logo
Volume 13, Issue 2 (4-2026)                   jbrms 2026, 13(2): 48-55 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Nourolahi S, Shafiei E, Pournajaf Z. Evaluation of Prevalence and Severity and Risk Factors of Retinopathy Prematurity in Premature Infants in Ilam. jbrms 2026; 13 (2) :48-55
URL: http://jbrms.medilam.ac.ir/article-1-1026-en.html
Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran , eshafiei1524@gmail.com
Abstract:   (269 Views)
Introduction: Retinopathy of prematurity (ROP) is a retinal proliferative vascular disorder of premature infants. In spite of improvement in the management of neonatal disorders, ROP is one of the leading causes of blindness in premature infants in the world. Present screening of ROP first is based on risk factors of birth weight and gestational age. Nevertheless, some authors believe that other risk factors, including maternal and perinatal factors and nutrition and genetics, are effective too. Nevertheless, we decided to study risk factors of ROP in neonates.
Materials & Methods: This cross-sectional study on the population of neonates born in Ilam hospitals during 2012-2018. In this study we evaluated ROP in premature infants that were hospitalized in Ilam hospitals.
Results:  Altogether, 627 infants were evaluated, among them 332 boys and 295 girls. For the mean of birth weight between them, there was a significant difference (P-value=0.001). In addition, gestational age according to sex had a difference; in girls it was less than boys, and it was statistically significantly different (P-value=0.001). ROP was found to be significantly more prevalent in girls compared to boys. Prevalence of ROP among girls and boys was 27.8% and 15.7%, respectively. The prevalence of retinopathy in two sexes was 18.7%.
Conclusion:  Among these factors, birth weight, gestational age, blood transfusion history, PDA, and asphyxia had statistically significant differences with the occurrence of ROP. The best way to avoid the progression of ROP is screening and examination and timely treatment of this disorder.
 
Full-Text [PDF 661 kb]   (69 Downloads)    
Type of Study: Research | Subject: Pediatrics
Received: 2025/09/6 | Accepted: 2025/12/14 | Published: 2026/04/6

