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:: Volume 7, Issue 2 (3-2020) ::
2020, 7(2): 38-46 Back to browse issues page
The effect of aerobic exercise and a synthesized insulin nanocomposite hydrogel on TNF-α and IL-6 in plasma of type 1 diabetic rats
Seyed nabiyollah Hoseini , Asieh Abbassi Daloii , Seyed Javad Ziaolhagh , Ayoub Saeidi
Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran , abbasi.daloii@gmail.com
Abstract:   (1951 Views)
Introduction: Diabetes is one of the leading causes of mortality in the world. The present study aimed to investigate the effect of aerobic exercise training and a synthesized insulin nanocomposite hydrogel on TNF-α and IL-6 in type 1 diabetic rats.
Materials and methods: Twenty-five rats were divided into five equal groups of animals each containing five animals, control - healthy, Control-diabetes, Nano-insulin Diabetes, Exercise Diabetes and Nano-insulin Diabetes-Exercise. The exercise training program lasted eight weeks. After the five days of familiarization, exercise time for the exercise groups were as follows: 20 m/min for the first and second weeks, 25 m/min for the third and fourth weeks and 30 m / min for the fifth and sixth weeks. The rats were also given the Nano-insulin supplement. Rats were killed 48 hours after the last training session. Their plasma was taken and used for the analysis of markers.
Results: There were significant differences in IL-6 (P<0.001) and TNF-α (P<0.001) between the groups.
Conclusion: The results of this study showed that aerobic exercise training along with Nano-insulin supplementation significantly reduced TNF-α and IL-6 in rats with type 1 diabetes and these changes were more in the Nano-insulin Diabetes group.
Keywords: Aerobic training, Synthesized insulin nanocomposite hydrogel, TNF-α, IL-6, Type 1 diabetic rat
Full-Text [PDF 399 kb]   (877 Downloads)    
Type of Study: Research | Subject: Public health
Received: 2019/08/1 | Accepted: 2019/09/21 | Published: 2020/03/1
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Hoseini S N, Abbassi Daloii A, Ziaolhagh S J, Saeidi A. The effect of aerobic exercise and a synthesized insulin nanocomposite hydrogel on TNF-α and IL-6 in plasma of type 1 diabetic rats. Journal of Basic Research in Medical Sciences 2020; 7 (2) :38-46
URL: http://jbrms.medilam.ac.ir/article-1-437-en.html

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Volume 7, Issue 2 (3-2020) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
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