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Volume 13, Issue 1 (1-2026)
jbrms 2026, 13(1): 1-11 |
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Kiani Motlagh Jonaghani M, Zahedi A, Mojiri-Forushani H, Kanani K, Mobarak S, Radmanesh E. Comparative Investigation of Renal, Hepatic and Coagulation Diagnostic Factors in Patients with Cirrhosis and Hepatitis. jbrms 2026; 13 (1) :1-11
URL: http://jbrms.medilam.ac.ir/article-1-983-en.html
URL: http://jbrms.medilam.ac.ir/article-1-983-en.html
Mehdi Kiani Motlagh Jonaghani 
, Atefeh Zahedi , Hoda Mojiri-Forushani , Khadijeh Kanani , Sara Mobarak , Esmat Radmanesh
, Atefeh Zahedi , Hoda Mojiri-Forushani , Khadijeh Kanani , Sara Mobarak , Esmat Radmanesh
Department of Physiology, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran , esmatradmanesh33@gmail.com
Abstract: (70 Views)
Introduction: Evaluating the level of kidney, liver, coagulation, and blood diagnostic markers in cirrhosis and hepatitis patients can help in early diagnosis, timely treatment, and prevention of complications of these diseases.
Materials & Methods: This study is an analytical cross-sectional study. After obtaining the necessary permits by referring to the medical records department of Abadan and Khorramshahr educational hospitals, the information of patients (148 patients) with liver cirrhosis and hepatitis admitted from March 21, 2017, to March 19, 2020, available in the HIS, was obtained. Patient data was analysed using IBM SPSS software (version 16). Data compared means among study groups using t-tests and two-way ANOVA. A p-value < 0.05 was considered statistically significant.
Results: In both diseases, the mean levels of Hb and Hct were lower than the normal range, while the mean of FBS, total and direct bilirubin, AST, ALT, ALP, PT, and INR were higher than the normal range. Comparing the markers between liver cirrhosis and hepatitis, the mean levels of BS, FBS, BUN, and creatinine were significantly higher in cirrhosis. The means of LDL, Na, direct and total bilirubin, AST, and ALT were significantly higher in hepatitis.
Conclusion: According to the research, cirrhosis tends to occur at an older age than hepatitis. Both diseases are more prevalent among men. In cirrhosis, mean blood sugar and renal markers (creatinine and BUN) were significantly higher than in hepatitis. Liver diagnostic markers (direct and total bilirubin, AST, and ALT) and LDL were significantly higher in hepatitis than in cirrhosis.
Materials & Methods: This study is an analytical cross-sectional study. After obtaining the necessary permits by referring to the medical records department of Abadan and Khorramshahr educational hospitals, the information of patients (148 patients) with liver cirrhosis and hepatitis admitted from March 21, 2017, to March 19, 2020, available in the HIS, was obtained. Patient data was analysed using IBM SPSS software (version 16). Data compared means among study groups using t-tests and two-way ANOVA. A p-value < 0.05 was considered statistically significant.
Results: In both diseases, the mean levels of Hb and Hct were lower than the normal range, while the mean of FBS, total and direct bilirubin, AST, ALT, ALP, PT, and INR were higher than the normal range. Comparing the markers between liver cirrhosis and hepatitis, the mean levels of BS, FBS, BUN, and creatinine were significantly higher in cirrhosis. The means of LDL, Na, direct and total bilirubin, AST, and ALT were significantly higher in hepatitis.
Conclusion: According to the research, cirrhosis tends to occur at an older age than hepatitis. Both diseases are more prevalent among men. In cirrhosis, mean blood sugar and renal markers (creatinine and BUN) were significantly higher than in hepatitis. Liver diagnostic markers (direct and total bilirubin, AST, and ALT) and LDL were significantly higher in hepatitis than in cirrhosis.
Type of Study: Research |
Subject:
Gastroenterology
Received: 2025/06/18 | Accepted: 2025/09/2 | Published: 2026/01/4
Received: 2025/06/18 | Accepted: 2025/09/2 | Published: 2026/01/4
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