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:: Volume 10, Issue 3 (6-2023) ::
2023, 10(3): 1-11 Back to browse issues page
The Impact of Varying Circuit Resistance Training Intensity on Apolipoproteins in Men with Obesity
Mahdi Rezaei Mahbobi , Akbar Nouri-Habashi
Department of Exercise Physiology and Corrective Movements, Faculty of Sport Sciences, Urmia University, Urmia, Iran , akbarnori52@gmail.com
Abstract:   (322 Views)
Introduction: This study aimed to investigate the impact of 12 weeks of circuit resistance training at varying intensities on Apolipoproteins A (Apo A), B (Apo B), and J (Apo J) in men with obesity.

Material & Methods: A total of 44 young men with obesity, aged 23-32 years, were divided into four groups: control (n=11), low-intensity (n=11), moderate-intensity (n=11), and high-intensity circuit resistance training (n=11) groups. The training program spanned 12 weeks and was conducted with three sessions per week. Blood samples were collected 72 hours before and 72 hours after the 12-week training programs. These blood samples were transferred to specialized plasma test tubes containing EDTA and were then centrifuged at 10 rpm for 10 minutes.

Findings: A significant decrease in Apo B levels (P < 0.0001) and an increase in Apo A levels (P < 0.05) were observed in the low-intensity training group compared to the control group. Additionally, a significant decrease in Apo J levels was observed in all exercise training groups compared to the control group (P < 0.05).
Discussion & Conclusion: The findings of this study suggest that circuit resistance training, particularly at lower intensities, may lead to a reduction in the risk of cardiovascular diseases in obese individuals through the modification of Apo A, Apo B, and Apo J levels.
Keywords: Circuit Resistance Training, Obese Men, Apolipoprotein, Training Intensity
Full-Text [PDF 2437 kb]   (67 Downloads)    
Type of Study: Research | Subject: Health education
Received: 2022/02/10 | Accepted: 2022/02/11 | Published: 2023/06/25
1. Marinou K, Tousoulis D, Antonopoulos AS, Stefanadi E, Stefanadis C. Obesity and cardiovascular disease: from pathophysiology to risk stratification. Int J cardiol. 2010; 138(1):3-8. doi: 10.1016/j.ijcard.2009.03.135.
2. Bijeh N, Sarlak Z, Farahati S. Effects of eight weeks aerobic training on serum Apo A-1, B and lipid profile in overweight women. Sport Physiology. 2016; 7(28): 45-58.
3. Talebi-Garakani E. The Effect of Resistance Training Intensity on Serum ApoA-I Concentration in Streptozotocin-Induced Diabetic Rats. Iran J Endocrinol Metab. 2013;15(2):183-9.
4. Faam B, Hedayati M, Azizi F. Presence of the X+ allele in apolipoprotein b gene increase the total cholesterol and apolipoprotein b concentration in tehranian people. Iran J Endocrinol Metab. 2011;12(6):588-93.
5. Ng TW, Watts GF, Farvid MS, Chan DC, Barrett PHR. Adipocytokines and VLDL metabolism: independent regulatory effects of adiponectin, insulin resistance, and fat compartments on VLDL apolipoprotein B-100 kinetics? Diabetes. 2005;54(3):795-802. doi: 10.2337/diabetes.54.3.795.
6. Ghorbanian B, Ravassi A, Kordi MR, Hedayati M. The effects of rope training on lymphocyte ABCA1 expression, plasma ApoA-I and HDL-c in boy adolescents. Int J Endocrinol Metab. 2013;11(2):76. doi: 10.5812/ijem.8178.
7. Mashaykhi NR, Sadrneya S, Chehrei A, Javaheri J, Ahmadlou M. The correlation between serum apo lipoprotein A1 and apo lipoprotein B with coronary artery disease and its severity. J Arak Uni Med Sci. 2013;16(6):82-9.
8. Kadoglou NP, Fotiadis G, Athanasiadou Z, Vitta I, Lampropoulos S, Vrabas IS. The effects of resistance training on ApoB/ApoA-I ratio, Lp (a) and inflammatory markers in patients with type 2 diabetes. Endocrine. 2012;42(3):561-9. doi: 10.1007/s12020-012-9650-y.
