:: Volume 11, Issue 3 (6-2024) ::
2024, 11(3): 56-65 Back to browse issues page
The Impact of Specific Physical Training on FGF-2 and VEGF-A Expression in Patients Post-Coronary Artery Bypass Surgery
Maryam Monjezi , Alireza Barari , Ahmad Abdi
& 1 Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran , alireza54.barari@gmail.com
Abstract:   (30 Views)
Introduction:  Coronary artery bypass surgery (CABG) is a common procedure for patients with coronary artery disease. This study aimed to investigate the effect of selected physical exercises on the expression of FGF-2 and VEGF-A in patients post-CABG.
Material & Methods: In this semi-experimental study, 20 male patients from Afshar Hospital (Yazd City) who had undergone CABG were selected and randomly divided into two groups: a combined training group and a control group. The combined training group performed an 8-week program consisting of endurance training (15-20 minutes at 50-60% of HRmax) and resistance training (10-20 minutes, including three upper limb and two lower limb movements, each with three sets of 10 repetitions at 30-60% of 1RM), conducted three times per week. Gene expression of Fibroblast Growth Factor 2 (FGF-2) and Vascular Endothelial Growth Factor A (VEGF-A) was measured using Real-Time PCR. Data were analyzed using paired t-tests and one-way ANOVA with a significance level set at P<0.05.
Results: An increase in the expression of VEGF and FGF-2 genes was observed in the combined training group post-test compared to pre-test (p=0.019). Additionally, there was a significant difference in VEGF gene expression between the control and training groups (p=0.016). Significant differences were also found in FGF-2 expression between the combined exercise group and both the healthy control and patient control groups (p=0.001 for both).
 
Conclusion: The results suggest that combined exercises may enhance physiological adaptations and improve the functional capacity of the heart and vessels in CABG patients by increasing growth factor expression.