References
1. Huang D, Liu Z, Deng Y. Retinopathy of Prematurity (ROP): An Overview of Biomarkers in Various Samples for Prediction, Diagnosis, and Prognosis. Clinical Ophthalmology. 2025:1515-30. https://doi.org/ 10.2147/OPTH.S519292. [DOI:10.2147/OPTH.S519292.]
2. Silva LS, Mendonça AC, Albano PD. Risk factors for retinopathy of prematurity in preterm newborns from a Brazilian maternity hospital: a cross-sectional study (2014-2022). Caderno Pedagógico. 2025;22(7):e16446-e.
3. Barresi C, Abdelmassih Y, Caputo G. Pediatric and developmental conditions. Ultra Widefield Imaging of the Retina: Elsevier; 2025. p. 135-80.
4. Elamurugan V, Narendran S, Varshney T, Babu KN, Rajan RP, Shankaralingappa P, et al. Topical application of Ringer’s lactate for Stage 1 Retinopathy of Prematurity: A potential treatment hypothesis. Medical Hypotheses. 2025;194:111523.
5. Rashidian P, Karami S, Salehi SA. A review on retinopathy of prematurity. Medical Hypothesis, Discovery and Innovation in Ophthalmology. 2025;13(4):201. https://doi.org/ 10.51329/mehdiophthal1511. [DOI:10.51329/mehdiophthal1511.]
6. Habibi MRM, JafariMoghadam A, Norouzkhani N, Nazari E, Imani B, Kheirdoust A, et al. The use of neural networks to determine factors affecting the severity and extent of retinopathy in preterm infants. International Journal of Retina and Vitreous. 2025;11(1):30. https://doi.org/ 10.1186/s40942-025-00650-z. [DOI:10.1186/s40942-025-00650-z.]
7. Chiang MF, Quinn GE, Fielder AR, Ostmo SR, Chan RP, Berrocal A, et al. International classification of retinopathy of prematurity. Ophthalmology. 2021;128(10):e51-e68. https://doi.org/ 10.1016/j.ophtha.2021.05.031. [DOI:10.1016/j.ophtha.2021.05.031.]
8. Yonekawa Y, Thomas BJ, Thanos A, Todorich B, Drenser KA, Trese MT, et al. The cutting edge of retinopathy of prematurity care: expanding the boundaries of diagnosis and treatment. Retina. 2017;37(12):2208-25.
9. Camacho-Martinez E, Torres-Navarro K, Narvaez-Albarracin M, Kuzhda IM, Ramirez-Ortiz MA. Retinopathy of prematurity: Current status, treatment, prevention, and future directions from the perspective of developing countries. Kerala Journal of Ophthalmology. 2021;33(2):112-22. https://doi.org/ 10.1097/IAE.0000000000001719. [DOI:10.1097/IAE.0000000000001719.]
10. Motamed-Gorji N, Abri Aghdam K, Ashrafi E, Parvaresh M-M. Retinopathy of Prematurity in Iran. Archives of Persian Ophthalmology. 2020;1:33-65.
11. Zepeda-Romero LC, Barrera-de-Leon JC, Camacho-Choza C, Gonzalez Bernal C, Camarena-Garcia E, Diaz-Alatorre C, et al. Retinopathy of prematurity as a major cause of severe visual impairment and blindness in children in schools for the blind in Guadalajara city, Mexico. Br J Ophthalmol. 2011;95(11):1502-5. https://doi.org/ 10.1136/bjophthalmol-2011-300015. [DOI:10.1136/bjophthalmol-2011-300015.]
12. Rahi JS, Logan S, Timms C, Russell-Eggitt I, Taylor D. Risk, causes, and outcomes of visual impairment after loss of vision in the non-amblyopic eye: a population-based study. The Lancet. 2002;360(9333):597-602. https://doi.org/ 10.1016/s0140-6736(02)09782-9. [DOI:10.1016/s0140-6736(02)09782-9.]
13. Wylezinski LS, Gray JD, Polk JB, Harmata AJ, Spurlock III CF. Illuminating an invisible epidemic: a systemic review of the clinical and economic benefits of early diagnosis and treatment in inflammatory disease and related syndromes. Journal of clinical medicine. 2019;8(4):493. https://doi.org/ 10.3390/jcm8040493. [DOI:10.3390/jcm8040493.]
14. Azami M, Jaafari Z, Rahmati S, Farahani AD, Badfar G. Prevalence and risk factors of retinopathy of prematurity in Iran: a systematic review and meta-analysis. BMC ophthalmology. 2018;18:1-14. https://doi.org/ 10.1186/s12886-018-0732-3. [DOI:10.1186/s12886-018-0732-3.]
15. Bas AY, Demirel N, Koc E, Isik DU, Hirfanoglu İM, Tunc T. Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units. British journal of ophthalmology. 2018;102(12):1711-6. https://doi.org/ 10.1136/bjophthalmol-2017-311789. [DOI:10.1136/bjophthalmol-2017-311789.]
16. Waheeb S, Alshehri K. Incidence of retinopathy of prematurity at two tertiary centers in Jeddah, Saudi Arabia. Saudi Journal of Ophthalmology. 2016;30(2):109-12. https://doi.org/ 10.1016/j.sjopt.2016.02.006. [DOI:10.1016/j.sjopt.2016.02.006.]
17. Gerull R, Brauer V, Bassler D, Laubscher B, Pfister RE, Nelle M, et al. Incidence of retinopathy of prematurity (ROP) and ROP treatment in Switzerland 2006–2015: a population-based analysis. Archives of Disease in Childhood-Fetal and Neonatal Edition. 2018;103(4):F337-F42. https://doi.org/ 10.1136/archdischild-2017-313574. [DOI:10.1136/archdischild-2017-313574.]
18. Ludwig CA, Chen TA, Hernandez-Boussard T, Moshfeghi AA, Moshfeghi DM. The epidemiology of retinopathy of prematurity in the United States. Ophthalmic surgery, lasers & imaging retina. 2017;48(7):553. https://doi.org/ 10.3928/23258160-20170630-06. [DOI:10.3928/23258160-20170630-06.]
19. Asferaw M, Woodruff G, Gilbert C. Causes of severe visual impairment and blindness in students in schools for the blind in Northwest Ethiopia. BMJ global health. 2017;2(2):e000264. https://doi.org/ 10.1136/bmjgh-2016-000264. [DOI:10.1136/bmjgh-2016-000264.]
20. Gudlavalleti VSM. Magnitude and temporal trends in avoidable blindness in children (ABC) in India. The Indian Journal of Pediatrics. 2017;84:924-9. https://doi.org/ 10.1007/s12098-017-2405-2. [DOI:10.1007/s12098-017-2405-2.]
21. Hwang JH, Lee EH, Kim EA-R. Retinopathy of prematurity among very-low-birth-weight infants in Korea: incidence, treatment, and risk factors. Journal of Korean medical science. 2015;30(Suppl 1):S88. https://doi.org/ 10.3346/jkms.2015.30.S1.S88. [DOI:10.3346/jkms.2015.30.S1.S88.]
22. Solebo AL, Teoh L, Rahi J. Epidemiology of blindness in children. Archives of disease in childhood. 2017;102(9):853-7. https://doi.org/ 10.1136/archdischild-2016-310532. [DOI:10.1136/archdischild-2016-310532.]
23. Ozturk T, Er D, Yaman A, Berk AT. Changing trends over the last decade in the aetiology of childhood blindness: a study from a tertiary referral centre. British Journal of Ophthalmology. 2016;100(2):166-71. https://doi.org/ 10.1136/bjophthalmol-2015-306737. [DOI:10.1136/bjophthalmol-2015-306737.]
24. Peirovifar A, Gharehbaghi MM, Gharabaghi PM, Sadeghi K. Vascular endothelial growth factor and insulin-like growth factor-1 in preterm infants with retinopathy of prematurity. Singapore Med J. 2013;54(12):709-12. https://doi.org/ 10.11622/smedj.2013246. [DOI:10.11622/smedj.2013246.]
25. Khatami SF, YOUSEFI AE, FATEHI BGA, MAMOURI GA. Retinopathy of prematurity among 1000-2000 gram birth weight newborn infants. 2008.
26. Yaghoubi GH, Heydari B, Faal G, Heydari E, Alipour M. Prevalence and related factors of retinopathy of prematurity (ROP) in preterm infants in ophthalmology clinic of Birjand University of Medical Science from 2014 to 2016. Journal of Surgery and Trauma. 2017;5(3):62-6.

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.