Journal of Basic Research in Medical Sciences
J Basic Res Med Sci
Volume 13, Issue 3 (6-2026)
jbrms 2026, 13(3): 10-18 |
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pourrahim A, Kheiry M. The Role of Stem Cells in Cardiac Tissue Repair After Myocardial Infarction: Physiological Mechanisms. jbrms 2026; 13 (3) :10-18
URL: http://jbrms.medilam.ac.ir/article-1-1067-en.html
URL: http://jbrms.medilam.ac.ir/article-1-1067-en.html
Non-Communicable Diseases Research Center, Ilam University of Medical sciences, Ilam, Iran , m.kheiry@yahoo.com
Abstract: (1432 Views)
Introduction: Myocardial infarction induces IRI, leading to cardiomyocyte necrosis, neutrophil-driven inflammation, and fibroblast-mediated fibrosis, culminating in ventricular dysfunction. Stem Cell such as MSCs promote angiogenesis via VEGF/HGF paracrine secretion; CPCs differentiate through Notch/Wnt for tissue replacement; iPSCs enable patient-specific remuscularization with Cx43 integration.
Aim: The purpose of this study is to investigate the role of stem cells in cardiac tissue repair after myocardial infarction via physiological mechanisms.
Discussion: Stem cell–based therapies represent a promising yet evolving approach for cardiac repair following myocardial infarction. Preclinical models consistently demonstrate improvements in angiogenesis, attenuation of fibrosis, and partial restoration of ventricular function; however, these outcomes have not been fully replicated in clinical trials.
Conclusion: This review synthesizes mechanisms for advancing clinical translation. the future of cardiac regenerative medicine lies in the integration of mechanistic insights with bioengineering and molecular innovation.
Aim: The purpose of this study is to investigate the role of stem cells in cardiac tissue repair after myocardial infarction via physiological mechanisms.
Discussion: Stem cell–based therapies represent a promising yet evolving approach for cardiac repair following myocardial infarction. Preclinical models consistently demonstrate improvements in angiogenesis, attenuation of fibrosis, and partial restoration of ventricular function; however, these outcomes have not been fully replicated in clinical trials.
Conclusion: This review synthesizes mechanisms for advancing clinical translation. the future of cardiac regenerative medicine lies in the integration of mechanistic insights with bioengineering and molecular innovation.
Type of Study: Narrative review |
Subject:
Physiology
Received: 2025/12/24 | Accepted: 2026/04/6 | Published: 2026/06/16
Received: 2025/12/24 | Accepted: 2026/04/6 | Published: 2026/06/16
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