 
Keywords: The results suggest that combined exercises may enhance physiological adaptations and improve the functional capacity of the heart and vessels in CABG patients by increasing growth factor expression.
Full-Text [PDF 1376 kb]   (7 Downloads)    
Type of Study: Research | Subject: Public health
Received: 2023/05/30 | Accepted: 2023/06/8 | Published: 2024/06/21
References
1. Jannati M, Attar A. Analgesia and sedation postcoronary artery bypass graft surgery: a review of the literature. Ther Clin Risk Manag. 2019;15:773.doi: 10.2147/TCRM.S195267.
2. Giorgini JC, Rubio M, Baldi J, David M, Higa C, Borracci RA, et al. Short-Term Outcomes of Isolated and Combined Coronary Artery Bypass Graft Surgery in Women. Rev Argent Cardiol. 2020;88(5):448-53.doi: 10.1136/openhrt-2015-000386.
3. Balakrishnan, Sheeja, and Senthil Kumar B. “Correlation of serum vascular endothelial growth factor and cardiovascular risk factors on collateral formation in patients with acute coronary artery syndrome. Clin Anat. 2022 Jul;35(5):673-678. doi: 10.1002/ca.23890.
4. Gilani N, Kazemnejad A, Zayeri F, Hadaegh F, Azizi F, Khalili D. Anthropometric indices as predictors of coronary heart disease risk: Joint modeling of longitudinal measurements and time to event. Iran J Public Health. 2017;46(11):1546.
5. Scioli, M.G.; Storti, G.; D’Amico, F.; Rodríguez Guzmán, R.; Centofanti, F.; Doldo, et al. Oxidative Stress and New Pathogenetic Mechanisms in Endothelial Dysfunction: Potential Diagnostic Biomarkers and Therapeutic Targets. J. Clin. Med. 2020, 9, 1995.doi: 10.3390/jcm9061995.
6. Zhou Y, Zhu X, Cui H, Shi J, Yuan G, Shi S, Hu Y. The Role of the VEGF Family in Coronary Heart Disease. Front Cardiovasc Med. 2021; 8:738325. doi: 10.3389/fcvm.2021.738325.
7. Podemska-Jedrzejczak Z, Malinska A, SujkaKordowska P, Nowicki M, Puslecki M, Jemielity M, et al. Vascular restenosis in coronary artery bypass grafting might be associated with VEGF-C/VEGFR-3 signaling pathway. Heart Vessels. 2018;33(9):1106- 20. doi: 10.1007/s00380-018-1158-9.
8. Zangi L, Lui KO, Von Gise A, Ma Q, Ebina W, Ptaszek LM, et al. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol. 2013;31(10):898-907.doi: 10.1038/nbt.2682.
9. Hamidi A, Rashidlamir A, Khajei R, Zarei M, Zendedel A. The Effect of Aerobic-resistance Training on Plasma Levels of bFGF in Coronary Artery Disease After CABG. J Arak Uni Med Sci 2020; 23 (3) :314-325
10. Cavalcante SL, Lopes S, Bohn L, Cavero-Redondo I, Álvarez-Bueno C, Viamonte S, Santos M, Oliveira J, Ribeiro F. Effects of exercise on endothelial progenitor cells in patients with cardiovascular disease: A systematic review and meta-analysis of randomized controlled trials. Rev Port Cardiol (Engl Ed). 2019 Nov;38(11):817-827. English, Portuguese. doi: 10.1016/j.repc.2019.02.016.
11. Ghorbanzadeh V, Mohammadi M, Dariushnejad H, Chodari L, Mohaddes G. Effects of crocin and voluntary exercise, alone or combined, on heart VEGF-A and HOMA-IR of HFD/STZ induced type 2 diabetic rats. J Endocrinol Invest. 2016 Oct;39(10):1179-86. doi: 10.1007/s40618-016-0456-2.
12. Danzig V, Míková B, Kuchynka P, Benáková H, Zima T, Kittnar O, et al. Levels of circulating biomarkers at rest and after exercise in coronary artery disease patients. Physiol Res. 2010;59(3):385-392. doi: 10.33549/physiolres.931764.
13. Hoier B, Nordsborg N, Andersen S, Jensen L, Nybo L, Bangsbo J, et al. Pro- and anti-angiogenic factors in human skeletal muscle in response to acute exercise and training. J Physiol. 2012 1;590(3):595-606. doi: 10.1113/jphysiol.2011.216135
14. Paluch AE, Boyer WR, Franklin BA, Laddu D, Lobelo F, Lee DC, et al A; on behalf the American Heart Association Council on Lifestyle and Cardiometabolic Health; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Epidemiology and Prevention; and Council on Peripheral Vascular Disease. Resistance Exercise Training in Individuals With and Without Cardiovascular Disease: 2023 Update: A Scientific Statement From the American Heart Association. Circulation. 2024 Jan 16;149(3):e217-e231. doi: 10.1161/CIR.0000000000001189.
15. Vuorio T, Jauhiainen S, Ylä-Herttuala S. Pro- and anti-angiogenic therapy and atherosclerosis with special emphasis on vascular endothelial growth factors. Expert Opin Biol Ther. 2012;12(1):79-92. doi: 10.1517/14712598.2012.641011.
16. Burton PB, Owen VJ, Hafizi S, Barton PJ, Carr-White G, Koh T, De Souza A, Yacoub MH, Pepper JR. Vascular endothelial growth factor release following coronary artery bypass surgery: extracorporeal circulation versus 'beating heart' surgery. Eur Heart J. 2000;21(20):1708-13. doi: 10.1053/euhj.2000.2177.
17. Sun Z, Shen Y, Lu L, Zhang RY, Pu LJ, Zhang Q, et al. Increased serum level of soluble vascular endothelial growth factor receptor-1 is associated with poor coronary collateralization in patients with stable coronary artery disease. Circ J. 2014;78(5):1191-6. doi: 10.1253/circj.cj-13-1143.
18. Nelken NA, Coughlin SR, Gordon D, Wilcox JN. Monocyte chemoattractant protein-1 in human atheromatous plaques. J Clin Invest. 1991 Oct;88(4):1121-7. doi: 10.1172/JCI115411.
19. Braile M, Marcella S, Cristinziano L, Galdiero MR, Modestino L, Ferrara AL, et al. VEGF-A in Cardiomyocytes and Heart Diseases. Int J Mol Sci. 2020 Jul 26;21(15):5294. doi: 10.3390/ijms21155294.
20. Abdi H, Shamsaei N, Jafari M. [The role of aerobic training in protein expression of stromal cell-derived factor-alpha and apoptotic death of cardiomyocyte after experimental myocardial infarction]. Journal of Practical Studies of Biosciences in Sport. 2019; 7(14): 103-15. DOI: 10.22077/JPSBS.2017.489.1190
21. 1. Ellison GM, Waring CD, Vicinanza C, Torella D. Physiological cardiac remodelling in response to endurance exercise training: cellular and molecular mechanisms. Heart. 2012; 98(1): 5- 10. DOI: 10.1136/heartjnl-2011-300639
22. Yang X, Chrisman H, Weijer CJ. PDGF signalling controls the migration of mesoderm cells during chick gastrulation by regulating N-cadherin expression. Development. 2008; 135(21): 3521-30. DOI: 10.1242/dev.023416
23. Samsa LA, Yang B, Liu J. Embryonic cardiac chamber maturation: Trabeculation, conduction, and cardiomyocyte proliferation. Am J Med Genet C Semin Med Genet. 2013 Aug; 163C(3): 157-68. DOI:10.1002/ajmg.c.31366
24. Gaeini AA, Sattarifard S, CafiZadeh S, Nejatian M. [The comparison of eight weeks of combined and aerobic training on functional capacity, body composition and strength in postcoronary artery bypass graft cardiac patients]. Cardiovasc Nurs. 2013; 2(1): 34-41. [Article in Persian].

XML     Print

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 11, Issue 3 (6-2024) Back to browse issues page