[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
About Journal::
Editorial Board::
Articles Archive::
Indexing Databases::
To Authors::
To Reviewers::
Registration::
Submit Your Article::
Policies and Publication Ethics::
Archiving Policy::
Site Facilities::
Contact Us::
::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019
Citations745605
h-index1110
i10-index1513
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Registered in

AWT IMAGE

AWT IMAGE

..
:: Volume 10, Issue 1 (1-2023) ::
2023, 10(1): 31-37 Back to browse issues page
Inhibition of oral cancer cell line KB by hydroxytyrosol through induction of apoptosis
Zahra Amini , Rasoul Etemadi , Gholamreza Jahangirzadeh Sooreh , Milad Jaberi
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran , milad.jaberi@gmail.com
Abstract:   (527 Views)
Introduction: Cancer is a disorder with a high mortality rate that leads to many psychological and economic conflicts. Herbal compounds that induce apoptosis are one of the methods for the treatment of cancer. The aim of the present study was to evaluate the anticancer effects of hydroxytyrosol on oral cancer cell line KB and the regulation of BAX and BCL2 genes expression.
Materials and Methods: Anti-proliferation effects of hydroxytyrosol against oral cancer cell line KB were investigated by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay. Moreover, mRNA expression of BAX and BCL2 genes were investigated by quantitative Real-Time PCR method.
Results: We observed a significant decrease in proliferation of the oral cancer cell line treated with hydroxytyrosol. In addition, expression of BAX and BCL2 genes was significantly increased (3.3 fold) and decreased (2.2 fold) in the oral cancer cell line treated with Hydroxytyrosol, respectively (P < 0.05).
Conclusion: The study indicated a high antiproliferation effect of hydroxytyrosol against oral cancer cell line KB through regulating the expression of some apoptotic genes.
 
Keywords: Oral cancer, Hydroxytyrosol, Apoptosis, Anticancer
Full-Text [PDF 384 kb]   (160 Downloads)    
Type of Study: Research | Subject: Toxicology
Received: 2021/01/27 | Accepted: 2021/03/1 | Published: 2023/01/10
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Amini Z, Etemadi R, Jahangirzadeh Sooreh G, Jaberi M. Inhibition of oral cancer cell line KB by hydroxytyrosol through induction of apoptosis. Journal of Basic Research in Medical Sciences 2023; 10 (1) :31-37
URL: http://jbrms.medilam.ac.ir/article-1-587-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 10, Issue 1 (1-2023) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
Persian site map - English site map - Created in 0.16 seconds with 41 queries by YEKTAWEB 4654