9. Rashidlamir A, Ghanbari-Niaki A, Saadatnia A. The Effect of eight weeks of wrestling and wrestling technique-based circuit training on lymphocyte ABCA1 gene expression and plasma apolipoprotein AI. World J Sport Sci. 2011;2(2):144-50.
10. Malekpour-Dehkordi Z, Javadi E, Doosti M, Paknejad M, Nourbakhsh M, Yassa N, et al. The effect of Alcoholic garlic (Allium sativum) extract on ABCA1 expression in human THP-1 macrophages. Tehran Univ Med J. 2011;69(3) :146-152.
11. Trougakos IP, Gonos ES. Clusterin/apolipoprotein J in human aging and cancer. Int J Biochem Cell Biol. 2002;34(11):1430-48. doi: 10.1016/s1357-2725(02)00041-9.
12. Bi J, Guo A, Lai Y, Li B, Zhong J, Wu H, et al. Overexpression of clusterin correlates with tumor progression, metastasis in gastric cancer: a study on tissue microarrays. Neoplasma. 2010;57(3):191. doi: 10.4149/neo_2010_03_191.
13. Won JC, Park CY, Oh SW, Lee ES, Youn BS, Kim MS. Plasma clusterin (ApoJ) levels are associated with adiposity and systemic inflammation. PLoS One. 2014;9(7): e103351. doi: 10.1371/journal.pone.0103351.
14. Seo JA, Kang M-C, Ciaraldi TP, Kim SS, Park KS, Choe C, et al. Circulating ApoJ is closely associated with insulin resistance in human subjects. Metabolism. 2018; 78:155-66. doi: 10.1016/j.metabol.2017.09.014.
15. Jeon YK, Kim SS, Kim JH, Kim HJ, Kim HJ, Park JJ, et al. Combined aerobic and resistance exercise training reduces circulating apolipoprotein J levels and improves insulin resistance in postmenopausal diabetic women. Diabetes Metab J. 2020;44(1):103-12. doi: 10.4093/dmj.2018.0160.
16. Navab M, Anantharamaiah G, Reddy ST, Van Lenten BJ, Wagner AC, Hama S, et al. An Oral ApoJ Peptide Renders HDL Anti-inflammatory in Mice and Monkeys and Dramatically Reduces Atherosclerosis in Apolipoprotein E–Null Mice. Arterioscler Thromb Vasc Biol. 2005;25(9):1932-7. doi: 10.1161/01.ATV.0000174589. 70190.e2.
17. Yang N, Qin Q. Apolipoprotein J: a new predictor and therapeutic target in cardiovascular disease? Chin Med J. 2015;128(18):2530-4. doi: 10.4103/0366-6999.164983.
18. Zanuso S, Jimenez A, Pugliese G, Corigliano G, Balducci S. Exercise for the management of type 2 diabetes: a review of the evidence. Acta Diabetol. 2010;47(1):15-22. doi: 10.1007/s00592-009-0126-3.
19. Oliveira C, Simões M, Carvalho J, Ribeiro J. Combined exercise for people with type 2 diabetes mellitus: a systematic review. Diabetes Res Clin Pract. 2012;98(2):187-98. doi: 10.1016/j.diabres.2012.08.004.
20. Colberg SR, Sigal RJ, Fernhall B, Regensteiner JG, Blissmer BJ, Rubin RR, et al. Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement. Med Sci Sports Exerc. 2010;42(12):2282-303. doi: 10.1249/MSS.0b013e3181eeb61c.
21. Rull A, Martínez-Bujidos M, Pérez-Cuellar M, Pérez A, Ordóñez-Llanos J, Sánchez-Quesada JL. Increased concentration of clusterin/apolipoprotein J (apoJ) in hyperlipemic serum is paradoxically associated with decreased apoJ content in lipoproteins. Atherosclerosis. 2015;241(2):463-70. doi: 10.1016/j.atherosclerosis.2015.06.003.
22. Brzycki M. Strength testing—predicting a one-rep max from reps-to-fatigue. J Phys Educ Recreat Dance. 1993;64(1):88-90. doi.org/10.1080/07303084.1993.10606684.
