:: Volume 4, Issue 4 (9-2017) ::
2017, 4(4): 8-12 Back to browse issues page
Evaluation of PPP2R5C gene expression in Iranian patients with B-Acute lymphoblastic leukemia and its association with clinical and laboratory findings
Esmaeil Rostami, Hossein Ayatollahi, Hassan Boustani, Abbas Ghotaslou, Mohammad Hadi Sadeghian, Mohammad Reza Keramati, Elahe Zeinali, Abolfazl Rad
Department of Hematology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran , a.ghotaslou@gmail.com
Abstract:   (4068 Views)

Introduction: PPP2R5C is one of the regulatory B subunits of protein phosphatase 2A (PP2A), which is a tumor suppressor. PPP2R5C plays a critical role in cell proliferation, differentiation, and transformation. Considering these vital functions, we investigate the gene expression in Iranian patients with B-Acute Lymphoblastic Leukemia (B-ALL) and its association with clinical and laboratory finding.

Materials and methods: In this case-control study, peripheral blood samples were collected from 60 B-ALL patients and 30 healthy controls. PPP2R5C expression levels were determined by Real-time PCR. After calculation of CT for target and control genes, we calculated ΔCT. Finally we compared the PPP2R5C expression levels in patients with control group.

Results: Significantly higher expression of PPP2R5C was found in the B-ALL patients (2.15±2. 50) compared with control group. There was no correlation between PPP2R5C expression and clinical and laboratory findings and FAB (French-American-British) subtype of patients.

Conclusion: we demonstrated PPP2R5C overexpression in B-ALL patients. Although there was no significant correlation between PPP2R5C expression, clinical and laboratory finding and also with FAB subtypes of patients.

Keywords: B-Acute Lymphoblastic Leukemia, PPP2R5C, PP2A, Gene expression
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Type of Study: Research | Subject: Hematology
Received: 2017/02/22 | Accepted: 2017/04/21 | Published: 2017/06/15

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