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:: Volume 8, Issue 4 (9-2021) ::
2021, 8(4): 50-59 Back to browse issues page
The effect of high-intensity interval training (HIIT) on nesfatin, irisin and resistin and gene expression of PGC-1α in Wistar rats
Mozhgan Ahmadi
Department of Physical Education and Sport Science Yadegar-e-Imam Khomeini (RAH) Shahre-rey Branch, Islamic Azad University, Tehran, Iran , mahmadi1376@gmail.com
Abstract:   (1363 Views)
Introduction: The aim of this study was to evaluate the effect of high-intensity interval training (HIIT) on nesfatin, irisin and resistin and expression of peroxisome proliferator-activated receptor 1-alpha (PGC-1α) gene in Wistar rats.
Materials and Methods: In this experimental study, 24 male Wistar rats (weight 300-250 g) were selected and randomly assigned into three groups: baseline control, eight-week control and HIIT training. The experimental group performed training protocol 4 days a week during 8 weeks, while the control group had no training program. To measure the levels of serum irisin, nesfatin, and resistin, the immunoassay method was used. Additionally, the real-time PCR method was applied to evaluate the relative PGC-1α mRNA level in soleus muscle. Independent T-test was used to analyze the data.
Results: The results suggested that there was no significant difference between the concentration of nesfatin, irisin and resistin in the baseline control group compared to the eight-week control group (P > 0.05). HIIT increased the concentrations of nesfatin-1 and irisin (P = 0.0001), and significantly decreased resistin (P = 0.0001). Furthermore, eight weeks of HIIT significantly increased the PGC-1α mRNA (P = 0.0001).
Conclusion: According to the findings of the study, HIIT would possibly help to improve the levels of the factors, nesfatin, irisin, resistin and PGC-1α which involved in the energy balance homoeostasis.
Keywords: High-intensity interval training, Nesfatin, Irisin, Resistin, PGC-1α, Rats
Full-Text [PDF 349 kb]   (486 Downloads)    
Type of Study: Research | Subject: Physical medicine
Received: 2019/11/7 | Accepted: 2020/05/13 | Published: 2021/09/19
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Ahmadi M. The effect of high-intensity interval training (HIIT) on nesfatin, irisin and resistin and gene expression of PGC-1α in Wistar rats. Journal of Basic Research in Medical Sciences 2021; 8 (4) :50-59
URL: http://jbrms.medilam.ac.ir/article-1-446-en.html

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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 8, Issue 4 (9-2021) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
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