriage and Fertility Ideals: A study among Mothers and Children Generation in Sanandaj District, Journal of Population Studies. 2016: 1(2): 63-99. Doi: 20.1001.1.1735000.1393.
39. Alemayehu M, Yebyo H, Medhanyie AA, Bayray A, Fantahun M, Goba GK. Determinants of repeated abortion among women of reproductive age attending health facilities in Northern Ethiopia: a case–control study. BMC Public Health. 2017; 17(1): 188-96. DOI: 10.1186/s12889-017-4106-1
40. Chinichian M, Halakooii-Naiini K, Rafaii-Shirpak K.. Voluntary Abortion in Iran: a qualitative study, Journal of Payesh. 2007: 6(3): 219-32. URL: http://payeshjournal.ir/article-1-701-en.html
41. Neela J, Raman L. The relationship between maternal nutritional status and spontaneous abortion. Natl Med J India. 1997; 10(1):15-6. PMID: 9069700.
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Hashemi S, Direkvand Moghadam A, Sayehmiri K, Mousavi M, Ahmadi H, Azizi M et al . Risk factors affecting abortion among pregnant women– A case-control study. Journal of Basic Research in Medical Sciences 2024; 11 (2) :1-12
URL: http://jbrms.medilam.ac.ir/article-1-801-en.html

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Volume 11, Issue 2 (4-2024) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
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