:: Volume 10, Issue 4 (12-2023) ::
2023, 10(4): 67-80 Back to browse issues page
The Impact of Capecitabine and Combined Training on BRCA1 Gene Expression in Breast Cancer Induction
Masoud Shokuhi Niya , Abbas Salehikia , Maryam Banparvari , Hamed Fanaei
Department of Sport Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, Iran , salehikia@ped.usb.ac.ir
Abstract:   (725 Views)
Introduction: This study explores the combined effects of concurrent training and capecitabine consumption on breast cancer prevention and therapy, focusing on the modulation of BRCA1 gene expression.
Material & Methods: In the main study, 12 mice were divided into groups, including Exercise-Tumor-Exercise (ETE), Exercise-Tumor-Exercise+Drug (ETE + D), and various others. Resistance and endurance training were conducted five days a week for 12 weeks before and eight weeks after tumor induction, accompanied by capecitabine administration. BRCA1 gene expression was assessed post-intervention using SPSS 20.
Results: MC4-L2 injection induced tumors. Both pre and post-cancer induction, exercise significantly increased BRCA1 gene expression (p = 0.001, p = 0.001). Exercise combined with post-cancer capecitabine led to increased BRCA1 expression (p = 0.001). Capecitabine alone post-cancer also elevated BRCA1 expression (p = 0.001). Exercise, exercise with capecitabine, and capecitabine alone post-cancer showed significantly higher BRCA1 expression than exercise pre-cancer (p = 0.001). Exercise-tumor-exercise and Exercise-Tumor-Exercise+Drug groups exhibited increased BRCA1 expression compared to exercise-tumor-drug (p = 0.001).
Conclusion: The ETE+D protocol, involving exercise and capecitabine post-cancer, increased BRCA1 expression, suggesting potential roles in tumor prevention and therapy.
Keywords: Breast cancer, Tumor size, Exercise Therapy, BRCA1, Capecitabine
Full-Text [PDF 1352 kb]   (292 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2023/05/20 | Accepted: 2023/12/28 | Published: 2023/12/28
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