23. Zanuso S, Bergamin M, Jimenez A, Pugliese G, D'Errico V, Nicolucci A, et al. Determination of metabolic equivalents during low-and high-intensity resistance exercise in healthy young subjects and patients with type 2 diabetes. Biol Sport. 2016;33(1):77. doi: 10.5604/20831862.1194124.
24. Romero-Arenas S, Martínez-Pascual M, Alcaraz PE. Impact of resistance circuit training on neuromuscular, cardiorespiratory and body composition adaptations in the elderly. Aging Dis. 2013;4(5):256. doi: 10.14336/AD.2013.0400256.
25. Baechle TR, Earle RW. Essentials of strength training and conditioning: Human Kinetics. 2008.
26. Mukaimoto T, Ohno M. Effects of circuit low-intensity resistance exercise with slow movement on oxygen consumption during and after exercise. J Sports Sci. 2012;30(1):79-90. doi: 10.1080/02640414.2011.616950.
27. Sarlak Z. Effects of Eight Weeks Aerobic Training on Serum Apo AI, APO B and lipid profile in Overweight Women. Sport Physiology. 2016 ;7(28):45-58. doi: 20.1001.1.2322164.1394.
28. Trougakos IP, Poulakou M, Stathatos M, Chalikia A, Melidonis A, Gonos ES. Serum levels of the senescence biomarker clusterin/apolipoprotein J increase significantly in diabetes type II and during development of coronary heart disease or at myocardial infarction. Exp Gerontol. 2002;37(10-11):1175-87. doi: 10.1016/s0531-5565(02)00139-0.
29. Aronis KN, Vamvini MT, Chamberland JP, Mantzoros CS. Circulating clusterin (apolipoprotein J) levels do not have any day/night variability and are positively associated with total and LDL cholesterol levels in young healthy individuals. J Clin Endocrinol Metab. 2011;96(11): doi: 10.1210/jc.2011-1555.
30. Sheikholeslami Vatani D, Ahmadi S, Ahmadi Dehrashid K, Gharibi F. Changes in cardiovascular risk factors and inflammatory markers of young, healthy, men after six weeks of moderate or high intensity resistance training. J Sports Med Phys Fitness. 2011;51(4):695-700.
31. Valente EA, Sheehy ME, Avila JJ, Gutierres JA, Delmonico MJ, Lofgren IE. The effect of the addition of resistance training to a dietary education intervention on apolipoproteins and diet quality in overweight and obese older adults. Clin Interv Aging. 2011; 6:235. doi: 10.2147/CIA.S23583.
32. Thompson PD, Buchner D, Piña IL, Balady GJ, Williams MA, Marcus BH, et al. Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity). Circulation. 2003;107(24):3109-16. doi: 10.1161/01.CIR.0000075572.40158.77.
33. Behre C, Bergström G, Schmidt C. Moderate physical activity is associated with lower ApoB/ApoA-I ratios independently of other risk factors in healthy, middle-aged men. Angiology. 2010;61(8):775-9. doi: 10.1177/0003319710373746.
34. De Groot P, Hjeltnes N, Heijboer A, Stal W, Birkeland K. Effect of training intensity on physical capacity, lipid profile and insulin sensitivity in early rehabilitation of spinal cord injured individuals. Spinal Cord. 2003;41(12):673-9. doi: 10.1038/sj.sc.3101534.
35. Kannan U, Vasudevan K, Balasubramaniam K, Yerrabelli D, Shanmugavel K, John NA. Effect of exercise intensity on lipid profile in sedentary obese adults. Journal of clinical and diagnostic research: JCDR. 2014;8(7): BC08. doi: 10.7860/JCDR/2014/8519.4611.
36. Baharloo S, Shakeri N, Ebrahim K, Ramezani Tehrani F, Allameh Z. The effect of 12 weeks water-based Tabata training on insulin resistance, apolipoprotein A and apolipoprotein B in obese women with polycystic ovary syndrome. RJMS. 2021;28(5):11-20.
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Rezaei Mahbobi M, Nouri-Habashi A. The Impact of Varying Circuit Resistance Training Intensity on Apolipoproteins in Men with Obesity. Journal of Basic Research in Medical Sciences 2023; 10 (3) :1-11
URL: http://jbrms.medilam.ac.ir/article-1-664-en.html

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Volume 10, Issue 3 (6-2023) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
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