:: Volume 7, Issue 2 (3-2020) ::
2020, 7(2): 1-6 Back to browse issues page
Distinctive deregulation of miR-27a and miR-27b in relapsing remitting multiple sclerosis
Jalil Shafiei , Farideh Heidari , Elham Khashen , Rana Ghandehari‐Alavijeh , Zahra Darmishonnejad
Department of Genetic, Science and Research Branch, Islamic Azad University, Tehran, Iran , Jalilshafiei20@gmail.com
Abstract:   (2225 Views)
Introduction: Previous studies have proposed that microRNAs (miRNAs) expression might be responsible for immunological features associated with multiple sclerosis (MS) pathogenesis. We aimed to elucidate the alternation in miR-27a and miR-27b expression in relapsing-remitting multiple sclerosis (RRMS) patients compared to the healthy subjects.
Materials and methods: In this study, the expression levels of miR-27a and miR-27b were evaluated in peripheral blood samples of 60 RRMS patients (30 recurrence patients and 30 patients two months after relapse) and 30 healthy subjects by quantitative real-time PCR.
Results: The findings indicated that the expression of miR-27a was significantly decreased in recurring patients (P<0.0001) and two months after relapse patients (P<0.003) in comparison with healthy subjects. Moreover, miR-27b showed down regulation in recurring patients (P<0.001) and two months after relapse patients (P<0.002).
Conclusion: The results demonstrated an association between expression of miRNAs studied and RRMS disease during recurrence and two months after relapse. However, further research is warranted to confirm observed associations.
Keywords: microRNA, miR-27a, miR-27b, Multiple sclerosis
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Type of Study: Research | Subject: Genetics
Received: 2020/02/16 | Accepted: 2020/04/17 | Published: 2020/06/6

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Volume 7, Issue 2 (3-2020) Back to browse issues page