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:: Volume 11, Issue 4 (9-2024) ::
2024, 11(4): 20-27 Back to browse issues page
Predictive marker of disease activity in breast cancer patienta with and without metastasis
Hassan Nourmohammadi , Syedeh negin Mirbeigi , Arash Nademi , Elham Shafiei
Clinical Research Development Unit, Ayatollah Taleghani Hospital, Ilam University of Medical Sciences, Ilam, Iran , shafiei-e@medilam.ac.ir
Abstract:   (182 Views)
Background:  Levels of the human epidermal growth factor receptor 2 (HER2) gene are low in normal breast tissue, but half of patients with breast cancer have higher levels of this receptor. The different expression levels of the HER2 gene in normal and malignant cells make this gene an excellent biomarker for therapeutic purposes. In this study, we evaluated the degree of HER2 overexpression in patients, its relationship with age and the occurrence of metastases.
Methods: In this retrospective, registry-based and two-center cohort study, information of 1500 patients with breast cancer recruited at the Shahid Mostafa Khomeini hospital in Ilam province was collected during the years 2020 to 2023.
Results: The possible of metastasis in cancer patients who had the HER2 gene expression was 3 times higher (adjusted OR: 2.82; 95% CI: 1.79 – 3.29; P=0.001).  Also, Nodes involved (adjusted OR: 2.01; 95% CI: 0.87 – 3.79; P=0.03) was significantly associated with increased metastasis.
Conclusion: This study showed that the significant prognostic factor of the number of involved lymph nodes and HER2 gene expression is known as a factor that increases the risk of metastasis. Therefore, creating a background for breast cancer screenings can be an important factor for the treatment of the disease and the prevention of metastasis in breast cancer patients.
 
Keywords: Breast Neoplasms, ERBB2 protein, human, Neoplasm Metastasis
Full-Text [PDF 1346 kb]   (60 Downloads)    
Type of Study: Research | Subject: Microbiology
Received: 2024/04/13 | Accepted: 2024/07/22 | Published: 2024/09/18
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Nourmohammadi H, mirbeigi S N, Nademi A, Shafiei E. Predictive marker of disease activity in breast cancer patienta with and without metastasis. Journal of Basic Research in Medical Sciences 2024; 11 (4) :20-27
URL: http://jbrms.medilam.ac.ir/article-1-844-en.html


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Volume 11, Issue 4 (9-2024) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
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